Bioluminescence tomography based on Bayesian approach

	Bioluminescence tomography based on Bayesian approach
	Feng, Jinchao; Jia, Kebin; Tian, Jie; Yan, Guorui; Qin, Chenghu
	2009
会议名称	Progress in Biomedical Optics and Imaging - SPIE
会议录名称	Progress in Biomedical Optics and Imaging - SPIE
会议日期	2009
会议地点	United States San Diego
摘要	As a new mode of molecular imaging, bioluminescence tomography (BLT) will have significant effect on revealing the molecular and cellular information in vivo at the whole-body small animal level because of its high sensitive detection and facile operation. However, BLT is an ill-posed problem, it is necessary to incorporate a priori knowledge into the tomographic algorithm. In this paper, a novel Bayesian reconstruction algorithm for BLT is firstly proposed. In the algorithm, a priori permissible source region strategy is incorporated into the Bayesian network to reduce the ill-posedness of BLT. Then a generalized adaptive Gaussian Markov random field (GAGMRF) prior model for unknown source density estimation is developed to further reduce the ill-posedness of BLT on the basis of adaptive finite element analysis. Finally, the algorithm maximizes the log posterior probability with respect to a noise parameter and the unknown source density, the distribution of bioluminescent source can be reconstructed. In addition, the novel tomography algorithm based adaptive finite element makes the method more appropriate for complex phantom such as real mouse. In the numerical simulation, a heterogeneousphantom is used to evaluate the performance of the proposed algorithm with the Monte Carlo basedsynthetic data. The accurate localization of bioluminescent source and quantitative results show the effectiveness and potential of the tomographic algorithm for BLT.
关键词	Bioluminescence Tomography Bayesian Approach Generalized Adaptive Gaussian Markov Random Field Light Source Reconstruction Diffusion Approximation Adaptive Finite Element Method Monte Carlo Methods
收录类别	EI
文献类型	会议论文
条目标识符	http://ir.ia.ac.cn/handle/173211/5424
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
推荐引用方式 GB/T 7714	Feng, Jinchao,Jia, Kebin,Tian, Jie,et al. Bioluminescence tomography based on Bayesian approach[C],2009.

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