| Persistent moderate to severe pain and long-term cognitive decline | |
Rong, Wei1; Zhang, Cheng2 ; Zheng, Fanfan3; Xiao, Songhua1; Yang, Zhenchun4; Xie, Wuxiang5,6
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| 发表期刊 | EUROPEAN JOURNAL OF PAIN
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| ISSN | 1090-3801 |
| 2021-07-05 | |
| 页码 | 10 |
| 通讯作者 | Xie, Wuxiang(xiewuxiang@hsc.pku.edu.cn) |
| 摘要 | Background The longitudinal association between persistent moderate to severe pain and subsequent long-term cognitive decline remains inconclusive. Methods Study population came from the English Longitudinal Study of Ageing, an ongoing prospective and nationally representative cohort of community-dwelling adults aged >= 50 years in England. At waves 1 (2002/2003) and 2 (2004/2005) of the study, pain severity was measured based on pain intensity scores ranged from 0 to 10. We defined moderate to severe pain as pain intensity scores >= 5 points. Persistent moderate to severe pain was defined as participants reported moderate to severe pain at both waves 1 and 2. Standardized global cognitive Z scores derived from verbal memory, temporal orientation and semantic fluency were used as the primary outcome. Results A total of 6,869 individuals (3,896 women; mean age: 63.9 +/- 9.5 years) who have accepted twice measurements of pain at waves 1 and 2 (baseline), and at least one reassessment of cognitive function at waves 3 (2006/2007) to 8 (2016/2017), were included in this study. Each 5-point increase in the sum of pain intensity scores was associated with a faster rate of -0.009 (95% CI: -0.013 to -0.006, p < .001) in global cognitive Z scores. Compared with no pain group, persistent moderate to severe pain group was associated with a significantly faster decline rate of -0.031 SD/year (95% CI: -0.043 to -0.018), in global cognitive Z scores. The relationships of persistent moderate to severe pain with verbal memory, temporal orientation and semantic fluency were similar. Conclusion Cognitive function should be monitored in individuals with persistent moderate to severe pain. Significance Persistent moderate to severe pain in adults age 50 and older was associated with accelerated cognitive decline over a median follow-up of 12 years. More severe pain was associated with faster cognitive decline in a dose-response pattern, and the relationship was demonstrated throughout multiple cognitive domains. While the overall effect was subtle, clinicians should be aware that older adults with persistent pain are at risk of faster cognitive decline. |
| DOI | 10.1002/ejp.1826 |
| 关键词[WOS] | OPIOIDS ; PREVALENCE ; DEMENTIA |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[81974490] ; Beijing Natural Science Foundation[7182108] ; Newton International Fellowship from the Academy of Medical Sciences, UK[NIF001-1005-P56804] ; 2019 Irma and Paul Milstein Program for Senior Health Research Project Award |
| 项目资助者 | National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Newton International Fellowship from the Academy of Medical Sciences, UK ; 2019 Irma and Paul Milstein Program for Senior Health Research Project Award |
| WOS研究方向 | Anesthesiology ; Neurosciences & Neurology |
| WOS类目 | Anesthesiology ; Clinical Neurology ; Neurosciences |
| WOS记录号 | WOS:000669746400001 |
| 出版者 | WILEY |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/45244 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 通讯作者 | Xie, Wuxiang |
| 作者单位 | 1.Tsinghua Univ, Beijing Tsinghua Changgung Hosp, Dept Orthoped, Med Ctr, Beijing, Peoples R China 2.Chinese Acad Sci, Beijing Key Lab Bioelectromagnetism, Inst Elect Engn, Beijing, Peoples R China 3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 4.Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England 5.Peking Univ, Clin Res Inst, Hosp 1, 8 Xishiku St, Beijing 100034, Peoples R China 6.Peking Univ, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Rong, Wei,Zhang, Cheng,Zheng, Fanfan,et al. Persistent moderate to severe pain and long-term cognitive decline[J]. EUROPEAN JOURNAL OF PAIN,2021:10. |
| APA | Rong, Wei,Zhang, Cheng,Zheng, Fanfan,Xiao, Songhua,Yang, Zhenchun,&Xie, Wuxiang.(2021).Persistent moderate to severe pain and long-term cognitive decline.EUROPEAN JOURNAL OF PAIN,10. |
| MLA | Rong, Wei,et al."Persistent moderate to severe pain and long-term cognitive decline".EUROPEAN JOURNAL OF PAIN (2021):10. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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