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EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM
Wang, C.1; Liu, B.2,3; Long, H.2,3; Fan, L.2; Li, J.2; Zhang, X.2; Qiu, C.2; Yu, C.5; Jiang, T.1,2,3,4,6
2015-07-09
发表期刊NEUROSCIENCE
卷号298页码:380-388
文章类型Article
摘要The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
关键词Brain-derived Neurotrophic Factor (Bdnf) Catechol-o-methyltransferase (Comt) Dopamine Frontostriatal System Functional Connectivity
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]O-METHYLTRANSFERASE COMT ; ACTIVITY-DEPENDENT SECRETION ; ANTERIOR CINGULATE CORTEX ; FUNCTIONAL CONNECTIVITY ; NEUROTROPHIC FACTOR ; VAL66MET POLYMORPHISM ; NUCLEUS-ACCUMBENS ; BASAL GANGLIA ; PREFRONTAL CORTEX ; HUMAN BRAIN
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000354783300029
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/7923
专题脑网络组研究中心
作者单位1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing, Peoples R China
5.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
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Wang, C.,Liu, B.,Long, H.,et al. EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM[J]. NEUROSCIENCE,2015,298:380-388.
APA Wang, C..,Liu, B..,Long, H..,Fan, L..,Li, J..,...&Jiang, T..(2015).EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM.NEUROSCIENCE,298,380-388.
MLA Wang, C.,et al."EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM".NEUROSCIENCE 298(2015):380-388.
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