Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Excitation-based fully connected network for precise NIR-II fluorescence molecular tomography | |
Cao, Caiguang1,2![]() ![]() ![]() ![]() ![]() | |
发表期刊 | BIOMEDICAL OPTICS EXPRESS
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ISSN | 2156-7085 |
2022-12-01 | |
卷号 | 13期号:12页码:6284-6299 |
摘要 | Fluorescence molecular tomography (FMT) is a novel imaging modality to obtain matical model and complicated inverse problem limit it to achieving precise results. In this study, the second near-infrared (NIR-II) fluorescence imaging was adopted to mitigate tissue scattering and reduce noise interference. An excitation-based fully connected network was proposed to model the inverse process of NIR-II photon propagation and directly obtain the 3D distribution of the light source. An excitation block was embedded in the network allowing it to autonomously pay more attention to neurons related to the light source. The barycenter error was added to the loss function to improve the localization accuracy of the light source. Both numerical simulation and in vivo experiments showed the superiority of the novel NIR-II FMT reconstruction strategy over the baseline methods. This strategy was expected to facilitate the application of machine learning in biomedical research. |
DOI | 10.1364/BOE.474982Journal |
关键词[WOS] | RECONSTRUCTION ; SIMULATION ; MOUSE ; REGULARIZATION ; OPTIMIZATION ; SYSTEM ; MODEL |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[92059207] ; National Natural Science Foundation of China[81227901] ; Beijing Natural Science Foundation[JQ19027] ; CAS Youth Interdisciplinary Team[JCTD-2021-08] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16021200] ; Zhuhai High-level Health Personnel Team Project[Zhuhai HLHPTP201703] |
项目资助者 | National Key Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; CAS Youth Interdisciplinary Team ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Zhuhai High-level Health Personnel Team Project |
WOS研究方向 | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000917262200009 |
出版者 | Optica Publishing Group |
七大方向——子方向分类 | 医学影像处理与分析 |
国重实验室规划方向分类 | 实体人工智能系统(软、硬件) |
是否有论文关联数据集需要存交 | 否 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/51411 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Hu, Zhenhua |
作者单位 | 1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 3.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Engn Med, Beijing, Peoples R China 4.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Sch Life Sci & Technol, Minist Educ, Xian, Peoples R China |
第一作者单位 | 中国科学院自动化研究所 |
通讯作者单位 | 中国科学院自动化研究所 |
推荐引用方式 GB/T 7714 | Cao, Caiguang,Xiao, Anqi,Cai, Meishan,et al. Excitation-based fully connected network for precise NIR-II fluorescence molecular tomography[J]. BIOMEDICAL OPTICS EXPRESS,2022,13(12):6284-6299. |
APA | Cao, Caiguang.,Xiao, Anqi.,Cai, Meishan.,Shen, Biluo.,Guo, Lishuang.,...&Hu, Zhenhua.(2022).Excitation-based fully connected network for precise NIR-II fluorescence molecular tomography.BIOMEDICAL OPTICS EXPRESS,13(12),6284-6299. |
MLA | Cao, Caiguang,et al."Excitation-based fully connected network for precise NIR-II fluorescence molecular tomography".BIOMEDICAL OPTICS EXPRESS 13.12(2022):6284-6299. |
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