| Effect of schizophrenia risk gene polymorphisms on cognitive and neural plasticity | |
Zhao, Wan1; Zhang, Qiumei2,3,4; Su, Yanyan2,3; Chen, Xiongying5,6,7; Li, Xiaohong5,6,7; Du, Boqi2,3; Deng, Xiaoxiang2,3; Ji, Feng8; Li, Jin9,10 ; Dong, Qi2,3; Chen, Chuansheng11; Li, Jun2,3
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| 发表期刊 | SCHIZOPHRENIA RESEARCH
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| ISSN | 0920-9964 |
| 2022-10-01 | |
| 卷号 | 248页码:173-179 |
| 通讯作者 | Li, Jun(lijundp@bnu.edu.cn) |
| 摘要 | A recent Chinese genome-wide association study found evidence for 58 out of the 128 schizophrenia-associated variants previously discovered in Western samples by the Schizophrenia Working Group of the Psychiatric Ge-nomics Consortium (PGC). However, the functional impact of these trans-ancestry genome-wide single -nucleotide polymorphisms (SNPs) is not clear. In the current study, we examined the roles of trans-ancestry SNPs in cognitive and neural plasticity. We first performed a behavioral study of 547 healthy volunteers, who received month-long working memory training, and working memory capability assessment both before and after the training. A separate sample of 101 subjects received the same training and received fMRI scans during a working memory task, both before and after the training. The behavioral study found a significant association between the polygenic risk score (PRS) and behavioral plasticity, with higher schizophrenia risk scores being linked to less plasticity. At the SNP level, rs36068923 showed a significant signal, with the risk allele being associated with less plasticity. The fMRI study further found that the PRS and rs36068923 polymorphism were associated with training-induced changes in striatal activation, with higher PRS and the risk allele of rs36068923 being linked to less brain plasticity. In sum, this study found that a high genetic risk for schizophrenia was associated with less plasticity at both behavioral and neural levels. These results provide new insights into the neural and cognitive mechanisms linking genes to schizophrenia. |
| 关键词 | Schizophrenia Working memory training fMRI Plasticity Gene Polymorphism |
| DOI | 10.1016/j.schres.2022.08.014 |
| 关键词[WOS] | WORKING-MEMORY ; PREFRONTAL CORTEX ; BRAIN ACTIVITY ; DYSFUNCTION ; PSYCHOSIS ; DYNAMICS ; KV8.1 ; MODEL ; LOCI ; SHAB |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | National Natural Science Foundation of China[31771242] ; National Natural Science Foundation of China[81571045] ; National Natural Science Foundation cultivation project of Jining Medical University[JYP201713] ; Supporting Fund for Teachers'research of Jining Medical University[JYFC2018KJ002] ; Open Research Fund of the State Key Laboratory of Cognitive Neuro- science and Learning |
| 项目资助者 | National Natural Science Foundation of China ; National Natural Science Foundation cultivation project of Jining Medical University ; Supporting Fund for Teachers'research of Jining Medical University ; Open Research Fund of the State Key Laboratory of Cognitive Neuro- science and Learning |
| WOS研究方向 | Psychiatry |
| WOS类目 | Psychiatry |
| WOS记录号 | WOS:000863054000013 |
| 出版者 | ELSEVIER |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/50386 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 通讯作者 | Li, Jun |
| 作者单位 | 1.Nanjing Normal Univ, Sch Psychol, Nanjing 210097, Jiangsu, Peoples R China 2.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 3.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China 4.Jining Med Univ, Sch Publ Hlth, Jining 272013, Shandong, Peoples R China 5.Capital Med Univ, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China 6.Capital Med Univ, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China 7.Capital Med Univ, Beijing Anding Hosp, Adv Innovat Ctr Human Brain Protect, Sch Mental Hlth, Beijing 100088, Peoples R China 8.Jining Med Univ, Sch Mental Hlth, Jining 272013, Shandong, Peoples R China 9.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, 95 East Zhongguancun Rd, Beijing 100190, Peoples R China 10.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, 95 East Zhongguancun Rd, Beijing 100190, Peoples R China 11.Univ Calif Irvine, Dept Psychol Sci, Irvine, CA 92697 USA |
| 推荐引用方式 GB/T 7714 | Zhao, Wan,Zhang, Qiumei,Su, Yanyan,et al. Effect of schizophrenia risk gene polymorphisms on cognitive and neural plasticity[J]. SCHIZOPHRENIA RESEARCH,2022,248:173-179. |
| APA | Zhao, Wan.,Zhang, Qiumei.,Su, Yanyan.,Chen, Xiongying.,Li, Xiaohong.,...&Li, Jun.(2022).Effect of schizophrenia risk gene polymorphisms on cognitive and neural plasticity.SCHIZOPHRENIA RESEARCH,248,173-179. |
| MLA | Zhao, Wan,et al."Effect of schizophrenia risk gene polymorphisms on cognitive and neural plasticity".SCHIZOPHRENIA RESEARCH 248(2022):173-179. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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