GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment

	GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment
	Du, Yang1 ; Zhang, Qian1 ; Jing, Lijia 2; Liang, Xiaolong2 ; Chi, Chongwei1 ; Li, Yaqian 1; Yang, Xin1 ; Dai, Zhifei 2; Tian, Jie 1
发表期刊	INTERNATIONAL JOURNAL OF NANOMEDICINE
	2015
卷号	10 页码:3791-3802
文章类型	Article
摘要	Tumor angiogenesis plays a key role in tumor growth and metastasis; thus, targeting tumor-associated angiogenesis is an important goal in cancer therapy. However, the efficient delivery of drugs to tumors remains a key issue in antiangiogenesis therapy. GX1, a peptide identified by phage-display technology, is a novel tumor vasculature endothelium-specific ligand and possesses great potential as a targeted vector and antiangiogenic agent in the diagnosis and treatment of human cancers. Endostar, a novel recombinant human endostatin, has been shown to inhibit tumor angiogenesis. In this study, we developed a theranostic agent composed of GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar (GPENs) and labeled with the near-infrared dye IRDye 800CW to improve colorectal tumor targeting and treatment efficacy in vivo. The in vivo fluorescence molecular imaging data showed that GPENs (IRDye 800CW) more specifically targeted tumors than free IRDye 800CW in colorectal tumor-bearing mice. Moreover, the antitumor efficacy was evaluated by bioluminescence imaging and immunohistology, revealing that GPENs possessed improved antitumor efficacy on subcutaneous colorectal xenografts compared to other treatment groups. Thus, our study showed that GPENs, a novel GX1 peptide guided form of nanoscale Endostar, can be used as a theranostic agent to facilitate more efficient targeted therapy and enable real-time monitoring of therapeutic efficacy in vivo.
关键词	Gx1 Peptide Endostar Colorectal Cancer Angiogenesis Irdye 800cw Molecular Imaging
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	RECOMBINANT HUMAN ENDOSTATIN ; GASTRIC-CANCER ; INTEGRIN ALPHA(V)BETA(3) ; ANTIANGIOGENIC THERAPY ; TUMOR ANGIOGENESIS ; TARGETED THERAPY ; DRUG-DELIVERY ; VASCULATURE ; ACTIVATION ; RESISTANCE
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics ; Pharmacology & Pharmacy
WOS类目	Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS记录号	WOS:000355177500001
引用统计	被引频次：27[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/7927
专题	中国科学院分子影像重点实验室
作者单位	1.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex, Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
第一作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Du, Yang,Zhang, Qian,Jing, Lijia,et al. GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2015,10:3791-3802.
APA	Du, Yang.,Zhang, Qian.,Jing, Lijia.,Liang, Xiaolong.,Chi, Chongwei.,...&Tian, Jie.(2015).GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment.INTERNATIONAL JOURNAL OF NANOMEDICINE,10,3791-3802.
MLA	Du, Yang,et al."GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment".INTERNATIONAL JOURNAL OF NANOMEDICINE 10(2015):3791-3802.

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