Preferential networks of the mediodorsal nucleus and centromedian-parafascicular complex of the thalamus-A DTI tractography study
Eckert, Ulf; Metzger, Coraline D.; Buchmann, Julia E.; Kaufmann, Joern2; Osoba, Annemarie; Li, Meng4; Safron, Adam5; Liao, Wei3; Steiner, Johann; Bogerts, Bernhard; Walter, Martin1
Source PublicationHUMAN BRAIN MAPPING
2012-11-01
Volume33Issue:11Pages:2627-2637
SubtypeArticle
AbstractDistinct thalamic nuclei, like the mediodorsal (MD) nucleus and the centromedian/parafascicular complex (CM/Pf), are embedded in different basal gangliathalamocortical loops, which were shown to integrate cognitive and emotional aspects of human behavior. Despite well described connections on a microscopic scale, derived from tracing studies in animals, little is known about the intrinsic anatomical connections of these nuclei in humans. This lack of knowledge limits not only interpretation of functional imaging studies but also estimation of direct effects of deep brain stimulation which treats diseases as different as epilepsy or major depression. Therefore, non-invasive diffusion tensor imaging (DTI) studies are key to analyzing connectivity patterns and elaborate approaches to close this gap. For our study, we explored the structural connectivity of the MD thalamic nuclei and the CM/Pf complex towards five cortical and six subcortical regions by using a preferential fiber calculation. We found both thalamic nuclei to be preferentially associated to distinct networks: whereas the MD is preferentially connected to prefrontal and limbic cortical regions, the CM is linked to subcortical regions. The anterior insula was the only cortical region associated with the subcortical network of the CM and the cortical network of the MD comprised one subcortical hub, the caudate nucleus, suggesting an integrative role of these two regions. Adding to predescribed anatomical tract tracing connectivities in animal studies, our finding lends support to the existence of similar basal ganglia-thalamocortical circuits in humans and we could show a robust distinction of preferential connectivity for both thalamic nuclei. Hum Brain Mapp, 2012. (c) 2011 Wiley Periodicals, Inc.
KeywordMediodorsal Thalamus Centromedian Thalamus Cortical Networks Subcortical Network Diffusion Tensor Imaging (Dti) Quantitative Tractography Structural Connectivity Human Neuroanatomy Deep Brain Stimulation
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordMEDIAL PREFRONTAL CORTEX ; DEEP BRAIN-STIMULATION ; CM-PF COMPLEX ; BASAL GANGLIA ; CINGULATE CORTEX ; RHESUS-MONKEY ; AFFERENT CONNECTIONS ; THEORETICAL-ANALYSIS ; INTRALAMINAR NUCLEI ; MACAQUE MONKEYS
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000310264500010
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/8011
Collection复杂系统管理与控制国家重点实验室_先进控制与自动化
Affiliation1.Univ Magdeburg, Dept Psychiat, Clin Affect Neuroimaging Lab, D-39120 Magdeburg, Germany
2.Otto von Guericke Univ, Dept Neurol, Magdeburg, Germany
3.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
4.Chinese Acad Sci, Inst Automat, Key Lab Complex Syst & Intelligence Sci, Beijing 100864, Peoples R China
5.Northwestern Univ, Dept Psychol, Evaston, IL USA
Recommended Citation
GB/T 7714
Eckert, Ulf,Metzger, Coraline D.,Buchmann, Julia E.,et al. Preferential networks of the mediodorsal nucleus and centromedian-parafascicular complex of the thalamus-A DTI tractography study[J]. HUMAN BRAIN MAPPING,2012,33(11):2627-2637.
APA Eckert, Ulf.,Metzger, Coraline D..,Buchmann, Julia E..,Kaufmann, Joern.,Osoba, Annemarie.,...&Walter, Martin.(2012).Preferential networks of the mediodorsal nucleus and centromedian-parafascicular complex of the thalamus-A DTI tractography study.HUMAN BRAIN MAPPING,33(11),2627-2637.
MLA Eckert, Ulf,et al."Preferential networks of the mediodorsal nucleus and centromedian-parafascicular complex of the thalamus-A DTI tractography study".HUMAN BRAIN MAPPING 33.11(2012):2627-2637.
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