CASIA OpenIR  > 09年以前成果
Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI
Wang, Kun; Jiang, Tianzi; Liang, Meng; Wang, Liang; Tian, Lixia; Zhang, Xinqing; Li, Kuncheng; Liu, Zhening; Larsen, R; Nielsen, M; Sporring, J
Source PublicationMEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2
2006
Volume4191Pages:340-347
SubtypeArticle
AbstractIn this work, we proposed a discriminative model of Alzhei-mer's disease (AD) on the basis of multivariate pattern classification and functional magnetic resonance imaging (fMRI). This model used the correlation/anti-correlation coefficients of two intrinsically anti-correlated networks in resting brains, which have been suggested by two recent studies, as the feature of classification. Pseudo-Fisher Linear Discriminative Analysis (pFLDA) was then performed on the feature space and a linear classifier was generated. Using leave-one-out (LOO) cross validation, our results showed a correct classification rate of 83%. We also compared the proposed model with another one based on the whole brain functional connectivity. Our proposed model outperformed the other one significantly, and this implied that the two intrinsically anti-correlated networks may be a more susceptible part of the whole brain network in the early stage of AD.
WOS HeadingsScience & Technology ; Technology ; Life Sciences & Biomedicine
WOS KeywordFUNCTIONAL CONNECTIVITY ; BRAIN-FUNCTION ; FLUCTUATIONS ; RESOURCES ; ATTENTION ; SINGLE ; MEMORY
Indexed ByISTP ; SCI
Language英语
WOS Research AreaComputer Science ; Engineering ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectComputer Science, Interdisciplinary Applications ; Computer Science, Theory & Methods ; Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000241556700042
Citation statistics
Cited Times:57[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9353
Collection09年以前成果
Affiliation1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
2.Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China
3.CEnt S Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha 410011, Peoples R China
Recommended Citation
GB/T 7714
Wang, Kun,Jiang, Tianzi,Liang, Meng,et al. Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI[J]. MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2,2006,4191:340-347.
APA Wang, Kun.,Jiang, Tianzi.,Liang, Meng.,Wang, Liang.,Tian, Lixia.,...&Sporring, J.(2006).Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI.MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2,4191,340-347.
MLA Wang, Kun,et al."Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI".MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2 4191(2006):340-347.
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