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Characterizing the dynamic connectivity between genes by variable parameter regression and Kalman filtering based on temporal gene expression data | |
Cui, QH; Liu, B![]() ![]() | |
发表期刊 | BIOINFORMATICS
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2005-04-15 | |
卷号 | 21期号:8页码:1538-1541 |
文章类型 | Article |
摘要 | Motivation: One popular method for analyzing functional connectivity between genes is to cluster genes with similar expression profiles. The most popular metrics measuring the similarity (or dissimilarity) among genes include Pearson's correlation, linear regression coefficient and Euclidean distance. As these metrics only give some constant values, they can only depict a stationary connectivity between genes. However, the functional connectivity between genes usually changes with time. Here, we introduce a novel insight for characterizing the relationship between genes and find out a proper mathematical model, variable parameter regression and Kalman filtering to model it. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology ; Physical Sciences |
关键词[WOS] | CELL-CYCLE |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Computer Science ; Mathematical & Computational Biology ; Mathematics |
WOS类目 | Biochemical Research Methods ; Biotechnology & Applied Microbiology ; Computer Science, Interdisciplinary Applications ; Mathematical & Computational Biology ; Statistics & Probability |
WOS记录号 | WOS:000228401800037 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/9138 |
专题 | 09年以前成果 |
作者单位 | Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China |
推荐引用方式 GB/T 7714 | Cui, QH,Liu, B,Jiang, TX,et al. Characterizing the dynamic connectivity between genes by variable parameter regression and Kalman filtering based on temporal gene expression data[J]. BIOINFORMATICS,2005,21(8):1538-1541. |
APA | Cui, QH,Liu, B,Jiang, TX,&Ma, SD.(2005).Characterizing the dynamic connectivity between genes by variable parameter regression and Kalman filtering based on temporal gene expression data.BIOINFORMATICS,21(8),1538-1541. |
MLA | Cui, QH,et al."Characterizing the dynamic connectivity between genes by variable parameter regression and Kalman filtering based on temporal gene expression data".BIOINFORMATICS 21.8(2005):1538-1541. |
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