Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice

doi:10.1002/alz.13118

	Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice
	Lu, Jing 1,2; Liang, Feng 2,3,13; Bai, Ping 3,4,5; Liu, Chenghao 2,3,6; Xu, Miao 2,3,7; Sun, Zhengwang 2,3; Tian, Wenjie 3,8,9,10; Dong, Yuanlin 2,3; Zhang, Yiying 2,3; Quan, Qimin 11; Khatri, Ashok 12,13; Shen, Yuan 2,3,14,15; Marcantonio, Edward 13,16,17; Crosby, Gregory 18; Culley, Deborah J.19; Wang, Changning 3,5; Yang, Guang 20,23; Xie, Zhongcong 2,3,21,22
发表期刊	ALZHEIMERS & DEMENTIA
ISSN	1552-5260
	2023-05-30
页码	17
通讯作者	Yang, Guang(gy2268@cumc.columbia.edu) ; Xie, Zhongcong(zxie@mgh.harvard.edu)
摘要	INTRODUCTIONBlood phosphorylated tau at threonine 217 (tau-PT217) is a newly established biomarker for Alzheimer's disease and postoperative delirium in patients. However, the mechanisms and consequences of acute changes in blood tau-PT217 remain largely unknown. METHODSWe investigated the effects of anesthesia/surgery on blood tau-PT217 in aged mice, and evaluated the associated changes in B cell populations, neuronal excitability in anterior cingulate cortex, and delirium-like behavior using positron emission tomography imaging, nanoneedle technology, flow cytometry, electrophysiology, and behavioral tests. RESULTSAnesthesia/surgery induced acute increases in blood tau-PT217 via enhanced generation in the lungs and release from B cells. Tau-PT217 might cross the blood-brain barrier, increasing neuronal excitability and inducing delirium-like behavior. B cell transfer and WS635, a mitochondrial function enhancer, mitigated the anesthesia/surgery-induced changes. DISCUSSIONAcute increases in blood tau-PT217 may contribute to brain dysfunction and postoperative delirium. Targeting B cells or mitochondrial function may have therapeutic potential for preventing or treating these conditions.
关键词	anesthesia delirium phosphorylated tau at threonine 217 surgery tau tau phosphorylation
DOI	10.1002/alz.13118
关键词[WOS]	ALZHEIMERS-DISEASE ; PERMEABILITY TRANSITION ; POSTOPERATIVE DELIRIUM ; COGNITIVE DYSFUNCTION ; RISK-FACTORS ; TAU ; REDUCTION ; DEMENTIA ; DEFICITS ; CYCLOSPORINE
收录类别	SCI
语种	英语
资助项目	National Institutes of Health[AG062509] ; National Institutes of Health[AG070761] ; National Institutes of Health[AG051812] ; [AG041274]
项目资助者	National Institutes of Health
WOS研究方向	Neurosciences & Neurology
WOS类目	Clinical Neurology
WOS记录号	WOS:000997439800001
出版者	WILEY
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/53327
专题	复杂系统认知与决策实验室_听觉模型与认知计算
通讯作者	Yang, Guang; Xie, Zhongcong
作者单位	1.Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Dept Anesthesiol, Chengdu, Peoples R China 2.Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Geriatr Anesthesia Res Unit, Charlestown, MA USA 3.Harvard Med Sch, Charlestown, MA USA 4.Sichuan Univ, West China Hosp, Precis Med Key Lab Sichuan Prov, Targeted Tracer Res & Dev Lab, Chengdu, Peoples R China 5.Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Dept Radiol, Charlestown, MA USA 6.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China 7.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Anesthesiol, Guangzhou, Peoples R China 8.Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Dept Cardiol, Chengdu, Peoples R China 9.Massachusetts Gen Hosp, Cardiovasc Res Ctr, Dept Med, Charlestown, MA USA 10.Massachusetts Gen Hosp, Dept Med, Cardiol Div, Charlestown, MA USA 11.NanoMosaic Inc, Woburn, MA USA 12.Massachusetts Gen Hosp, Endocrine Unit, Boston, MA USA 13.Harvard Med Sch, Boston, MA USA 14.Tongji Univ, Sch Med, Anesthesia & Brain Res Inst, Shanghai, Peoples R China 15.Shanghai Jiao Tong Univ, Sch Med, Mental Hlth Ctr, Shanghai, Peoples R China 16.Beth Israel Deaconess Med Ctr, Dept Med, Div Gen Med & Primary Care, Boston, MA USA 17.Beth Israel Deaconess Med Ctr, Dept Med, Div Gerontol, Boston, MA USA 18.Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA USA 19.Univ Penn Hlth Syst, Perelman Sch Med, Dept Anesthesiol & Crit Care, Philadelphia, PA USA 20.Columbia Univ, Med Ctr, Dept Anesthesiol, New York, NY USA 21.Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Geriatr Anesthesia Res Unit, Anesthesia, 149 13th St,Room 4310, Charlestown, MA 02129 USA 22.Harvard Med Sch, 149 13th St,Room 4310, Charlestown, MA 02129 USA 23.Columbia Univ, Irving Med Ctr, Dept Anesthesiol, Anesthesia, New York, NY 10032 USA
推荐引用方式 GB/T 7714	Lu, Jing,Liang, Feng,Bai, Ping,et al. Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice[J]. ALZHEIMERS & DEMENTIA,2023:17.
APA	Lu, Jing.,Liang, Feng.,Bai, Ping.,Liu, Chenghao.,Xu, Miao.,...&Xie, Zhongcong.(2023).Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice.ALZHEIMERS & DEMENTIA,17.
MLA	Lu, Jing,et al."Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice".ALZHEIMERS & DEMENTIA (2023):17.