CASIA OpenIR  > 脑网络组研究中心
DISC1 Ser704Cys impacts thalamic-prefrontal connectivity
Liu, Bing1,2; Fan, Lingzhong1; Cui, Yue1,2; Zhang, Xiaolong1; Hou, Bing1,2; Li, Yonghui3; Qin, Wen4; Wang, Dawei4; Yu, Chunshui4; Jiang, Tianzi1,2,3,5
Source PublicationBRAIN STRUCTURE & FUNCTION
2015
Volume220Issue:1Pages:91-100
SubtypeArticle
AbstractThe Disrupted-in-Schizophrenia 1 (DISC1) gene has been thought as a putative susceptibility gene for various psychiatric disorders, and DISC1 Ser704Cys is associated with variations of brain morphology and function. Moreover, our recent diffusion magnetic resonance imaging (dMRI) study reported that DISC1 Ser704Cys was associated with information transfer efficiency in the brain anatomical network. However, the effects of the DISC1 gene on functional brain connectivity and networks, especially for thalamic-prefrontal circuit, which are disrupted in various psychiatric disorders, are largely unknown. Using a functional connectivity density (FCD) mapping method based on functional magnetic resonance imaging data in a large sample of healthy Han Chinese subjects, we first investigated the association between DISC1 Ser704Cys and short- and long-range FCD hubs. Compared with Ser homozygotes, Cys-allele individuals had increased long-range FCD hubs in the bilateral thalami. The functional and anatomical connectivity of the thalamus to the prefrontal cortex was further analyzed. Significantly increased thalamic-prefrontal functional connectivity and decreased thalamic-prefrontal anatomical connectivity were found in DISC1 Cys-allele carriers. Our findings provide consistent evidence that the DISC1 Ser704Cys polymorphism influences the thalamic-prefrontal circuits in humans and may provide new insights into the neural mechanisms that link DISC1 and the risk for psychiatric disorders.
KeywordDisc1 Functional Connectivity Density Anatomical Connectivity Thalamus Thalamic-prefrontal Circuit
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordNEUROIMAGING FINDINGS ; BIPOLAR DISORDER ; DIFFUSION MRI ; ADULT BRAIN ; SCHIZOPHRENIA ; ASSOCIATION ; DISRUPTED-IN-SCHIZOPHRENIA-1 ; MATTER ; RISK ; POLYMORPHISMS
Indexed BySCI
Language英语
WOS Research AreaAnatomy & Morphology ; Neurosciences & Neurology
WOS SubjectAnatomy & Morphology ; Neurosciences
WOS IDWOS:000348980800009
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/8053
Collection脑网络组研究中心
Affiliation1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
4.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
Recommended Citation
GB/T 7714
Liu, Bing,Fan, Lingzhong,Cui, Yue,et al. DISC1 Ser704Cys impacts thalamic-prefrontal connectivity[J]. BRAIN STRUCTURE & FUNCTION,2015,220(1):91-100.
APA Liu, Bing.,Fan, Lingzhong.,Cui, Yue.,Zhang, Xiaolong.,Hou, Bing.,...&Jiang, Tianzi.(2015).DISC1 Ser704Cys impacts thalamic-prefrontal connectivity.BRAIN STRUCTURE & FUNCTION,220(1),91-100.
MLA Liu, Bing,et al."DISC1 Ser704Cys impacts thalamic-prefrontal connectivity".BRAIN STRUCTURE & FUNCTION 220.1(2015):91-100.
Files in This Item: Download All
File Name/Size DocType Version Access License
Liu-2015-DISC1 Ser70(748KB)期刊论文作者接受稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Liu, Bing]'s Articles
[Fan, Lingzhong]'s Articles
[Cui, Yue]'s Articles
Baidu academic
Similar articles in Baidu academic
[Liu, Bing]'s Articles
[Fan, Lingzhong]'s Articles
[Cui, Yue]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Liu, Bing]'s Articles
[Fan, Lingzhong]'s Articles
[Cui, Yue]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Liu-2015-DISC1 Ser704Cys impa.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.