2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma

doi:10.1016/j.matdes.2023.112137

	2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma
	Wang, Peifeng 1,3,5; Du, Yang3,4 ; Zhao, Xingyang 1,5; Hu, Yueyang 1,5; Zhou, Tianjun 7; Liang, Xiaolong2 ; Fang, Chihua 1,5; Tian, Jie 3,6
发表期刊	MATERIALS & DESIGN
ISSN	0264-1275
	2023-08-01
卷号	232 页码:11
通讯作者	Liang, Xiaolong(xiaolong_liang@bjmu.edu.cn) ; Fang, Chihua(fangchihua@smu.edu.cn) ; Tian, Jie()
摘要	Hepatocellular carcinoma is a common and highly malignant disease. As a currently designated systemic chemotherapeutic agent for advanced Hepatocellular carcinoma, sorafenib has been confronted with dilemma of drug-resistance caused by tumor hypoxia, which hinders the therapeutic efficacy of the drug. Based on this, amultifunctional mesoporous polydopamine nanoprobe 2Me-SPIO-CY5.5@AAZ-MPDA with a mesoporous frame loaded 2-Methoxyestradiol, Superparamagnetic Iron Oxide Nanoparticles and the near-infrared dye cyanine 5.5, conjugated with hypoxia Hepatocellular carcinoma-specific targeting molecule of sulfonamides acetazolamide, is fabricated for hypoxic region targeting, sorafenib resistance reversion and photothermal therapy of Hepatocellular carcinoma. In addition, the magnetic resonance imaging/fluorescence/photoacoustic tri-modal imaging ability enables the tracing of the nanoprobes and monitoring the treatment procedure in vivo, providing a new methods of imaging-guided Hepatocellular carcinoma synergic treatment which improves the long-term therapeutic effects of sorafenib. (c) 2023 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
关键词	Hepatocellular carcinoma Mesoporous polydopamine Photothermal therapy Sorafenib Hypoxia
DOI	10.1016/j.matdes.2023.112137
关键词[WOS]	TUMOR ; ANGIOGENESIS ; IX
收录类别	SCI
语种	英语
资助项目	National Natural Science Founda- tion of China[81627805] ; National Natural Science Founda- tion of China[12026602] ; National Key Research and Development Program of China[2016YFC0106500]
项目资助者	National Natural Science Founda- tion of China ; National Key Research and Development Program of China
WOS研究方向	Materials Science
WOS类目	Materials Science, Multidisciplinary
WOS记录号	WOS:001038724000001
出版者	ELSEVIER SCI LTD
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/53910
专题	中国科学院分子影像重点实验室
通讯作者	Liang, Xiaolong; Fang, Chihua; Tian, Jie
作者单位	1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Peoples R China 2.Peking Univ Third Hosp, Dept Ultrasound, Beijing 100191, Peoples R China 3.Chinese Acad Sci Inst Automat, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 5.Prov Clin & Engn Ctr Digital Med, Guangzhou 510280, Peoples R China 6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100191, Peoples R China 7.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Thorac Surg, Guangzhou, Peoples R China
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Wang, Peifeng,Du, Yang,Zhao, Xingyang,et al. 2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma[J]. MATERIALS & DESIGN,2023,232:11.
APA	Wang, Peifeng.,Du, Yang.,Zhao, Xingyang.,Hu, Yueyang.,Zhou, Tianjun.,...&Tian, Jie.(2023).2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma.MATERIALS & DESIGN,232,11.
MLA	Wang, Peifeng,et al."2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma".MATERIALS & DESIGN 232(2023):11.