Knowledge Commons of Institute of Automation,CAS
Altered global signal topography in Alzheimer's disease | |
Chen, Pindong1,2; Zhao, Kun3,4; Zhang, Han3; Wei, Yongbin3; Wang, Pan5; Wang, Dawei6; Song, Chengyuan7; Yang, Hongwei8; Zhang, zengqiang9; Yao, Hongxiang10; Qu, Yida1,2; Kang, Xiaopeng1,2; Fan, Lingzhong1,2; Han, Tong11; Yu, Chunshui12; Zhou, Bo13; Jiang, Tianzi1,2; Zhou, Yuying5; Lu, Jie8; Han, Ying14,15,16; Zhang, Xi10; Liu, Bing17; Liu, Yong1,2,3 | |
发表期刊 | eBioMedicine |
2024-03 | |
页码 | 104455 |
摘要 | Background Alzheimer’s disease (AD) is a neurodegenerative disease associated with widespread disruptions in intrinsic local specialization and global integration in the functional system of the brain. These changes in integration may further disrupt the global signal (GS) distribution, which might represent the local relative contribution to global activity in functional magnetic resonance imaging (fMRI). Methods fMRI scans from a discovery dataset (n = 809) and a validated dataset (n = 542) were used in the analysis. We investigated the alteration of GS topography using the GS correlation (GSCORR) in patients with mild cognitive impairment (MCI) and AD. The association between GS alterations and functional network properties was also investigated based on network theory. The underlying mechanism of GSCORR alterations was elucidated using imaging-transcriptomics. Findings Significantly increased GS topography in the frontal lobe and decreased GS topography in the hippocampus, cingulate gyrus, caudate, and middle temporal gyrus were observed in patients with AD (Padj < 0.05). Notably, topographical GS changes in these regions correlated with cognitive ability (P < 0.05). The changes in GS topography also correlated with the changes in functional network segregation (ρ = 0.5). Moreover, the genes identified based on GS topographical changes were enriched in pathways associated with AD and neurodegenerative diseases. Interpretation Our findings revealed significant changes in GS topography and its molecular basis, confirming the informative role of GS in AD and further contributing to the understanding of the relationship between global and local neuronal activities in patients with AD. |
七大方向——子方向分类 | 脑网络分析 |
国重实验室规划方向分类 | 其他 |
是否有论文关联数据集需要存交 | 否 |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/56686 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
作者单位 | 1.Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, China 2.School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China 3.School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China 4.Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science & Medical Engineering, Beihang University, Beijing, China 5.Department of Neurology, Tianjin Huanhu Hospital Tianjin University, Tianjin, China 6.Department of Radiology, Qilu Hospital of Shandong University, Ji’nan, China 7.g Department of Neurology, Qilu Hospital of Shandong University, Ji’nan, China 8.Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China 9.Branch of Chinese PLA General Hospital, Sanya, China 10.Department of Radiology, the Second Medical Centre, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China 11.Department of Radiology, Tianjin Huanhu Hospital, Tianjin, China 12.Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China 13.Department of Neurology, the Second Medical Centre, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China 14.Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China 15.Beijing Institute of Geriatrics, Beijing, China 16.National Clinical Research Center for Geriatric Disorders, Beijing, China 17.State Key Laboratory of Cognition Neuroscience & Learning, Beijing Normal University, Beijing, China |
第一作者单位 | 中国科学院自动化研究所 |
推荐引用方式 GB/T 7714 | Chen, Pindong,Zhao, Kun,Zhang, Han,et al. Altered global signal topography in Alzheimer's disease[J]. eBioMedicine,2024:104455. |
APA | Chen, Pindong.,Zhao, Kun.,Zhang, Han.,Wei, Yongbin.,Wang, Pan.,...&Liu, Yong.(2024).Altered global signal topography in Alzheimer's disease.eBioMedicine,104455. |
MLA | Chen, Pindong,et al."Altered global signal topography in Alzheimer's disease".eBioMedicine (2024):104455. |
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