Three-dimensional localization of in vivo bioluminescent source based on multispectral imaging

	Three-dimensional localization of in vivo bioluminescent source based on multispectral imaging
	Feng, Jinchao; Jia, Kebin; Tian, Jie; Yan, Guorui; Zhu, Shouping
	2009
会议名称	Progress in Biomedical Optics and Imaging - SPIE
会议录名称	Progress in Biomedical Optics and Imaging - SPIE
会议日期	2009
会议地点	Lake Buena Vista Florida
摘要	Bioluminescence tomography (BLT) is a novel in vivo technique in small animal studies, which can reveal the molecular and cellular information at the whole-body small animal level. At present, there is an increasing interest in multispectral bioluminescence tomography, since multispectral data acquisition could improve the BLT performance significantly. In view to the ill-posedness of BLT problem, we develop an optimal permissible source region strategy to constrain the possible solution of the source by utilizing spectrum character of bioluminescent source. Then a linear system to link the measured data with the unknown light source variables is established by utilizing the optimal permissible region strategy based on adaptive finite element analysis. Furthermore,singular value decomposition analysis is used for data dimensionality reduction and improving computational efficiency in multispectral case. The reconstructed speed and stability benefit from adaptive finite element, the permissible region strategy and singular value decomposition. In the numerical simulation, the heterogeneous phantom experiment has been used to evaluate the performance of the proposed algorithm with the Monte Carlo based synthetic data. The reconstruction results demonstrate the merits and potential of our methodology for localizing bioluminescent source.
关键词	Multispectral Bioluminescence Tomography Optimal Permissible Source Region Diffusion Approximation Adaptive Finite Element Method Singular Value Decomposition Analysis Monte Carlo Methods
收录类别	EI
文献类型	会议论文
条目标识符	http://ir.ia.ac.cn/handle/173211/5447
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
推荐引用方式 GB/T 7714	Feng, Jinchao,Jia, Kebin,Tian, Jie,et al. Three-dimensional localization of in vivo bioluminescent source based on multispectral imaging[C],2009.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Three-dimensional_lo（487KB）	会议论文		开放获取	CC BY-NC-SA	浏览下载