Altered functional connectivity between the nucleus basalis of Meynert and anterior cingulate cortex is associated with declined attentional performance after total sleep deprivation

doi:10.1016/j.bbr.2021.113321

	Altered functional connectivity between the nucleus basalis of Meynert and anterior cingulate cortex is associated with declined attentional performance after total sleep deprivation
	Qi, Jing 1,2; Li, Bo-Zhi 2; Zhang, Ying 3; Pan, Bei 4; Gao, Yu-Hong 5; Zhan, Hao 4; Liu, Yong6,7,8,9 ; Shao, Yong-Cong 10,11; Zhang, Xi 1,2
发表期刊	BEHAVIOURAL BRAIN RESEARCH
ISSN	0166-4328
	2021-07-09
卷号	409 页码:7
通讯作者	Shao, Yong-Cong(beijingshuimian@163.com) ; Zhang, Xi(smrc301@163.com)
摘要	Background: Sleep deprivation can markedly influence vigilant attention. The nucleus basalis of Meynert (NBM), the main source of cholinergic projections to the cortex, plays an important role in wakefulness maintenance and attention control. However, the involvement of NBM in attentional impairments after total sleep deprivation (TSD) has yet to be established. The purpose of this study is to investigate the alterations in NBM functional connectivity and its association with the attentional performance following TSD. Methods: Thirty healthy adult males were recruited in the study. Participants underwent two resting-state functional magnetic resonance imaging (rs-fMRI) scans, once in rested wakefulness (RW) and once after 36 h of TSD. Seed-based functional connectivity analysis was performed using rs-fMRI data for the left and right NBM. The vigilant attention was measured using a psychomotor vigilance test (PVT). Furthermore, Pearson correlation analysis was conducted to investigate the relationship between altered NBM functional connectivity and changed PVT performance after TSD. Results: Compared to RW, enhanced functional connectivity was observed between right NBM and bilateral thalamus and cingulate cortex, while reduced functional connectivity was observed between left NBM and right superior parietal lobule following TSD. Moreover, altered NBM functional connectivity with the left anterior cingulate cortex was negatively correlated with PVT performance after TSD. Conclusion: Our results suggest that the disrupted NBM-related cholinergic circuit highlights an important role in attentional performance after TSD. The enhanced NBM functional connectivity with the anterior cingulate cortex may act as neural signatures for attentional deficits induced by sleep deprivation.
关键词	Sleep deprivation Vigilant attention Nucleus basalis of Meynert Functional connectivity fMRI
DOI	10.1016/j.bbr.2021.113321
关键词[WOS]	NICOTINIC RECEPTORS ; RAT ; VULNERABILITY ; SUBREGIONS ; NEURONS ; MAPS
收录类别	SCI
语种	英语
资助项目	Science Foundation[AWS16J023] ; Science Foundation[1716312ZT00211101]
项目资助者	Science Foundation
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
WOS类目	Behavioral Sciences ; Neurosciences
WOS记录号	WOS:000663072600009
出版者	ELSEVIER
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/45341
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Shao, Yong-Cong; Zhang, Xi
作者单位	1.Nankai Univ, Sch Med, Tianjin 300071, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Secondary Med Ctr, Sleep Med Res Ctr, Natl Clin Res Ctr Geriatr Dis,Dept Neurol, Beijing 100853, Peoples R China 3.Gen Hosp Peoples Liberat Army, Eighth Med Ctr, Beijing 100091, Peoples R China 4.PLA, Airforce Med Ctr, Beijing 100142, Peoples R China 5.Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Med Ctr 2, Beijing 100853, Peoples R China 6.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 7.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 8.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Automat, Beijing 100190, Peoples R China 9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 10.Beijing Sport Univ, Sch Psychol, Beijing 100084, Peoples R China 11.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Qi, Jing,Li, Bo-Zhi,Zhang, Ying,et al. Altered functional connectivity between the nucleus basalis of Meynert and anterior cingulate cortex is associated with declined attentional performance after total sleep deprivation[J]. BEHAVIOURAL BRAIN RESEARCH,2021,409:7.
APA	Qi, Jing.,Li, Bo-Zhi.,Zhang, Ying.,Pan, Bei.,Gao, Yu-Hong.,...&Zhang, Xi.(2021).Altered functional connectivity between the nucleus basalis of Meynert and anterior cingulate cortex is associated with declined attentional performance after total sleep deprivation.BEHAVIOURAL BRAIN RESEARCH,409,7.
MLA	Qi, Jing,et al."Altered functional connectivity between the nucleus basalis of Meynert and anterior cingulate cortex is associated with declined attentional performance after total sleep deprivation".BEHAVIOURAL BRAIN RESEARCH 409(2021):7.