Anisotropic hydrogel fabricated by controlled diffusion as a bio-scaffold for the regeneration of cartilage injury

doi:10.1039/d2ra05141a

CASIA OpenIR > 多模态人工智能系统全国重点实验室 > 生物识别与安全技术

	Anisotropic hydrogel fabricated by controlled diffusion as a bio-scaffold for the regeneration of cartilage injury
	Yu, Xiaotian 1,2,3; Deng, Zhantao 1; Li, Han 1,2; Ma, Yuanchen 1; Ma, Xibo3,4 ; Zheng, Qiujian 1,5
发表期刊	RSC ADVANCES
	2022-09-28
卷号	12 期号:43 页码:28254-28263
通讯作者	Zheng, Qiujian(zhengqiujian@gdph.org.cn)
摘要	Controlled fabrication of anisotropic materials has become a hotspot in materials science, particularly biomaterials, since the next generation of tissue engineering is based on the application of heterogeneous structures that can simulate the original biological complexity of the body. The current fabrication method of producing anisotropic materials involves expensive and highly specialized equipment, and not every conventional method can be applied to preparing anisotropic materials for corresponding tissue engineering. Anisotropic materials can be easily applied to a problem in tissue engineering: cartilage injury repairing. The articular cartilage consists of four spatially distinct regions: superficial, transitional, deep, and calcified. Each region has a specific extracellular matrix composition, mechanical properties, and cellular organization; this calls for the application of an anisotropic hydrogel. Controlled diffusion, under the assistance of buoyancy, has been considered a generalized method to prepare materials using a gradient. The diffusion of two solutions can be controlled through the difference in their densities. In addition to providing anisotropy, this method realizes the in situ formation of an anisotropic hydrogel, and simplifies the preparation process, freeing it from the need for expensive equipment such as 3D printing and microfluidics. Herein, an anisotropic hydrogel based on a decellularized extracellular matrix is fabricated and characterized. The as-prepared scaffold possessed specific chemical composition, physical properties, and physiological factor gradient. In vitro experiments ensured its biocompatibility and biological effectiveness; further in vivo experiments confirmed its application in the effective regeneration of cartilage injury.
DOI	10.1039/d2ra05141a
关键词[WOS]	RAT MENISCUS ; MATRIX ; CELLS ; TISSUES
收录类别	SCI
语种	英语
资助项目	Natural Science Foundation of Guangdong Province[2022A1515011306] ; Natural Science Foundation of Guangdong Province[2020A1515010268] ; Natural Science Foundation of Guangdong Province[2021A1515011008] ; Outstanding Young Talents Foundation of Guangdong Provincial People's Hospital[KJ012019091] ; Program of Science and Technology of Guangzhou[202103020166] ; Program of Science and Technology of Guangzhou[201904010424] ; Program of Science and Technology of Guangzhou[202102020924] ; Program of Science and Technology of Guangzhou[202201011229] ; NSFC Incubation Project of Guangdong Provincial People's Hospital[KY0120220031] ; Fundamental Research Funds for the Central Universities[2020ZYGXZR010]
项目资助者	Natural Science Foundation of Guangdong Province ; Outstanding Young Talents Foundation of Guangdong Provincial People's Hospital ; Program of Science and Technology of Guangzhou ; NSFC Incubation Project of Guangdong Provincial People's Hospital ; Fundamental Research Funds for the Central Universities
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000864396900001
出版者	ROYAL SOC CHEMISTRY
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/50318
专题	多模态人工智能系统全国重点实验室_生物识别与安全技术
通讯作者	Zheng, Qiujian
作者单位	1.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Orthoped, Guangzhou, Peoples R China 2.Guangdong Cardiovasc Inst, Guangzhou, Guangdong, Peoples R China 3.Chinese Acad Sci, Inst Automat, CBSR&NLPR, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 5.Southern Med Univ, Sch Clin Med 2, Guangzhou, Peoples R China
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Yu, Xiaotian,Deng, Zhantao,Li, Han,et al. Anisotropic hydrogel fabricated by controlled diffusion as a bio-scaffold for the regeneration of cartilage injury[J]. RSC ADVANCES,2022,12(43):28254-28263.
APA	Yu, Xiaotian,Deng, Zhantao,Li, Han,Ma, Yuanchen,Ma, Xibo,&Zheng, Qiujian.(2022).Anisotropic hydrogel fabricated by controlled diffusion as a bio-scaffold for the regeneration of cartilage injury.RSC ADVANCES,12(43),28254-28263.
MLA	Yu, Xiaotian,et al."Anisotropic hydrogel fabricated by controlled diffusion as a bio-scaffold for the regeneration of cartilage injury".RSC ADVANCES 12.43(2022):28254-28263.