| Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals | |
Zhang, Xiaolong1,2; Yu, Jin-Tai3,4; Li, Jin1,2 ; Wang, Chao5; Tan, Lan3; Liu, Bing1,2; Jiang, Tianzi1,2,5,6
| |
| 发表期刊 | NEUROPSYCHOPHARMACOLOGY
 |
| 2015-06-01 | |
| 卷号 | 40期号:7页码:1794-1803 |
| 文章类型 | Article |
| 摘要 | Alzheimer's disease (AD) is the most common form of dementia and exhibits a considerable level of heritability. The bridging integrator 1 (BIN1) gene has recently been identified in several large genome-wide association studies (GWAS) as the second most important risk locus for AD following apolipoprotein E (APOE). However, how and when the established genetic risk locus BIN1 rs744373 confers risk to late-onset AD has yet to be determined. Here using an imaging genetic strategy in large-sample Chinese subjects, we show that healthy homozygous carriers of the rs744373 risk allele exhibit worse high-load working memory (WM) performance, larger hippocampal volume and lower functional connectivity between the bilateral hippocampus and the right dorsolateral prefrontal cortex (DLPFC), mirroring clinical evidence of disturbed memory and connectivity in patients. Our findings demonstrate that rs744373 itself or a variation in linkage disequilibrium may provide a neurogenetic mechanism for BIN1 while further validating the possibility of combining genetic and neuroimaging strategies to monitor individuals at risk for AD. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 关键词[WOS] | MILD COGNITIVE IMPAIRMENT ; VOXEL-BASED MORPHOMETRY ; MEDIAL TEMPORAL-LOBE ; ALZHEIMERS-DISEASE ; PREFRONTAL CORTEX ; EPSILON-4 ALLELE ; BRAIN ACTIVATION ; APOLIPOPROTEIN-E ; COMMON VARIANTS ; RISK VARIANT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry |
| WOS类目 | Neurosciences ; Pharmacology & Pharmacy ; Psychiatry |
| WOS记录号 | WOS:000354321600025 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/8075 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Qingdao Univ, Qingdao Municipal Hosp, Sch Med, Dept Neurol, Qingdao 266071, Peoples R China 4.Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA 5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia |
| 第一作者单位 | 中国科学院自动化研究所; 模式识别国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaolong,Yu, Jin-Tai,Li, Jin,et al. Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals[J]. NEUROPSYCHOPHARMACOLOGY,2015,40(7):1794-1803. |
| APA | Zhang, Xiaolong.,Yu, Jin-Tai.,Li, Jin.,Wang, Chao.,Tan, Lan.,...&Jiang, Tianzi.(2015).Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals.NEUROPSYCHOPHARMACOLOGY,40(7),1794-1803. |
| MLA | Zhang, Xiaolong,et al."Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals".NEUROPSYCHOPHARMACOLOGY 40.7(2015):1794-1803. |
| 条目包含的文件 | 下载所有文件 | |||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| Zhang_NPP2015.pdf（1863KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论