An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae

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	An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae
	Wu, Chuan-hong 1; Chen, Jian-xin 2; Lu, Pang 3; Chen, Chang 1; Li, Shao-jing 1
发表期刊	ACTA PHARMACOLOGICA SINICA
	2013-07-01
卷号	34 期号:11 页码:116-117
文章类型	Meeting Abstract
摘要	Recently, the pharmaceutical industry has shifted to pursuing combination therapies that comprise more than one active ingredient. Interestingly, combination therapies have been used for more than 2500 years in traditional Chinese medicine (TCM). Understanding optimal proportions and synergistic mechanisms of multi-component drugs are critical for developing novel strategies to combat complex diseases. A new multi-objective optimization algorithm based on least angle regression-partial least squares was proposed to construct the predictive model to evaluate the synergistic effect of the three components of a novel combination drug Yi-qi-jie-du formula (YJ), which came from clinical TCM prescription for the treatment of encephalopathy. Optimal proportion of the three components, ginsenosides (G), berberine (B) and jasminoidin (J) was determined via particle swarm optimum. Furthermore, the combination mechanisms were interpreted using PLS VIP and principal components analysis. The results showed that YJ had optimal proportion 3(G): 2(B): 0.5(J), and it yielded synergy in the treatment of rats impaired by middle cerebral artery occlusion induced focal cerebral ischemia. YJ with optimal proportion had good pharmacological effects on acute ischemic stroke. The mechanisms study demonstrated that the combination of G, B and J could exhibit the strongest synergistic effect. J might play an indispensable role in the formula, especially when combined with B for the acute stage of stroke. All these data in this study suggested that in the treatment of acute ischemic stroke, besides restoring blood supply and protecting easily damaged cells in the area of the ischemic penumbra as early as possible, we should pay more attention to the removal of the toxic metabolites at the same time. Mathematical system modeling may be an essential tool for the analysis of the complex pharmacological effects of multi-component drug. The powerful mathematical analysis method could greatly improve the efficiency in finding new combination drug from TCM.
WOS标题词	Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
关键词[WOS]	PARTIAL LEAST-SQUARES ; PERMEABILITY TRANSITION PORE ; BILOBA EXTRACT EGB ; KINASE-C-EPSILON ; ARTERY OCCLUSION ; IN-VITRO ; GINSENOSIDE-RE ; MITOCHONDRIAL DYSFUNCTION ; PREVENTS APOPTOSIS ; REPERFUSION INJURY
收录类别	SCI
语种	英语
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS类目	Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS记录号	WOS:000322051500514
引用统计
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/8936
专题	综合信息系统研究中心
作者单位	1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 2.Beijing Univ Chinese Med, Beijing 100029, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Wu, Chuan-hong,Chen, Jian-xin,Lu, Pang,et al. An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae[J]. ACTA PHARMACOLOGICA SINICA,2013,34(11):116-117.
APA	Wu, Chuan-hong,Chen, Jian-xin,Lu, Pang,Chen, Chang,&Li, Shao-jing.(2013).An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae.ACTA PHARMACOLOGICA SINICA,34(11),116-117.
MLA	Wu, Chuan-hong,et al."An effective solution to discover synergistic drugs for anti-cerebral ischemia from traditional Chinese medicinal formulae".ACTA PHARMACOLOGICA SINICA 34.11(2013):116-117.