EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM

	EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM
	Wang, C.1; Liu, B.2,3 ; Long, H.2,3; Fan, L.2 ; Li, J.2 ; Zhang, X.2 ; Qiu, C.2 ; Yu, C.5; Jiang, T.1,2,3,4,6
发表期刊	NEUROSCIENCE ; NEUROSCIENCE ; NEUROSCIENCE ; NEUROSCIENCE ; NEUROSCIENCE ; NEUROSCIENCE ; NEUROSCIENCE ; NEUROSCIENCE
	2015-07-09 ; 2015-07-09 ; 2015-07-09 ; 2015-07-09 ; 2015-07-09 ; 2015-07-09 ; 2015-07-09 ; 2015-07-09
卷号	298 页码:380-388
文章类型	Article ; Article ; Article ; Article ; Article ; Article ; Article ; Article
摘要	The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
关键词	Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Dopamine Dopamine Dopamine Dopamine Dopamine Dopamine Dopamine Dopamine Frontostriatal System Frontostriatal System Frontostriatal System Frontostriatal System Frontostriatal System Frontostriatal System Frontostriatal System Frontostriatal System Functional Connectivity Functional Connectivity Functional Connectivity Functional Connectivity Functional Connectivity Functional Connectivity Functional Connectivity Functional Connectivity
WOS标题词	Science & Technology ; Science & Technology ; Science & Technology ; Science & Technology ; Science & Technology ; Science & Technology ; Science & Technology ; Science & Technology ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine
关键词[WOS]	O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; BASAL GANGLIA ; BASAL GANGLIA ; BASAL GANGLIA ; BASAL GANGLIA ; BASAL GANGLIA ; BASAL GANGLIA ; BASAL GANGLIA ; BASAL GANGLIA ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; HUMAN BRAIN ; HUMAN BRAIN ; HUMAN BRAIN ; HUMAN BRAIN ; HUMAN BRAIN ; HUMAN BRAIN ; HUMAN BRAIN ; HUMAN BRAIN
收录类别	SCI ; SCI ; SCI ; SCI ; SCI ; SCI ; SCI ; SCI
语种	英语 ; 英语 ; 英语 ; 英语 ; 英语 ; 英语 ; 英语 ; 英语
WOS研究方向	Neurosciences & Neurology ; Neurosciences & Neurology ; Neurosciences & Neurology ; Neurosciences & Neurology ; Neurosciences & Neurology ; Neurosciences & Neurology ; Neurosciences & Neurology ; Neurosciences & Neurology
WOS类目	Neurosciences ; Neurosciences ; Neurosciences ; Neurosciences ; Neurosciences ; Neurosciences ; Neurosciences ; Neurosciences
WOS记录号	WOS:000354783300029 ; WOS:000354783300029 ; WOS:000354783300029 ; WOS:000354783300029 ; WOS:000354783300029 ; WOS:000354783300029 ; WOS:000354783300029 ; WOS:000354783300029
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/7923
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing, Peoples R China 5.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
推荐引用方式 GB/T 7714	Wang, C.,Liu, B.,Long, H.,et al. EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM[J]. NEUROSCIENCE, NEUROSCIENCE, NEUROSCIENCE, NEUROSCIENCE, NEUROSCIENCE, NEUROSCIENCE, NEUROSCIENCE, NEUROSCIENCE,2015, 2015, 2015, 2015, 2015, 2015, 2015, 2015,298, 298, 298, 298, 298, 298, 298, 298:380-388, 380-388, 380-388, 380-388, 380-388, 380-388, 380-388, 380-388.
APA	Wang, C..,Liu, B..,Long, H..,Fan, L..,Li, J..,...&Jiang, T..(2015).EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM.NEUROSCIENCE,298,380-388.
MLA	Wang, C.,et al."EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM".NEUROSCIENCE 298(2015):380-388.

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