| DISC1 Ser704Cys impacts thalamic-prefrontal connectivity | |
Liu, Bing1,2 ; Fan, Lingzhong1; Cui, Yue1,2; Zhang, Xiaolong1; Hou, Bing1,2; Li, Yonghui3; Qin, Wen4; Wang, Dawei4; Yu, Chunshui4; Jiang, Tianzi1,2,3,5
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| 发表期刊 | BRAIN STRUCTURE & FUNCTION
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| 2015 | |
| 卷号 | 220期号:1页码:91-100 |
| 文章类型 | Article |
| 摘要 | The Disrupted-in-Schizophrenia 1 (DISC1) gene has been thought as a putative susceptibility gene for various psychiatric disorders, and DISC1 Ser704Cys is associated with variations of brain morphology and function. Moreover, our recent diffusion magnetic resonance imaging (dMRI) study reported that DISC1 Ser704Cys was associated with information transfer efficiency in the brain anatomical network. However, the effects of the DISC1 gene on functional brain connectivity and networks, especially for thalamic-prefrontal circuit, which are disrupted in various psychiatric disorders, are largely unknown. Using a functional connectivity density (FCD) mapping method based on functional magnetic resonance imaging data in a large sample of healthy Han Chinese subjects, we first investigated the association between DISC1 Ser704Cys and short- and long-range FCD hubs. Compared with Ser homozygotes, Cys-allele individuals had increased long-range FCD hubs in the bilateral thalami. The functional and anatomical connectivity of the thalamus to the prefrontal cortex was further analyzed. Significantly increased thalamic-prefrontal functional connectivity and decreased thalamic-prefrontal anatomical connectivity were found in DISC1 Cys-allele carriers. Our findings provide consistent evidence that the DISC1 Ser704Cys polymorphism influences the thalamic-prefrontal circuits in humans and may provide new insights into the neural mechanisms that link DISC1 and the risk for psychiatric disorders. |
| 关键词 | Disc1 Functional Connectivity Density Anatomical Connectivity Thalamus Thalamic-prefrontal Circuit |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 关键词[WOS] | NEUROIMAGING FINDINGS ; BIPOLAR DISORDER ; DIFFUSION MRI ; ADULT BRAIN ; SCHIZOPHRENIA ; ASSOCIATION ; DISRUPTED-IN-SCHIZOPHRENIA-1 ; MATTER ; RISK ; POLYMORPHISMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Anatomy & Morphology ; Neurosciences & Neurology |
| WOS类目 | Anatomy & Morphology ; Neurosciences |
| WOS记录号 | WOS:000348980800009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/8053 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 4.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China |
| 第一作者单位 | 中国科学院自动化研究所; 模式识别国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Liu, Bing,Fan, Lingzhong,Cui, Yue,et al. DISC1 Ser704Cys impacts thalamic-prefrontal connectivity[J]. BRAIN STRUCTURE & FUNCTION,2015,220(1):91-100. |
| APA | Liu, Bing.,Fan, Lingzhong.,Cui, Yue.,Zhang, Xiaolong.,Hou, Bing.,...&Jiang, Tianzi.(2015).DISC1 Ser704Cys impacts thalamic-prefrontal connectivity.BRAIN STRUCTURE & FUNCTION,220(1),91-100. |
| MLA | Liu, Bing,et al."DISC1 Ser704Cys impacts thalamic-prefrontal connectivity".BRAIN STRUCTURE & FUNCTION 220.1(2015):91-100. |
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| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Liu-2015-DISC1 Ser70（748KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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