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An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae
Wu, Chuan-hong1; Chen, Jian-xin2; Lu, Pang3; Chen, Chang1; Li, Shao-jing1
2013-07-01
发表期刊ACTA PHARMACOLOGICA SINICA
卷号34期号:11页码:116-117
文章类型Meeting Abstract
摘要Recently, the pharmaceutical industry has shifted to pursuing combination therapies that comprise more than one active ingredient. Interestingly, combination therapies have been used for more than 2500 years in traditional Chinese medicine (TCM). Understanding optimal proportions and synergistic mechanisms of multi-component drugs are critical for developing novel strategies to combat complex diseases. A new multi-objective optimization algorithm based on least angle regression-partial least squares was proposed to construct the predictive model to evaluate the synergistic effect of the three components of a novel combination drug Yi-qi-jie-du formula (YJ), which came from clinical TCM prescription for the treatment of encephalopathy. Optimal proportion of the three components, ginsenosides (G), berberine (B) and jasminoidin (J) was determined via particle swarm optimum. Furthermore, the combination mechanisms were interpreted using PLS VIP and principal components analysis. The results showed that YJ had optimal proportion 3(G): 2(B): 0.5(J), and it yielded synergy in the treatment of rats impaired by middle cerebral artery occlusion induced focal cerebral ischemia. YJ with optimal proportion had good pharmacological effects on acute ischemic stroke. The mechanisms study demonstrated that the combination of G, B and J could exhibit the strongest synergistic effect. J might play an indispensable role in the formula, especially when combined with B for the acute stage of stroke. All these data in this study suggested that in the treatment of acute ischemic stroke, besides restoring blood supply and protecting easily damaged cells in the area of the ischemic penumbra as early as possible, we should pay more attention to the removal of the toxic metabolites at the same time. Mathematical system modeling may be an essential tool for the analysis of the complex pharmacological effects of multi-component drug. The powerful mathematical analysis method could greatly improve the efficiency in finding new combination drug from TCM.
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
关键词[WOS]PARTIAL LEAST-SQUARES ; PERMEABILITY TRANSITION PORE ; BILOBA EXTRACT EGB ; KINASE-C-EPSILON ; ARTERY OCCLUSION ; IN-VITRO ; GINSENOSIDE-RE ; MITOCHONDRIAL DYSFUNCTION ; PREVENTS APOPTOSIS ; REPERFUSION INJURY
收录类别SCI
语种英语
WOS研究方向Chemistry ; Pharmacology & Pharmacy
WOS类目Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS记录号WOS:000322051500514
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/8936
专题综合信息系统研究中心
作者单位1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China
2.Beijing Univ Chinese Med, Beijing 100029, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
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GB/T 7714
Wu, Chuan-hong,Chen, Jian-xin,Lu, Pang,et al. An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae[J]. ACTA PHARMACOLOGICA SINICA,2013,34(11):116-117.
APA Wu, Chuan-hong,Chen, Jian-xin,Lu, Pang,Chen, Chang,&Li, Shao-jing.(2013).An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae.ACTA PHARMACOLOGICA SINICA,34(11),116-117.
MLA Wu, Chuan-hong,et al."An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae".ACTA PHARMACOLOGICA SINICA 34.11(2013):116-117.
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