CASIA OpenIR  > 中国科学院分子影像重点实验室
Excitation-based fully connected network for precise NIR-II fluorescence molecular tomography
Cao, Caiguang1,2; Xiao, Anqi1,2; Cai, Meishan1,2; Shen, Biluo1,2; Guo, Lishuang1,3; Shi, Xiaojing1,2; Tian, Jie1,2,3,4; Hu, Zhenhua1,2
Source PublicationBIOMEDICAL OPTICS EXPRESS
ISSN2156-7085
2022-12-01
Volume13Issue:12Pages:6284-6299
Abstract

Fluorescence molecular tomography (FMT) is a novel imaging modality to obtain matical model and complicated inverse problem limit it to achieving precise results. In this study, the second near-infrared (NIR-II) fluorescence imaging was adopted to mitigate tissue scattering and reduce noise interference. An excitation-based fully connected network was proposed to model the inverse process of NIR-II photon propagation and directly obtain the 3D distribution of the light source. An excitation block was embedded in the network allowing it to autonomously pay more attention to neurons related to the light source. The barycenter error was added to the loss function to improve the localization accuracy of the light source. Both numerical simulation and in vivo experiments showed the superiority of the novel NIR-II FMT reconstruction strategy over the baseline methods. This strategy was expected to facilitate the application of machine learning in biomedical research.

DOI10.1364/BOE.474982Journal
WOS KeywordRECONSTRUCTION ; SIMULATION ; MOUSE ; REGULARIZATION ; OPTIMIZATION ; SYSTEM ; MODEL
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[92059207] ; National Natural Science Foundation of China[81227901] ; Beijing Natural Science Foundation[JQ19027] ; CAS Youth Interdisciplinary Team[JCTD-2021-08] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16021200] ; Zhuhai High-level Health Personnel Team Project[Zhuhai HLHPTP201703]
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; CAS Youth Interdisciplinary Team ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Zhuhai High-level Health Personnel Team Project
WOS Research AreaBiochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectBiochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000917262200009
PublisherOptica Publishing Group
Sub direction classification医学影像处理与分析
planning direction of the national heavy laboratory实体人工智能系统(软、硬件)
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Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/51411
Collection中国科学院分子影像重点实验室
Corresponding AuthorHu, Zhenhua
Affiliation1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing Key Lab Mol Imaging, Beijing, Peoples R China
2.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China
3.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Engn Med, Beijing, Peoples R China
4.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Sch Life Sci & Technol, Minist Educ, Xian, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Automation, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Cao, Caiguang,Xiao, Anqi,Cai, Meishan,et al. Excitation-based fully connected network for precise NIR-II fluorescence molecular tomography[J]. BIOMEDICAL OPTICS EXPRESS,2022,13(12):6284-6299.
APA Cao, Caiguang.,Xiao, Anqi.,Cai, Meishan.,Shen, Biluo.,Guo, Lishuang.,...&Hu, Zhenhua.(2022).Excitation-based fully connected network for precise NIR-II fluorescence molecular tomography.BIOMEDICAL OPTICS EXPRESS,13(12),6284-6299.
MLA Cao, Caiguang,et al."Excitation-based fully connected network for precise NIR-II fluorescence molecular tomography".BIOMEDICAL OPTICS EXPRESS 13.12(2022):6284-6299.
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