Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys

doi:10.1002/brb3.3027

	Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys
	Feng, Xiao-Li 1,2,3; Wang, Jiao-Jian 4,5; Wu, Jing 1; Ren, Xiao-Feng 1,6; Zhou, Hui2 ; Li, Si-Yu 2; Zhang, Jie ; Wang, Sheng-Hai 14; Wang, Yun7,8 ; Hu, Zheng-Fei 7,8; Hu, Xin-Tian 1,7,8,9,15; Jiang, Tian-Zi10,11,12,13,15
发表期刊	BRAIN AND BEHAVIOR
ISSN	2162-3279
	2023-07-18
页码	10
通讯作者	Hu, Xin-Tian(xthu@mail.kiz.ac.cn) ; Jiang, Tian-Zi(jiangtz@nlpr.ia.ac.cn)
摘要	ObjectiveAnxious behaviors often occur in individuals who have experienced early adversity. Anxious behaviors can bring many hazards, such as social withdrawal, eating disorders, negative self-efficacy, self-injurious thoughts and behaviors, anxiety disorders, and even depression. Abnormal behavior are is closely related to changes in corresponding circuit functions in the brain. This study investigated the relationship between brain circuits and anxious behaviors in maternal-deprived rhesus monkey animal model, which mimic early adversity in human. MethodsTwenty-five rhesus monkeys (Macaca mulatta) were grouped by two different rearing conditions: 11 normal control and mother-reared (MR) monkeys and 14 maternally deprived and peer-reared (MD) monkeys. After obtaining images of the brain areas with significant differences in maternal separation and normal control macaque function, the relationship between functional junction intensity and stereotypical behaviors was determined by correlation analysis. ResultsThe correlation analysis revealed that stereotypical behaviors were negatively correlated with the coupling between the left lateral amygdala subregion and the left inferior frontal gyrus in both MD and MR macaques. ConclusionThis study suggests that early adversity-induced anxious behaviors are associated with changes in the strength of the amygdala-prefrontal connection. The normalization of the regions involved in the functional connection might reverse the behavioral abnormality. It provides a solid foundation for effective intervention in human early adversity. Significance StatementThis study suggests that early adversity-induced anxious behaviors are associated with changes in the strength of the amygdala-prefrontal connection. The higher the amygdala-prefrontal connection strength, the less stereotyped behaviors exhibited by monkeys experiencing early adversity. Thus, in the future, changing the strength of the amygdala-prefrontal connection may reverse the behavioral abnormalities of individuals who experience early adversity. This study provides a solid foundation for effective intervention in humans' early adversity.
关键词	amygdala-prefrontal connection anxious behaviors brain circuits maternal deprivation rhesus monkeys
DOI	10.1002/brb3.3027
关键词[WOS]	MEDIAL PREFRONTAL CORTEX ; DEVELOPMENTAL EMERGENCE ; ANXIETY ; EMOTION ; FEAR ; EXPRESSION ; STRESS ; TRACTOGRAPHY ; INVOLVEMENT ; ADVERSITY
收录类别	SCI
语种	英语
资助项目	Joint Special Fund Project of Yunnan Provincial Science[2018FE001(-135)] ; Yunnan Province Ten Thousand Talents Program Young Top Talent
项目资助者	Joint Special Fund Project of Yunnan Provincial Science ; Yunnan Province Ten Thousand Talents Program Young Top Talent
WOS研究方向	Behavioral Sciences ; Neurosciences & Neurology
WOS类目	Behavioral Sciences ; Neurosciences
WOS记录号	WOS:001030798900001
出版者	WILEY
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/53811
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Hu, Xin-Tian; Jiang, Tian-Zi
作者单位	1.Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming, Yunnan, Peoples R China 2.Kunming Med Univ, Fac Basic Med Sci, Dept Physiol, Kunming, Yunnan, Peoples R China 3.Kunming Med Univ, Inst Neurosci, Kunming, Yunnan, Peoples R China 4.Kunming Univ Sci & Technol, Inst Primate Translat Med, State Key Lab Primate Biomed Res, Kunming, Peoples R China 5.Yunnan Key Lab Primate Biomed Res, Kunming, Peoples R China 6.Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming, Yunnan, Peoples R China 7.Chinese Acad Sci, Kunming Inst Zool, Natl Resource Ctr Nonhuman Primates, Kunming Primate Res Ctr, Kunming, Yunnan, Peoples R China 8.Chinese Acad Sci, Kunming Inst Zool, Natl Res Facil Phenotyp & Genet Anal Model Anim Pr, Kunming, Yunnan, Peoples R China 9.Chinese Acad Sci, Ctr Excellence Brain Sci, Shanghai, Peoples R China 10.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 11.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 12.Res Ctr Augmented Intelligence, Zhejiang Lab, Hangzhou, Peoples R China 13.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci, Beijing, Peoples R China 14.Kunming Med Univ, Sch Basic Med Sci, Kunming, Yunnan, Peoples R China 15.Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China
通讯作者单位	中国科学院自动化研究所; 模式识别国家重点实验室
推荐引用方式 GB/T 7714	Feng, Xiao-Li,Wang, Jiao-Jian,Wu, Jing,et al. Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys[J]. BRAIN AND BEHAVIOR,2023:10.
APA	Feng, Xiao-Li.,Wang, Jiao-Jian.,Wu, Jing.,Ren, Xiao-Feng.,Zhou, Hui.,...&Jiang, Tian-Zi.(2023).Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys.BRAIN AND BEHAVIOR,10.
MLA	Feng, Xiao-Li,et al."Abnormality of anxious behaviors and functional connectivity between the amygdala and the frontal lobe in maternally deprived monkeys".BRAIN AND BEHAVIOR (2023):10.