Biomimetic camouflaged nanoparticle-based folfirinox platform for optimizing clinical pancreatic cancer treatment

doi:10.1016/j.nantod.2022.101733

	Biomimetic camouflaged nanoparticle-based folfirinox platform for optimizing clinical pancreatic cancer treatment
	Wang, Qian1,2 ; Wang, Zihua 3; Li, Zhangfu 4,5; Li, Dan6 ; He, Fangfei 7; Wang, Kun2 ; Tian, Jie 2; Zhao, Xinming 1
发表期刊	NANO TODAY
ISSN	1748-0132
	2023-02-01
卷号	48 页码:11
通讯作者	Wang, Zihua(wangzh@fjmu.edu.cn) ; Wang, Kun(kun.wang@ia.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Zhao, Xinming(xinmingzh2017@yeah.net)
摘要	The most effective treatment of pancreatic cancer (PC) is known as mFOLFIRINOX scheme. However, this regimen has relatively severe toxic effects and are commonly restricted to patients with sound physique, which is poor in drug-selectivity, non-specific causing serious toxicity, greatly limits clinical application. Safer and more effective strategy seamlessly and synchronously is needed as advanced treatments for pancreatic cancer in future. In this report, we exploit a biomimetic nanoparticle-based platform for optimizing mFOL-FIRINOX regimen. By coating pancreatic cancer cell membrane (PCCM) onto the surface of polymeric cores that loaded with mFOLFIRINOX, we prepare PCCM-cloaked nanoparticles, namely CNP@folfirinox, which inherit the antigenic exterior structure and associated functions of PC cells. The resulting CNP@folfirinox displays a core-shell nanostructure, which consisting of polymeric core and cancer cell membrane shell with suitable size and surface charge. Particularly, owing to inheriting the inherent membrane protein expressions profile, CNP@folfirinox exhibits prominent advantages in homologous homing to tumor tissue and deep penetration. It also shows lower side effects compared to extensive mFOLFIRINOX i.v. administration with no appreciable toxicity in other organs outside the tumor in vivo. Meanwhile, CNP@folfirinox is endowed with the "Don't eat me" privilege, hard for the immune system to recognize and less reticuloendothelial system uptake, with prolonged blood circulation, therefore improving delivery efficiency of drug after intravenous administration. Thus, this work reshapes a promising paradigm for more safe and more effective mFOLFIR-INOX strategy for further clinical pancreatic cancer treatment. (c) 2022 Elsevier Ltd. All rights reserved.
关键词	Pancreatic cancer MFOLFIRINOX regimen Cell membrane biomimetic platform Drug delivery Multimodal visualization
DOI	10.1016/j.nantod.2022.101733
关键词[WOS]	DRUG-DELIVERY ; TOLERABILITY ; COMBINATION ; EFFICACY
收录类别	SCI
语种	英语
资助项目	Ministry of Science and Technology of China[2017YFA0205200] ; National Natural Science Foundation of China[81901813] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[92159305] ; CAMS Innovation Fund for Medical Science[2021-I2M-CT-B-067] ; Joint Funds for the Innovation of Science and Technology Fujian Province[2019Y9001]
项目资助者	Ministry of Science and Technology of China ; National Natural Science Foundation of China ; CAMS Innovation Fund for Medical Science ; Joint Funds for the Innovation of Science and Technology Fujian Province
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:000911494900001
出版者	ELSEVIER SCI LTD
引用统计	被引频次：5[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/51055
专题	中国科学院分子影像重点实验室
通讯作者	Wang, Zihua; Wang, Kun; Tian, Jie; Zhao, Xinming
作者单位	1.Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, Dept Diagnost Imaging, Beijing 100021, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Fujian Med Univ, Sch Basic Med Sci, Fujian Prov Key Lab Brain Aging & Neurodegenerat D, Fuzhou 350122, Fujian, Peoples R China 4.Hong Kong Univ Sci, Shenzhen Peking Univ, Shenzhen Hosp, Dept Hepatopancreato Biliary Surg, Guangzhou 518036, Peoples R China 5.Technol Med Ctr, Guangzhou 518036, Peoples R China 6.Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Canc Ctr, State Key Lab Mol Oncol, Beijing 100021, Peoples R China 7.Natl Ctr Nanosci & Technol NCNST, CAS Ctr Excellence Nanosci, CAS Key Lab Biol Effects Nanomat Nanosafety, Beijing 100190, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Wang, Qian,Wang, Zihua,Li, Zhangfu,et al. Biomimetic camouflaged nanoparticle-based folfirinox platform for optimizing clinical pancreatic cancer treatment[J]. NANO TODAY,2023,48:11.
APA	Wang, Qian.,Wang, Zihua.,Li, Zhangfu.,Li, Dan.,He, Fangfei.,...&Zhao, Xinming.(2023).Biomimetic camouflaged nanoparticle-based folfirinox platform for optimizing clinical pancreatic cancer treatment.NANO TODAY,48,11.
MLA	Wang, Qian,et al."Biomimetic camouflaged nanoparticle-based folfirinox platform for optimizing clinical pancreatic cancer treatment".NANO TODAY 48(2023):11.