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Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging
Liang, M; Zhou, Y; Jiang, TZ; Liu, ZN; Tian, LX; Liu, HH; Hao, YH
Source PublicationNEUROREPORT
2006-02-06
Volume17Issue:2Pages:209-213
SubtypeArticle
AbstractUsing resting-state functional magnetic resonance imaging, we examined the functional connectivity throughout the entire brain in schizophrenia. The abnormalities in functional connectivity were identified by comparing the correlation coefficients of each pair of 116 brain regions between 15 patients and 15 controls. Then, the global distribution of the abnormal functional connectivities was examined. Experimental results indicated, in general, a decreased functional connectivity in schizophrenia during rest, and such abnormalities were widely distributed throughout the entire brain rather than restricted to a few specific brain regions. The results provide a quantitative support for the hypothesis that schizophrenia may arise from the disrupted functional integration of widespread brain areas.
KeywordFunctional Connectivity Functional Magnetic Resonance Imaging Resting State Schizophrenia
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordHUMAN BRAIN ; 1ST-EPISODE SCHIZOPHRENIA ; MOTOR CORTEX ; CONNECTIVITY ; IMAGES ; FMRI ; MRI ; FLUCTUATIONS ; SINGLE
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000235349800020
Citation statistics
Cited Times:270[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9232
Collection09年以前成果
Affiliation1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
2.Cent S Univ, Xiangya Hosp 2, Inst Mental Hlth, Changsha 410083, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Liang, M,Zhou, Y,Jiang, TZ,et al. Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging[J]. NEUROREPORT,2006,17(2):209-213.
APA Liang, M.,Zhou, Y.,Jiang, TZ.,Liu, ZN.,Tian, LX.,...&Hao, YH.(2006).Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging.NEUROREPORT,17(2),209-213.
MLA Liang, M,et al."Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging".NEUROREPORT 17.2(2006):209-213.
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