Subtypes of depression characterized by different cognitive decline and brain activity alterations

doi:10.1016/j.jpsychires.2021.04.023

	Subtypes of depression characterized by different cognitive decline and brain activity alterations
	Yang, Xiao 1,2; Qi, Shile3 ; Wang, Min1,2 ; Calhoun, Vince D.3; Sui, Jing4,5,6,7 ; Li, Tao1,2 ; Ma, Xiaohong 1,2
发表期刊	JOURNAL OF PSYCHIATRIC RESEARCH
ISSN	0022-3956
	2021-06-01
卷号	138 页码:413-419
通讯作者	Ma, Xiaohong(maxiaohong@scu.edu.cn)
摘要	Depression is characterized by the heterogeneity in anti-depressant treatment response and clinical outcomes. Cognitive impairment may be one of the more practically important aspects of depression. A new approach was to identify neuropsychologically derived depression subtypes based on the trajectory of neuro-cognition such as intelligence quotient (IQ) change. We used a classical premorbid IQ prediction algorithm and then compared predicted premorbid IQ with current IQ. IQ change was used to delineate the patterns of neuropsychological heterogeneity within a large dataset consisting of 131 patients with major depressive disorder (MDD) and 165 healthy controls (HCs). Neurocognitive results from CANTAB and 3 T resting-state fMRI data were compared among the subgroups identified. IQ change heterogeneity identified two subgroups within the MDD group: preserved IQ (PIQ) and deteriorated IQ (DIQ) in MDD. The DIQ subgroup was marked by poorer functioning across multiple cognition domains, including increased impairments in motor speed, cognitive flexibility, and catastrophic thinking when compared to PIQ and HCs. Moreover, cognitive performance of patients with DIQ was correlated with IQ decline. Also, increased brain activity of anterior cingulate cortex and medial prefrontal cortex was found in DIQ but not in PIQ and HCs. IQ-based subgroups of depression may be differentially associated with the extent of neurocognitive impairment and brain activities, which suggests that classifying the cognitive heterogeneity associated with depression may provide a platform to better characterize the neurobiological underpinnings of the disease.
关键词	Major depressive disorder Premorbid intelligence quotient Subtypes Cognition Resting-state network
DOI	10.1016/j.jpsychires.2021.04.023
关键词[WOS]	UNIPOLAR DEPRESSION ; INCREASED AMYGDALA ; PREFRONTAL CORTEX ; PREMORBID IQ ; SCHIZOPHRENIA ; DISORDER ; FMRI ; HETEROGENEITY ; IMPAIRMENTS ; NETWORK
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[82001432] ; National Natural Science Foundation of China[81671344] ; China Postdoctoral Science Foundation[2020TQ0213] ; China Postdoctoral Science Foundation[2020M683319] ; Special Foundation for Brain Research from Science and Technology Program of Guangdong[2018B030334001] ; China Scholarship Council (CSC)[201706240074] ; Open Project Program of the National Laboratory of Pattern Recognition[202000034]
项目资助者	National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Special Foundation for Brain Research from Science and Technology Program of Guangdong ; China Scholarship Council (CSC) ; Open Project Program of the National Laboratory of Pattern Recognition
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000658540100015
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/45329
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Ma, Xiaohong
作者单位	1.Sichuan Univ, Psychiat Lab & Mental Hlth Ctr, State Key Lab Biotherapy, West China Hosp, Chengdu, Sichuan, Peoples R China 2.Sichuan Univ, West China Brain Res Ctr, West China Hosp, Chengdu, Sichuan, Peoples R China 3.Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA USA 4.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China 5.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yang, Xiao,Qi, Shile,Wang, Min,et al. Subtypes of depression characterized by different cognitive decline and brain activity alterations[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2021,138:413-419.
APA	Yang, Xiao.,Qi, Shile.,Wang, Min.,Calhoun, Vince D..,Sui, Jing.,...&Ma, Xiaohong.(2021).Subtypes of depression characterized by different cognitive decline and brain activity alterations.JOURNAL OF PSYCHIATRIC RESEARCH,138,413-419.
MLA	Yang, Xiao,et al."Subtypes of depression characterized by different cognitive decline and brain activity alterations".JOURNAL OF PSYCHIATRIC RESEARCH 138(2021):413-419.