Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis

doi:10.1016/j.celrep.2024.113770

	Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis
	Wang, Yaping 1,2; Wang, Yufan2 ; Wang, Haiyan2 ; Ma, Liang 2; Eickhoff, Simon B.5,6; Madsen, Kristoffer Hougaard 1,7,8; Chu, Congying2 ; Fan, Lingzhong1,2,3,4
发表期刊	CELL REPORTS
ISSN	2211-1247
	2024-02-27
卷号	43 期号:2 页码:21
通讯作者	Chu, Congying(chucongying@gmail.com) ; Fan, Lingzhong(lingzhong.fan@ia.ac.cn)
摘要	Cerebellar involvement in both motor and non -motor functions manifests in specific regions of the human cerebellum, revealing the functional heterogeneity within it. One compelling theory places the heterogeneity within the cerebellar functional hierarchy along the sensorimotor-association (SA) axis. Despite extensive neuroimaging studies, evidence for the cerebellar SA axis from different modalities and scales was lacking. Thus, we establish a significant link between the cerebellar SA axis and spatio-molecular profiles. Utilizing the gene set variation analysis, we find the intermediate biological principles the significant genes leveraged to scaffold the cerebellar SA axis. Interestingly, we find these spatio-molecular profiles notably associated with neuropsychiatric dysfunction and recent evolution. Furthermore, cerebello-cerebral interactions at genetic and functional connectivity levels mirror the cerebral cortex and cerebellum's SA axis. These findings can provide a deeper understanding of how the human cerebellar SA axis is shaped and its role in transitioning from sensorimotor to association functions.
DOI	10.1016/j.celrep.2024.113770
关键词[WOS]	PREFRONTAL CORTEX ; GENE ONTOLOGY ; DISEASE ; ATLAS ; NEUROTRANSMITTERS ; ORGANIZATION ; PROJECTIONS ; EXPRESSION ; DISORDERS ; PATTERNS
收录类别	SCI
语种	英语
资助项目	STI2030-Major Projects[2021ZD0200203] ; Natural Science Foundation of China[82072099] ; Natural Science Foundation of China[62250058] ; The 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research[1U54MH091657] ; McDonnell Center for Systems Neuroscience at Washington University
项目资助者	STI2030-Major Projects ; Natural Science Foundation of China ; The 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research ; McDonnell Center for Systems Neuroscience at Washington University
WOS研究方向	Cell Biology
WOS类目	Cell Biology
WOS记录号	WOS:001188121400001
出版者	CELL PRESS
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/56982
专题	脑图谱与类脑智能实验室_脑网络组研究
通讯作者	Chu, Congying; Fan, Lingzhong
作者单位	1.Univ Chinese Acad Sci, Sino Danish Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techno, Beijing 100190, Peoples R China 4.Univ Hlth & Rehabil Sci, Sch Hlth & Life Sci, Qingdao 266000, Peoples R China 5.Res Ctr Julich, Inst Neurosci & Med, INM 7 Brain & Behav, D-52425 Julich, Germany 6.Heinrich Heine Univ Dusseldorf, Inst Syst Neurosci, D-40225 Dusseldorf, Germany 7.Tech Univ Denmark, Dept Appl Math & Comp Sci, DK-2800 Lyngby, Denmark 8.Copenhagen Univ Hosp Amager & Hvidovre, Danish Res Ctr Magnet Resonance, Ctr Funct & Diagnost Imaging & Res, DK-2650 Hvidovre, Denmark
第一作者单位	中国科学院自动化研究所
通讯作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Wang, Yaping,Wang, Yufan,Wang, Haiyan,et al. Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis[J]. CELL REPORTS,2024,43(2):21.
APA	Wang, Yaping.,Wang, Yufan.,Wang, Haiyan.,Ma, Liang.,Eickhoff, Simon B..,...&Fan, Lingzhong.(2024).Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis.CELL REPORTS,43(2),21.
MLA	Wang, Yaping,et al."Spatio-molecular profiles shape the human cerebellar hierarchy along the sensorimotor-association axis".CELL REPORTS 43.2(2024):21.