Activable Nanoparticle for Tumor Aggressiveness and Drug Resistance Prediction by Glutathione Heterogeneous Imaging

doi:10.1166/jbn.2021.3124

	Activable Nanoparticle for Tumor Aggressiveness and Drug Resistance Prediction by Glutathione Heterogeneous Imaging
	Wang, Yaqin 1; Shang, Wenting2 ; Xiong, Jianping 3; Liu, Yu2 ; Luo, Ting 1; Qi, Xun 1,4; Niu, Meng 1; Xu, Ke 1
发表期刊	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
ISSN	1550-7033
	2021-07-01
卷号	17 期号:7 页码:1339-1348
通讯作者	Qi, Xun(qixun716@hotmail.com) ; Niu, Meng(guanjh@cmu.edu.cn) ; Xu, Ke(kxu@cmu.edu.cn)
摘要	Studies have shown that a higher GSH level is related to more drug-resistant and invasiveness of a tumor. However, it is a great challenge to accurately imaging the GSH level in vivo, for its imaging intensity will interfered by different accumulation of probes in the tumor. Thus, we hypothesized ratiometric photoacoustic imaging that can be used to predict the drug-resistant and invasiveness of tumors by accurate GSH level imaging. In this study, we synthesized MnO2/Indocyanine Green (MnO2/ICG). It can be used as ratiometric photoacoustic (PA) imaging probe, for its absorption at 780 nm (Ab(780)) can be decreased and 680 nm (Ab(680)) remain unchanged upon GSH reduction. And our results confirmed that a lower PA absorption ratio (Ab(780)/Ab(680)) corresponded to a higher GSH level of the tumor. Besides, the near-infrared fluorescence (FI) imaging was used as an assistant, for it can be quenched upon GSH. Therefore, MnO2/ICG can predict the tumor invasiveness and drug resistance by imaging the GSH level. This study provides reference to predict the prognosis of tumors by imaging the metabolic biomarker of tumors.
关键词	GSH imaging Tumor Invasiveness Resistance Heterogenetic Nanoparticle Ratiometric Photoacoustic Imaging
DOI	10.1166/jbn.2021.3124
关键词[WOS]	CANCER ; AMPLIFICATION ; THERAPY ; CELLS
收录类别	SCI
语种	英语
资助项目	National Key Research and Development Program of China[2019YFC0118100] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81630053] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81601584] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501540] ; Ministry of Science and Technology of China[2017YFA0700401] ; Chinese Academy of Sciences[YJKYYQ20170075] ; Chinese Academy of Sciences[XDBS01030200]
项目资助者	National Key Research and Development Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China ; Chinese Academy of Sciences
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS记录号	WOS:000691557400002
出版者	AMER SCIENTIFIC PUBLISHERS
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/45909
专题	中国科学院分子影像重点实验室
通讯作者	Qi, Xun; Niu, Meng; Xu, Ke
作者单位	1.China Med Univ, Dept Intervent Radiol, Affiliated Hosp 1, Shenyang 110000, Liaoning, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Chinese Acad Med Sci & Peking Union Med Coll, Dept Pancreat & Gastr Surg, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100000, Peoples R China 4.China Med Univ, Dept Radiol, Key Lab Diagnost Imaging & Intervent Radiol Liaon, Affiliated Hosp 1, Shenyang 110000, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yaqin,Shang, Wenting,Xiong, Jianping,et al. Activable Nanoparticle for Tumor Aggressiveness and Drug Resistance Prediction by Glutathione Heterogeneous Imaging[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2021,17(7):1339-1348.
APA	Wang, Yaqin.,Shang, Wenting.,Xiong, Jianping.,Liu, Yu.,Luo, Ting.,...&Xu, Ke.(2021).Activable Nanoparticle for Tumor Aggressiveness and Drug Resistance Prediction by Glutathione Heterogeneous Imaging.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,17(7),1339-1348.
MLA	Wang, Yaqin,et al."Activable Nanoparticle for Tumor Aggressiveness and Drug Resistance Prediction by Glutathione Heterogeneous Imaging".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 17.7(2021):1339-1348.