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精神分裂症失连接假说的静息状态功能磁共振研究
其他题名Dysconnection Hypothesis of Schizophrenia with Resting-State fMRI
周媛
学位类型工学博士
导师蒋田仔
2007-05-24
学位授予单位中国科学院研究生院
学位授予地点中国科学院自动化研究所
学位专业模式识别与智能系统
关键词功能连接 解剖连接 静息状态 精神分裂症 Functional Connectivity Anatomical Connectivity Resting-state Schizophrenia
摘要精神分裂症是一种以功能整合不良为特征的重性精神疾病。脑功能影像学技术的发展为探究这一疾病的病理生理机制提供了新的契机。静息状态脑功能磁共振成像因其无创性、非侵入性、不需复杂的实验设计等特点,吸引了越来越多的精神病学家的注意。本文旨在用静息状态脑功能磁共振成像技术考察精神分裂症功能整合不良的特点,并试图探索精神分裂症功能整合不良的病理生理意义。本文的具体研究内容和取得的创新之处如下: 1.以选择感兴趣区的方式研究了首发精神分裂症患者背外侧前额叶皮层(DLPFC)静息状态功能连接模式。我们发现精神分裂症患者双侧DLPFC与顶叶、后扣带皮层、丘脑和纹状体的功能连接减弱,左侧DLPFC与左侧颞叶中后部及旁边缘区功能连接增强。这种异常的静息状态功能连接模式不仅支持了精神分裂症功能整合不良的观点,而且提示这种功能连接异常可能与静息状态固有脑功能紊乱有关。 2.用计算低频振荡振幅(ALFF)的方法考察了精神分裂症“固有网络”脑区的低频振荡属性的特点。基于文献报道和我们的前期研究,我们首先构建了“固有网络”区域模板,然后逐个体素地比较了精神分裂症患者与正常对照ALFF的差异。研究发现,在精神分裂症患者中与“自我”相关的脑区ALFF降低,而与监测、推断他人精神活动以及与注意相关脑区ALFF增加。这种对自我忽视、而对外在环境改变过于敏感的精神活动的分离,从另一角度支持了精神分裂症功能整合不良。 3.结合fMRI和DTI技术考察了精神分裂症海马静息状态功能连接和解剖连接,试图从连接纤维完整性的角度理解静息状态功能连接的神经生物学意义。我们发现精神分裂症患者双侧海马静息状态功能连接降低,同时穹隆完整性降低,且均以左侧更明显。我们的结果提示,精神分裂症患者穹隆完整性降低至少可以部分解释静息状态海马失连接。此外,我们的研究也提供了一种研究疾病状态静息脑功能连接异常的新思路。
其他摘要Schizophrenia is considered a disorder characterized of improper functional integration. The aims of this dissertation are to investigate the improper functional integration during rest in schizophrenia, and to explore its patophysiological significance. Firstly, for the first time, we investigated the resting-state functional connectivity pattern of the dorsolateral prefrontal cortex (DLPFC) in patients with first-episode schizophrenia (FES) and their matched controls by selecting DLPFC as a region of interest. We found that the bilateral DLPFC showed reduced or enhanced functional connectivities to many regions in FES patients. Our results suggest that the improper functional integrity also exist in resting brain of FES patients, which may be related to the disturbed intrinsic brain activity. Then, we investigated the low frequency fluctuation (LFF) of the regions with the intrinsic brain functional organization pattern by computing the amplitude of LFF (ALFF) in patients with schizophrenia and their matched healthy controls. We found that the regions related to “self” showed decreased ALFF, as well as the regions associated with mentalizing and attention demonstrated increased ALFF in patients with schizophrenia. The split of ignoring self, over-mentalizing and excessively sensitive to the environmental changes provides additional evidence for the improper functional integration observed in schizophrenia. In order to explore the neural correlates of the abnormality in resting-state functional connectivity in schizophrenia, we combined fMRI and diffusion tensor imaging (DTI) to investigate the anatomical and resting-state functional connectivities of hippocampus in patients with paranoid schizophrenia and their matched healthy controls. We found that the bilateral hippocampi showed reduced functional connectivities as well as damaged integrity of the fornix in patients with schizophrenia. Furthermore, the lateralized (left side) vulnerability was found in both resting-state functional connectivity and DTI measure in patients. Our findings therefore suggest that the damage of the integrity of white matter may partially explain the reduced resting-state functional connectivities of the hippocampus in schizophrenia, and provide a multidisciplinary approach to investigate underlying mechanism of the abnormality of resting-state functional connectivity in disease state
馆藏号XWLW1110
其他标识符200418014628017
语种中文
文献类型学位论文
条目标识符http://ir.ia.ac.cn/handle/173211/5969
专题毕业生_博士学位论文
推荐引用方式
GB/T 7714
周媛. 精神分裂症失连接假说的静息状态功能磁共振研究[D]. 中国科学院自动化研究所. 中国科学院研究生院,2007.
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