Mixed Metal Metal-Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging

doi:10.1021/acs.nanolett.0c04455

	Mixed Metal Metal-Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging
	Jiang, Zhenqi 1,2; Han, Xiao 2,3; Du, Yang3,4 ; Li, Yanying 1,4,5; Li, Yong 1; Li, Juan 1,5; Tian, Jie 3,6; Wu, Aiguo 1,5
发表期刊	NANO LETTERS
ISSN	1530-6984
	2021-04-14
卷号	21 期号:7 页码:2730-2737
通讯作者	Li, Juan(lij@nimte.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Wu, Aiguo(aiguo@nimte.ac.cn)
摘要	Recently, magnetic particle imaging (MPI) has shown diverse biomedical applications such as cell tracking, lung perfusion, image-guided hyperthermia, and so forth. However, the currently reported MPI agents cannot achieve the possible theoretical detection limit of MPI (20 nM). A previous theoretical study has shown that the MPI performance of superparamagnetic iron oxide nanoparticles (SPIONs) can be enhanced by carbon supporting and metal doping. In the current study, a series of mixed metal metal-organic framework-derived carbon supporting SPIONs were synthesized by pyrolysis. Among the synthesized SPIONs, the MPI signal intensity of ZnFe2O4/C@PDA was found to be 4.7 times higher than the commercial MPI contrast (Vivotrax) having the same Fe concentration. ZnFe2O4/C@PDA also showed the highest MPI intensity in tumor-bearing-mice among all tested samples. Furthermore, they were found highly biocompatible and showed linear cell quantification. This work can open new avenues for the design and development of novel and high-performance MPI agents.
关键词	Magnetic Particle Imaging Metal-Organic Frameworks High-Temperature Pyrolysis Esophageal Squamous Cell Cancer
DOI	10.1021/acs.nanolett.0c04455
关键词[WOS]	FAVORABLE BIOCOMPATIBILITY ; NANOPARTICLES ; ACCUMULATION
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81871411] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81871514] ; National Natural Science Foundation of China[32011530115] ; National Natural Science Foundation of China[32025021] ; Key R&D Program of Zhejiang Province[2020C03110] ; Youth Innovation Promotion Association Foundation of CAS[2017340] ; National Key R&D Program of China[2018YFC0910601] ; Beijing Natural Science Foundation[7212207] ; China Postdoctoral Science Foundation[2020M680395]
项目资助者	National Natural Science Foundation of China ; Key R&D Program of Zhejiang Province ; Youth Innovation Promotion Association Foundation of CAS ; National Key R&D Program of China ; Beijing Natural Science Foundation ; China Postdoctoral Science Foundation
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000641160500004
出版者	AMER CHEMICAL SOC
七大方向——子方向分类	其他
引用统计	被引频次：31[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/44483
专题	中国科学院分子影像重点实验室
通讯作者	Li, Juan; Tian, Jie; Wu, Aiguo
作者单位	1.Chinese Acad Sci, Zhejiang Engn Res Ctr Biomed Mat, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn,CAS Key Lab Magnet, Ningbo 315201, Peoples R China 2.Beijing Inst Technol, Inst Engn Med, Sch Life Sci, Beijing 100081, Peoples R China 3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Adv Energy Sci & Technol Guangdong Lab, Huizhou 516003, Peoples R China 6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Jiang, Zhenqi,Han, Xiao,Du, Yang,et al. Mixed Metal Metal-Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging[J]. NANO LETTERS,2021,21(7):2730-2737.
APA	Jiang, Zhenqi.,Han, Xiao.,Du, Yang.,Li, Yanying.,Li, Yong.,...&Wu, Aiguo.(2021).Mixed Metal Metal-Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging.NANO LETTERS,21(7),2730-2737.
MLA	Jiang, Zhenqi,et al."Mixed Metal Metal-Organic Frameworks Derived Carbon Supporting ZnFe2O4/C for High-Performance Magnetic Particle Imaging".NANO LETTERS 21.7(2021):2730-2737.