Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging | |
Hu, Zhenhua1,2 ; Qu, Yawei3; Wang, Kun1,2; Zhang, Xiaojun4; Zha, Jiali3; Song, Tianming1; Bao, Chengpeng1; Liu, Haixiao1; Wang, Zhongliang5; Wang, Jing6; Liu, Zhongyu7; Liu, Haifeng3; Tian, Jie1,2,8
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| Source Publication | NATURE COMMUNICATIONS
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| 2015-06-01 | |
| Volume | 6Issue:-Pages:- |
| Subtype | Article |
| Abstract | Cerenkov luminescence imaging utilizes visible photons emitted from radiopharmaceuticals to achieve in vivo optical molecular-derived signals. Since Cerenkov radiation is weak, non-optimum for tissue penetration and continuous regardless of biological interactions, it is challenging to detect this signal with a diagnostic dose. Therefore, it is challenging to achieve useful activated optical imaging for the acquisition of direct molecular information. Here we introduce a novel imaging strategy, which converts g and Cerenkov radiation from radioisotopes into fluorescence through europium oxide nanoparticles. After a series of imaging studies, we demonstrate that this approach provides strong optical signals with high signal-to-background ratios, an ideal tissue penetration spectrum and activatable imaging ability. In comparison with present imaging techniques, it detects tumour lesions with low radioactive tracer uptake or small tumour lesions more effectively. We believe it will facilitate the development of nuclear and optical molecular imaging for new, highly sensitive imaging applications. |
| Keyword | - |
| WOS Headings | Science & Technology |
| WOS Keyword | CERENKOV LUMINESCENCE TOMOGRAPHY ; F-18-FDG PET ; NANOPHOSPHORS ; RADIOTRACERS ; FEASIBILITY ; GENERATION ; PROBES ; MODEL |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| WOS ID | WOS:000357180700001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/7911 |
| Collection | 中国科学院分子影像重点实验室 |
| Corresponding Author | Liu, Haifeng |
| Affiliation | 1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Gen Hosp Chinese Peoples Armed Police Forces, Dept Gastroenterol, Beijing, Peoples R China 4.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing 100853, Peoples R China 5.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 6.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Peoples R China 7.150 Cent Hosp PLA, Anal Colorectal Surg Inst, Luoyang 471031, Peoples R China 8.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China |
| First Author Affilication | Institute of Automation, Chinese Academy of Sciences; Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Hu, Zhenhua,Qu, Yawei,Wang, Kun,et al. In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging[J]. NATURE COMMUNICATIONS,2015,6(-):-. |
| APA | Hu, Zhenhua.,Qu, Yawei.,Wang, Kun.,Zhang, Xiaojun.,Zha, Jiali.,...&Tian, Jie.(2015).In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging.NATURE COMMUNICATIONS,6(-),-. |
| MLA | Hu, Zhenhua,et al."In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging".NATURE COMMUNICATIONS 6.-(2015):-. |
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| In vivo nanoparticle（2525KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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