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Characterizing the dynamic connectivity between genes by variable parameter regression and Kalman filtering based on temporal gene expression data
Cui, QH; Liu, B; Jiang, TX; Ma, SD
2005-04-15
发表期刊BIOINFORMATICS
卷号21期号:8页码:1538-1541
文章类型Article
摘要Motivation: One popular method for analyzing functional connectivity between genes is to cluster genes with similar expression profiles. The most popular metrics measuring the similarity (or dissimilarity) among genes include Pearson's correlation, linear regression coefficient and Euclidean distance. As these metrics only give some constant values, they can only depict a stationary connectivity between genes. However, the functional connectivity between genes usually changes with time. Here, we introduce a novel insight for characterizing the relationship between genes and find out a proper mathematical model, variable parameter regression and Kalman filtering to model it.
WOS标题词Science & Technology ; Life Sciences & Biomedicine ; Technology ; Physical Sciences
关键词[WOS]CELL-CYCLE
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Computer Science ; Mathematical & Computational Biology ; Mathematics
WOS类目Biochemical Research Methods ; Biotechnology & Applied Microbiology ; Computer Science, Interdisciplinary Applications ; Mathematical & Computational Biology ; Statistics & Probability
WOS记录号WOS:000228401800037
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9138
专题09年以前成果
作者单位Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714
Cui, QH,Liu, B,Jiang, TX,et al. Characterizing the dynamic connectivity between genes by variable parameter regression and Kalman filtering based on temporal gene expression data[J]. BIOINFORMATICS,2005,21(8):1538-1541.
APA Cui, QH,Liu, B,Jiang, TX,&Ma, SD.(2005).Characterizing the dynamic connectivity between genes by variable parameter regression and Kalman filtering based on temporal gene expression data.BIOINFORMATICS,21(8),1538-1541.
MLA Cui, QH,et al."Characterizing the dynamic connectivity between genes by variable parameter regression and Kalman filtering based on temporal gene expression data".BIOINFORMATICS 21.8(2005):1538-1541.
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