X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis

doi:10.14336/AD.2022.0824

CASIA OpenIR > 多模态人工智能系统全国重点实验室 > 计算生物学与机器智能

	X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis
	Wang, Tao 1,2; Zhou, Jia 3; Zhang, Xiao 1,2; Wu, Yujie 4; Jin, Kehan 3; Wane, Yilin 7,8; Xu, Ran1,2 ; Yang, Ge 4,5; Li, Wenjing4,5 ; Jiao, Liqun 1,2,6
发表期刊	AGING AND DISEASE
ISSN	2152-5250
	2022-08-25
页码	20
通讯作者	Yang, Ge(ge.yang@ia.ac.cn) ; Li, Wenjing(wenjing.li@ia.ac.cn) ; Jiao, Liqun(liqunjiao@sina.cn)
摘要	Atherosclerosis (AS), the formation of fibrofatty lesions in the vessel wall, is the primary cause of heart disease and stroke and is closely associated with aging. Disrupted metabolic homeostasis is a primary feature of AS and leads to endoplasmic reticulum (ER) stress, which is an abnormal accumulation of unfolded proteins. By orchestrating signaling cascades of the unfolded protein response (UPR), ER stress functions as a double-edged sword in AS, where adaptive UPR triggers synthetic metabolic processes to restore homeostasis, whereas the maladaptive response programs the cell to the apoptotic pathway. However, little is known regarding their precise coordination. Herein, an advanced understanding of the role of UPR in the pathological process of AS is reviewed. In particular, we focused on a critical mediator of the UPR, X-box binding protein 1 (XBP1), and its important role in balancing adaptive and maladaptive responses. The XBP1 mRNA is processed from the unspliced isoform (XBP1u) to the spliced isoform of XBP1 (XBP1s). Compared with XBP1u, XBP1s predominantly functions downstream of inositol-requiring enzyme-1?? (IRE1??) and transcript genes involved in protein quality control, inflammation, lipid metabolism, carbohydrate metabolism, and calcification, which are critical for the pathogenesis of AS. Thus, the IRE1??/XBP1 axis is a promising pharmaceutical candidate against AS.
关键词	Endoplasmic Reticulum Stress Unfolded Protein Response XBP1 IRE1? Atherosclerosis
DOI	10.14336/AD.2022.0824
关键词[WOS]	ENDOPLASMIC-RETICULUM STRESS ; SMOOTH-MUSCLE-CELLS ; ENDOTHELIAL GROWTH-FACTOR ; RESPONSE ACTIVATOR PXBP1(S) ; TRANSCRIPTION FACTOR 4 ; ER STRESS ; MESSENGER-RNA ; IRE1-ALPHA-XBP1 PATHWAY ; MYOCARDIAL-INFARCTION ; GLUCOSE-HOMEOSTASIS
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[821 71303] ; Beijing Municipal Science & Technology Commission[5202022]
项目资助者	National Natural Science Foundation of China ; Beijing Municipal Science & Technology Commission
WOS研究方向	Geriatrics & Gerontology
WOS类目	Geriatrics & Gerontology
WOS记录号	WOS:000848057600001
出版者	INT SOC AGING & DISEASE
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/50051
专题	多模态人工智能系统全国重点实验室_计算生物学与机器智能
通讯作者	Yang, Ge; Li, Wenjing; Jiao, Liqun
作者单位	1.Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China 2.China Int Neurosci Inst China INI, Beijing, Peoples R China 3.Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Lab Computat Biol & Machine Intelligence, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 6.Capital Med Univ, Xuanwu Hosp, Dept Intervent Radiol, Beijing, Peoples R China 7.Capital Med Univ, Xuanwu Hosp, Inst Cerebrovasc Dis Res, Beijing, Peoples R China 8.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
通讯作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Wang, Tao,Zhou, Jia,Zhang, Xiao,et al. X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis[J]. AGING AND DISEASE,2022:20.
APA	Wang, Tao.,Zhou, Jia.,Zhang, Xiao.,Wu, Yujie.,Jin, Kehan.,...&Jiao, Liqun.(2022).X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis.AGING AND DISEASE,20.
MLA	Wang, Tao,et al."X-box Binding Protein 1: An Adaptor in the Pathogenesis of Atherosclerosis".AGING AND DISEASE (2022):20.