| Unruptured brain arteriovenous malformations causing seizures localize to one common brain network | |
Zhao, Shao-Zhi1,2; Zhao, Yu-Xin3,4,5; Liao, Xiao-Hua3,4,5 ; Huo, Ran1,2; Li, Hao1,2; Jiao, Yu-Ming1,2; Weng, Jian-Cong1,2; Wang, Jie1,2; Liu, Bing6,7; Cao, Yong1,2
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| Source Publication | JOURNAL OF NEUROSCIENCE RESEARCH
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| ISSN | 0360-4012 |
| 2022-11-07 | |
| Pages | 11 |
| Corresponding Author | Liu, Bing(bing.liu@bnu.edu.cn) ; Cao, Yong(caoyong@bjtth.org) |
| Abstract | Seizures are a frequent symptom of unruptured brain arteriovenous malformations (bAVMs). However, the brain regions responsible for these seizures remain unclear. To identify the brain regions causally involved in bAVM-related seizures, we retrospectively reviewed 220 patients with unruptured bAVMs. Using voxel-based lesion-symptom mapping (VLSM) analyses, we tested whether individual brain regions were associated with unruptured bAVM-related seizures. The result revealed that unruptured bAVMs causing seizures are anatomically heterogeneous at the voxel level. Subsequently, lesion network mapping (LNM) analyses was performed to determine whether bAVMs causing seizures belonged to a distributed brain network. LNM analyses indicated that these lesions were located in a functional network characterized by connectivity to the left caudate and precuneus. Moreover, the discrimination performance of the identified seizure network was evaluated in discovery set by calculating the individualized network damage score and was tested in validation set. Based on the calculated network damage scores, patients were divided into low-, medium-, and high-risk groups. The prevalence of seizures significantly differed among the three risk categories in both discovery (p = .003) and validation set (p = .004). Finally, we calculated the percentage of voxels in the canonical resting-state networks that overlapped with the seizure-susceptible brain regions to investigate the involvement of resting-state networks. With an involvement percentage over 50%, the frontoparietal control (82.9%), limbic function (76.7%), and default mode network (69.3%) were considered to be impacted in bAVM-related seizures. Our study identified the seizure-susceptible brain regions for unruptured bAVMs, which could be a plausible neuroimaging biomarker in predicting possible seizures. |
| Keyword | brain arteriovenous malformations lesion network mapping seizures voxel-based lesion-symptom mapping |
| DOI | 10.1002/jnr.25142 |
| WOS Keyword | DEFAULT MODE NETWORK ; INTERNATIONAL-LEAGUE ; EPILEPSY ; ILAE ; ABNORMALITIES |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National key research and development program of China during the 13th Five-Year Plan Period[2016YFC1301803] |
| Funding Organization | National key research and development program of China during the 13th Five-Year Plan Period |
| WOS Research Area | Neurosciences & Neurology |
| WOS Subject | Neurosciences |
| WOS ID | WOS:000879711500001 |
| Publisher | WILEY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/50673 |
| Collection | 脑网络组研究 |
| Corresponding Author | Liu, Bing; Cao, Yong |
| Affiliation | 1.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, 119 South Fourth Ring Rd West, Beijing 100070, Peoples R China 2.China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China 3.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China 4.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China 5.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 6.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 7.Chinese Inst Brain Res, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Zhao, Shao-Zhi,Zhao, Yu-Xin,Liao, Xiao-Hua,et al. Unruptured brain arteriovenous malformations causing seizures localize to one common brain network[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2022:11. |
| APA | Zhao, Shao-Zhi.,Zhao, Yu-Xin.,Liao, Xiao-Hua.,Huo, Ran.,Li, Hao.,...&Cao, Yong.(2022).Unruptured brain arteriovenous malformations causing seizures localize to one common brain network.JOURNAL OF NEUROSCIENCE RESEARCH,11. |
| MLA | Zhao, Shao-Zhi,et al."Unruptured brain arteriovenous malformations causing seizures localize to one common brain network".JOURNAL OF NEUROSCIENCE RESEARCH (2022):11. |
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