Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI

CASIA OpenIR > 09年以前成果

	Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI
	Wang, Kun ; Jiang, Tianzi; Liang, Meng ; Wang, Liang ; Tian, Lixia ; Zhang, Xinqing ; Li, Kuncheng ; Liu, Zhening ; Larsen, R ; Nielsen, M ; Sporring, J
发表期刊	MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2
	2006
卷号	4191 页码:340-347
文章类型	Article
摘要	In this work, we proposed a discriminative model of Alzhei-mer's disease (AD) on the basis of multivariate pattern classification and functional magnetic resonance imaging (fMRI). This model used the correlation/anti-correlation coefficients of two intrinsically anti-correlated networks in resting brains, which have been suggested by two recent studies, as the feature of classification. Pseudo-Fisher Linear Discriminative Analysis (pFLDA) was then performed on the feature space and a linear classifier was generated. Using leave-one-out (LOO) cross validation, our results showed a correct classification rate of 83%. We also compared the proposed model with another one based on the whole brain functional connectivity. Our proposed model outperformed the other one significantly, and this implied that the two intrinsically anti-correlated networks may be a more susceptible part of the whole brain network in the early stage of AD.
WOS标题词	Science & Technology ; Technology ; Life Sciences & Biomedicine
关键词[WOS]	FUNCTIONAL CONNECTIVITY ; BRAIN-FUNCTION ; FLUCTUATIONS ; RESOURCES ; ATTENTION ; SINGLE ; MEMORY
收录类别	ISTP ; SCI
语种	英语
WOS研究方向	Computer Science ; Engineering ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Computer Science, Interdisciplinary Applications ; Computer Science, Theory & Methods ; Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000241556700042
引用统计	被引频次：74[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/9353
专题	09年以前成果
作者单位	1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China 2.Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 3.CEnt S Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha 410011, Peoples R China
推荐引用方式 GB/T 7714	Wang, Kun,Jiang, Tianzi,Liang, Meng,et al. Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI[J]. MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2,2006,4191:340-347.
APA	Wang, Kun.,Jiang, Tianzi.,Liang, Meng.,Wang, Liang.,Tian, Lixia.,...&Sporring, J.(2006).Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI.MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2,4191,340-347.
MLA	Wang, Kun,et al."Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI".MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2 4191(2006):340-347.