Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging

doi:10.1002/wsbm.1612

	Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging
	Li, Wenjing 1,2; Pang, Yiyun 3; Jin, Kehan 3; Wang, Yuru 3; Wu, Yujie 1; Luo, Jichang 4,5; Xu, Wenlong 4,5; Zhang, Xiao 4,5; Xu, Ran4,5 ; Wang, Tao4,5 ; Jiao, Liqun 4,5,6
发表期刊	WIRES MECHANISMS OF DISEASE
ISSN	2692-9368
	2023-05-08
页码	24
通讯作者	Xu, Ran(xrqssq@126.com) ; Wang, Tao(wangtao_dr@sina.com) ; Jiao, Liqun(liqunjiao@sina.cn)
摘要	Chronological age causes structural and functional vascular deterioration and is a well-established risk factor for the development of cardiovascular diseases, leading to more than 40% of all deaths in the elderly. The etiology of vascular aging is complex; a significant impact arises from impaired cholesterol homeostasis. Cholesterol level is balanced through synthesis, uptake, transport, and esterification, the processes executed by multiple organelles. Moreover, organelles responsible for cholesterol homeostasis are spatially and functionally coordinated instead of isolated by forming the membrane contact sites. Membrane contact, mediated by specific protein-protein interaction, pulls opposing organelles together and creates the hybrid place for cholesterol transfer and further signaling. The membrane contact-dependent cholesterol transfer, together with the vesicular transport, maintains cholesterol homeostasis and has intimate implications in a growing list of diseases, including vascular aging-related diseases. Here, we summarized the latest advances regarding cholesterol homeostasis by highlighting the membrane contact-based regulatory mechanism. We also describe the downstream signaling under cholesterol homeostasis perturbations, prominently in cholesterol-rich conditions, stimulating age-dependent organelle dysfunction and vascular aging. Finally, we discuss potential cholesterol-targeting strategies for therapists regarding vascular aging-related diseases.This article is categorized under:Cardiovascular Diseases > Molecular and Cellular Physiology
关键词	cardiovascular diseases cellular organelles cholesterol membrane contact sites vascular aging
DOI	10.1002/wsbm.1612
关键词[WOS]	FOAM CELL-FORMATION ; COOPERATIVE BINDING ; NLRP3 INFLAMMASOME ; RECEPTOR ; TRANSPORT ; MITOCHONDRIA ; ACTIVATION ; MECHANISMS ; ER ; ATHEROSCLEROSIS
收录类别	SCI
语种	英语
资助项目	Beijing Municipal Science & Technology Commission[5202022] ; National Natural Science Foundation of China[82171303] ; National Natural Science Foundation of China[91954201]
项目资助者	Beijing Municipal Science & Technology Commission ; National Natural Science Foundation of China
WOS研究方向	Research & Experimental Medicine
WOS类目	Medicine, Research & Experimental
WOS记录号	WOS:000985049100001
出版者	WILEY
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/53210
专题	多模态人工智能系统全国重点实验室
通讯作者	Xu, Ran; Wang, Tao; Jiao, Liqun
作者单位	1.Chinese Acad Sci, Inst Automat, Lab Computat Biol & Machine Intelligence, Natl Lab Pattern Recognit, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 3.Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Beijing, Peoples R China 4.Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China 5.China Int Neurosci Inst China INI, Beijing, Peoples R China 6.Capital Med Univ, Xuanwu Hosp, Dept Intervent Radiol, Beijing, Peoples R China
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Li, Wenjing,Pang, Yiyun,Jin, Kehan,et al. Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging[J]. WIRES MECHANISMS OF DISEASE,2023:24.
APA	Li, Wenjing.,Pang, Yiyun.,Jin, Kehan.,Wang, Yuru.,Wu, Yujie.,...&Jiao, Liqun.(2023).Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging.WIRES MECHANISMS OF DISEASE,24.
MLA	Li, Wenjing,et al."Membrane contact sites orchestrate cholesterol homeostasis that is central to vascular aging".WIRES MECHANISMS OF DISEASE (2023):24.