Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Oral-administered allomelanin-like nanomedicine with multi-enzyme mimesis and favorable gastrointestinal tolerance for amelioration of acute colitis | |
Liu, Yu1,2,3![]() ![]() ![]() | |
发表期刊 | APPLIED MATERIALS TODAY
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ISSN | 2352-9407 |
2024-04-01 | |
卷号 | 37页码:14 |
摘要 | Multifactorial interactions involved pro -inflammatory microenvironment plays a crucial role in ulcerative colitis initiation and progression. Oral nanozymes hold great promise in ameliorating inflammation attributing to their enzyme mimesis -mediated oxidative stress regulation capabilities. However, the development of biocompatible, gastrointestinal well -tolerant, and multi -enzyme mimetic antioxidant nanomedicine is highly desirable but challenging. Here, inspired by natural occurring fungal allomelanin, intrinsically bioactive allomelanin-like nanomedicine (alloMel) were fabricated as a safe and effective formulation for re-educating the intestinal proinflammatory microenvironment in colitis. The as-preapared alloMel possessed satisfactory biocompatibility, hydrogen peroxide -triggered decomposition behavior, broad-spectrum free radical scavenging capacities and specific targeting ability toward the colitis lesions. More importantly, alloMel exhibited favorable tolerance against the harsh gastrointestinal environment, evidenced by structural and property stability assay in simulated gastric fluid and simulated intestinal fluid. Following oral administration into dextran sulfate sodium -induced acute colitis mice, alloMel exhibited superior therapeutic efficacy than that of 2.5 -fold dose of the first -line drug 5-aminosalicylic acid, evidenced by reversed body weight loss, decreased disease activity index, restrained colon length shortening, and mitigatory histopathological abnormalities. Mechanistically, alloMel ameliorated the self-perpetuating pro -inflammatory microenvironment by combined actions including alleviating oxidative stress, reducing the production of pro -inflammatory cytokines, restraining inflammatory cell infiltration, switching macrophage phenotype, and restoring intestinal barrier integrity. Molecularly, alloMel could inhibit the TLR4/MyD88/NF-& kcy;B signaling pathway. In conclusion, the as -reported alloMel with favorable gastrointestinal tolerance and well -elucidated mechanisms represents a potential translational nanomedicine against colitis and oxidative stress -associated other gastrointestinal inflammatory disorders. |
关键词 | Colitis Allomelanin Pro -inflammatory microenvironment Oxidative stress Gastrointestinal tolerance |
DOI | 10.1016/j.apmt.2024.102143 |
关键词[WOS] | NANOPARTICLES ; PATHOGENESIS ; GENETICS ; PROTECT |
收录类别 | SCI |
语种 | 英语 |
资助项目 | National Natural Science Foundation of China[62027901] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81930053] ; National Natural Science Foundation of China[81971662] ; Beijing Natural Science Foundation[JQ22023] ; Beijing Natural Science Foundation[7202105] ; CAS Youth Innovation Promotion Association[Y2022055] |
项目资助者 | National Natural Science Foundation of China ; Beijing Natural Science Foundation ; CAS Youth Innovation Promotion Association |
WOS研究方向 | Materials Science |
WOS类目 | Materials Science, Multidisciplinary |
WOS记录号 | WOS:001209223100001 |
出版者 | ELSEVIER |
七大方向——子方向分类 | 医学影像处理与分析 |
国重实验室规划方向分类 | 其他 |
是否有论文关联数据集需要存交 | 否 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/57039 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Hui, Hui; Tian, Jie |
作者单位 | 1.Beihang Univ, Sch Engn Med, Beijing 100191, Peoples R China 2.Beihang Univ, Sch Biol Sci & Med Engn, Beijing 100191, Peoples R China 3.Beihang Univ, Key Lab Big Data Based Precis Med, Minist Ind & Informat Technol China, Beijing 100191, Peoples R China 4.Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 5.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 7.Natl Key Lab Kidney Dis, Beijing 100853, Peoples R China |
通讯作者单位 | 中国科学院分子影像重点实验室 |
推荐引用方式 GB/T 7714 | Liu, Yu,Gao, Pengli,Jia, Xiaohua,et al. Oral-administered allomelanin-like nanomedicine with multi-enzyme mimesis and favorable gastrointestinal tolerance for amelioration of acute colitis[J]. APPLIED MATERIALS TODAY,2024,37:14. |
APA | Liu, Yu,Gao, Pengli,Jia, Xiaohua,Jiang, Jingying,Hui, Hui,&Tian, Jie.(2024).Oral-administered allomelanin-like nanomedicine with multi-enzyme mimesis and favorable gastrointestinal tolerance for amelioration of acute colitis.APPLIED MATERIALS TODAY,37,14. |
MLA | Liu, Yu,et al."Oral-administered allomelanin-like nanomedicine with multi-enzyme mimesis and favorable gastrointestinal tolerance for amelioration of acute colitis".APPLIED MATERIALS TODAY 37(2024):14. |
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