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EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM; EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM | |
Wang, C.1; Liu, B.2,3; Long, H.2,3; Fan, L.2; Li, J.2; Zhang, X.2; Qiu, C.2; Yu, C.5; Jiang, T.1,2,3,4,6 | |
发表期刊 | NEUROSCIENCE ; NEUROSCIENCE ; NEUROSCIENCE ; NEUROSCIENCE ; NEUROSCIENCE ; NEUROSCIENCE ; NEUROSCIENCE ; NEUROSCIENCE |
2015-07-09 ; 2015-07-09 ; 2015-07-09 ; 2015-07-09 ; 2015-07-09 ; 2015-07-09 ; 2015-07-09 ; 2015-07-09 | |
卷号 | 298页码:380-388 |
文章类型 | Article ; Article ; Article ; Article ; Article ; Article ; Article ; Article |
摘要 | The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.; The frontostriatal system plays a critical role in emotional and cognitive control. Brain-derived neurotrophic factor (BDNF) influences the release of dopamine (DA) in the ventral striatum (VST), while catechol-O-methyltransferase (COMT) impacts DA availability in the prefrontal cortex (PFC). Behavioral studies have already shown a genetic interaction of BDNF Val66Met and COMT Val158Met, but the interaction on the DA-related neural circuit has not been previously studied. Here we show, using functional magnetic resonance imaging in a sample of healthy human subjects, that BDNF and COMT epistatically interacted on the functional connectivity between the bilateral VST and the anterior cingulate cortex. Specifically, BDNF Val66Met impacted the VST-PFC functional connectivity in an inverted U-shaped in COMT Met carriers, while COMT Val homozygotes displayed a U-shaped. These data may be helpful elucidating the mechanism of the interaction between BDNF and COMT on the cognitive functions that are based in the frontostriatal system. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved. |
关键词 | Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Brain-derived Neurotrophic Factor (Bdnf) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Catechol-o-methyltransferase (Comt) Dopamine Dopamine Dopamine Dopamine Dopamine Dopamine Dopamine Dopamine Frontostriatal System Frontostriatal System Frontostriatal System Frontostriatal System Frontostriatal System Frontostriatal System Frontostriatal System Frontostriatal System Functional Connectivity Functional Connectivity Functional Connectivity Functional Connectivity Functional Connectivity Functional Connectivity Functional Connectivity Functional Connectivity |
WOS标题词 | Science & Technology ; Science & Technology ; Science & Technology ; Science & Technology ; Science & Technology ; Science & Technology ; Science & Technology ; Science & Technology ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine |
关键词[WOS] | O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; O-METHYLTRANSFERASE COMT ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ACTIVITY-DEPENDENT SECRETION ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; ANTERIOR CINGULATE CORTEX ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; NEUROTROPHIC FACTOR ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; VAL66MET POLYMORPHISM ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; NUCLEUS-ACCUMBENS ; BASAL GANGLIA ; BASAL GANGLIA ; BASAL GANGLIA ; BASAL GANGLIA ; BASAL GANGLIA ; BASAL GANGLIA ; BASAL GANGLIA ; BASAL GANGLIA ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; PREFRONTAL CORTEX ; HUMAN BRAIN ; HUMAN BRAIN ; HUMAN BRAIN ; HUMAN BRAIN ; HUMAN BRAIN ; HUMAN BRAIN ; HUMAN BRAIN ; HUMAN BRAIN |
收录类别 | SCI ; SCI ; SCI ; SCI ; SCI ; SCI ; SCI ; SCI |
语种 | 英语 ; 英语 ; 英语 ; 英语 ; 英语 ; 英语 ; 英语 ; 英语 |
WOS研究方向 | Neurosciences & Neurology ; Neurosciences & Neurology ; Neurosciences & Neurology ; Neurosciences & Neurology ; Neurosciences & Neurology ; Neurosciences & Neurology ; Neurosciences & Neurology ; Neurosciences & Neurology |
WOS类目 | Neurosciences ; Neurosciences ; Neurosciences ; Neurosciences ; Neurosciences ; Neurosciences ; Neurosciences ; Neurosciences |
WOS记录号 | WOS:000354783300029 ; WOS:000354783300029 ; WOS:000354783300029 ; WOS:000354783300029 ; WOS:000354783300029 ; WOS:000354783300029 ; WOS:000354783300029 ; WOS:000354783300029 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/7923 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
作者单位 | 1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing, Peoples R China 5.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia |
推荐引用方式 GB/T 7714 | Wang, C.,Liu, B.,Long, H.,et al. EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM, EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM[J]. NEUROSCIENCE, NEUROSCIENCE, NEUROSCIENCE, NEUROSCIENCE, NEUROSCIENCE, NEUROSCIENCE, NEUROSCIENCE, NEUROSCIENCE,2015, 2015, 2015, 2015, 2015, 2015, 2015, 2015,298, 298, 298, 298, 298, 298, 298, 298:380-388, 380-388, 380-388, 380-388, 380-388, 380-388, 380-388, 380-388. |
APA | Wang, C..,Liu, B..,Long, H..,Fan, L..,Li, J..,...&Jiang, T..(2015).EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM.NEUROSCIENCE,298,380-388. |
MLA | Wang, C.,et al."EPISTATIC INTERACTION OF BDNF AND COMT ON THE FRONTOSTRIATAL SYSTEM".NEUROSCIENCE 298(2015):380-388. |
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