Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Enhanced glypican-3-targeted identification of hepatocellular carcinoma with liver fibrosis by pre-degrading excess fibrotic collagen | |
Zhuo, Jiaming1,2,3; Wang, Yueqi2![]() ![]() | |
发表期刊 | Acta Biomaterialia
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2023 | |
卷号 | 158页码:435- 448 |
文章类型 | SCI |
摘要 | Most hepatocellular carcinomas (HCCs) occur in cirrhotic livers, but unequivocal diagnosis of early HCC from the fibrotic microenvironment remains a formidable challenge with conventional imaging strate- gies, mainly because of the massive fibrotic collagen deposition leading to hepatic nodules formation and dysfunction of contrast agent metabolism. Here, we developed a “sweep-and-illuminate”imaging strat- egy, pre-degrade hepatic fibrotic collagen with collagenase I conjugated human serum albumin (HSA- C) and then targeting visualize HCC lesion with GPC3 targeting nanoparticles (TSI NPs, TJ2 peptide–superparamagnetic iron oxide–indocyanine green) via fluorescence imaging (FLI) and magnetic parti- cle imaging (MPI). TSI NPs delineated a clear boundary of HCC and normal liver, and the tumor-to- background ratios (TBRs) detected by FLI and MPI were 5.43- and 1.34-fold higher than the non-targeted group, respectively. HSA-C could degrade 24.7% fibrotic collagen, followed by 27.2% reduction of nonspe- cific NPs retention in mice with liver fibrosis. In a pathological state in which HCC occurs in the fibrotic microenvironment, HSA-C-mediated pre-degradation of fibrotic collagen reduced background signal in- terference in fibrotic tissues and enhanced the intratumoral uptake of TSI NPs, resulting in the clear demarcation between HCC and liver fibrosis, and the TBR was increased 2.61-fold compared to the group without HSA-C pretreatment. We demonstrated the feasibility of combined pre-degradation of fibrotic collagen and application of a GPC3-targeted FLI/MPI contrast agent for early HCC identification, as well as its clinical value in the management of patients with advanced liver fibrosis. |
收录类别 | SCI |
语种 | 英语 |
七大方向——子方向分类 | 其他 |
国重实验室规划方向分类 | 其他 |
是否有论文关联数据集需要存交 | 否 |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/51617 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Fang, Chihua; Tian, Jie |
作者单位 | 1.Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 2.CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chines Academy of Sciences, Beijing 3.Guangdong Provincial Clinical and Engineering Center of Digital Medicine, Guangzhou 510280 4.School of Engineering Medicine & School of Biological Science and Medical Engineering, Beihang University 5.University of Chinese Academy of Sciences 6.Pazhou Lab, Guangzhou 7.Zhuhai Precision Medical Center, Zhuhai People’s Hospital, affiliated with Jinan University |
推荐引用方式 GB/T 7714 | Zhuo, Jiaming,Wang, Yueqi,Hui, Hui,et al. Enhanced glypican-3-targeted identification of hepatocellular carcinoma with liver fibrosis by pre-degrading excess fibrotic collagen[J]. Acta Biomaterialia,2023,158:435- 448. |
APA | Zhuo, Jiaming.,Wang, Yueqi.,Hui, Hui.,Li, Changjian.,Yang, Junying.,...&Tian, Jie.(2023).Enhanced glypican-3-targeted identification of hepatocellular carcinoma with liver fibrosis by pre-degrading excess fibrotic collagen.Acta Biomaterialia,158,435- 448. |
MLA | Zhuo, Jiaming,et al."Enhanced glypican-3-targeted identification of hepatocellular carcinoma with liver fibrosis by pre-degrading excess fibrotic collagen".Acta Biomaterialia 158(2023):435- 448. |
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