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DISC1 Ser704Cys impacts thalamic-prefrontal connectivity
Liu, Bing1,2; Fan, Lingzhong1; Cui, Yue1,2; Zhang, Xiaolong1; Hou, Bing1,2; Li, Yonghui3; Qin, Wen4; Wang, Dawei4; Yu, Chunshui4; Jiang, Tianzi1,2,3,5
2015
发表期刊BRAIN STRUCTURE & FUNCTION
卷号220期号:1页码:91-100
文章类型Article
摘要The Disrupted-in-Schizophrenia 1 (DISC1) gene has been thought as a putative susceptibility gene for various psychiatric disorders, and DISC1 Ser704Cys is associated with variations of brain morphology and function. Moreover, our recent diffusion magnetic resonance imaging (dMRI) study reported that DISC1 Ser704Cys was associated with information transfer efficiency in the brain anatomical network. However, the effects of the DISC1 gene on functional brain connectivity and networks, especially for thalamic-prefrontal circuit, which are disrupted in various psychiatric disorders, are largely unknown. Using a functional connectivity density (FCD) mapping method based on functional magnetic resonance imaging data in a large sample of healthy Han Chinese subjects, we first investigated the association between DISC1 Ser704Cys and short- and long-range FCD hubs. Compared with Ser homozygotes, Cys-allele individuals had increased long-range FCD hubs in the bilateral thalami. The functional and anatomical connectivity of the thalamus to the prefrontal cortex was further analyzed. Significantly increased thalamic-prefrontal functional connectivity and decreased thalamic-prefrontal anatomical connectivity were found in DISC1 Cys-allele carriers. Our findings provide consistent evidence that the DISC1 Ser704Cys polymorphism influences the thalamic-prefrontal circuits in humans and may provide new insights into the neural mechanisms that link DISC1 and the risk for psychiatric disorders.
关键词Disc1 Functional Connectivity Density Anatomical Connectivity Thalamus Thalamic-prefrontal Circuit
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]NEUROIMAGING FINDINGS ; BIPOLAR DISORDER ; DIFFUSION MRI ; ADULT BRAIN ; SCHIZOPHRENIA ; ASSOCIATION ; DISRUPTED-IN-SCHIZOPHRENIA-1 ; MATTER ; RISK ; POLYMORPHISMS
收录类别SCI
语种英语
WOS研究方向Anatomy & Morphology ; Neurosciences & Neurology
WOS类目Anatomy & Morphology ; Neurosciences
WOS记录号WOS:000348980800009
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/8053
专题脑网络组研究中心
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
4.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
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Liu, Bing,Fan, Lingzhong,Cui, Yue,et al. DISC1 Ser704Cys impacts thalamic-prefrontal connectivity[J]. BRAIN STRUCTURE & FUNCTION,2015,220(1):91-100.
APA Liu, Bing.,Fan, Lingzhong.,Cui, Yue.,Zhang, Xiaolong.,Hou, Bing.,...&Jiang, Tianzi.(2015).DISC1 Ser704Cys impacts thalamic-prefrontal connectivity.BRAIN STRUCTURE & FUNCTION,220(1),91-100.
MLA Liu, Bing,et al."DISC1 Ser704Cys impacts thalamic-prefrontal connectivity".BRAIN STRUCTURE & FUNCTION 220.1(2015):91-100.
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