Knowledge Commons of Institute of Automation,CAS
Fully automated grading system for the evaluation of punctate epithelial erosions using deep neural networks | |
Qu, Jing-Hao1,2; Qin, Xiao-Ran3; Li, Chen-Di1,2; Peng, Rong-Mei1,2; Xiao, Ge-Ge1,2; Cheng, Jian3; Gu, Shao-Feng1,2; Wang, Hai-Kun1,2; Hong, Jing1,2 | |
发表期刊 | BRITISH JOURNAL OF OPHTHALMOLOGY |
ISSN | 0007-1161 |
2021-10-20 | |
页码 | 8 |
通讯作者 | Hong, Jing(hongjing196401@163.com) |
摘要 | Purpose The goal was to develop a fully automated grading system for the evaluation of punctate epithelial erosions (PEEs) using deep neural networks. Methods A fully automated system was developed to detect corneal position and grade staining severity given a corneal fluorescein staining image. The fully automated pipeline consists of the following three steps: a corneal segmentation model extracts corneal area; five image patches are cropped from the staining image based on the five subregions of extracted cornea; a staining grading model predicts a score for each image patch from 0 to 3, and automated grading score for the whole cornea is obtained from 0 to 15. Finally, the clinical grading scores annotated by three ophthalmologists were compared with automated grading scores. Results For corneal segmentation, the segmentation model achieved an intersection over union of 0.937. For punctate staining grading, the grading model achieved a classification accuracy of 76.5% and an area under the receiver operating characteristic curve of 0.940 (95% CI 0.932 to 0.949). For the fully automated pipeline, Pearson's correlation coefficient between the clinical and automated grading scores was 0.908 (p<0.01). Bland-Altman analysis revealed 95% limits of agreement between the clinical and automated grading scores of between -4.125 and 3.720 (concordance correlation coefficient=0.904). The average time required for processing a single stained image during pipeline was 0.58 s. Conclusion A fully automated grading system was developed to evaluate PEEs. The grading results may serve as a reference for ophthalmologists in clinical trials and residency training procedures. |
关键词 | cornea imaging |
DOI | 10.1136/bjophthalmol-2021-319755 |
关键词[WOS] | CORNEAL ; QUANTIFICATION |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[81970768] ; National Natural Science Foundation of China[81800801] ; China National Key Research and Development Program[2020AAA0105004] |
项目资助者 | National Natural Science Foundation of China ; China National Key Research and Development Program |
WOS研究方向 | Ophthalmology |
WOS类目 | Ophthalmology |
WOS记录号 | WOS:000721845700001 |
出版者 | BMJ PUBLISHING GROUP |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/46492 |
专题 | 复杂系统认知与决策实验室_高效智能计算与学习 |
通讯作者 | Hong, Jing |
作者单位 | 1.Peking Univ Third Hosp, Dept Ophthalmol, Beijing, Peoples R China 2.Peking Univ Third Hosp, Beijing Key Lab Restorat Damaged Ocular Nerve, Beijing, Peoples R China 3.Chinese Acad Sci, Res Ctr Brain Inspired Intelligence, Inst Automat, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Qu, Jing-Hao,Qin, Xiao-Ran,Li, Chen-Di,et al. Fully automated grading system for the evaluation of punctate epithelial erosions using deep neural networks[J]. BRITISH JOURNAL OF OPHTHALMOLOGY,2021:8. |
APA | Qu, Jing-Hao.,Qin, Xiao-Ran.,Li, Chen-Di.,Peng, Rong-Mei.,Xiao, Ge-Ge.,...&Hong, Jing.(2021).Fully automated grading system for the evaluation of punctate epithelial erosions using deep neural networks.BRITISH JOURNAL OF OPHTHALMOLOGY,8. |
MLA | Qu, Jing-Hao,et al."Fully automated grading system for the evaluation of punctate epithelial erosions using deep neural networks".BRITISH JOURNAL OF OPHTHALMOLOGY (2021):8. |
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