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Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI
Wang, Kun; Jiang, Tianzi; Liang, Meng; Wang, Liang; Tian, Lixia; Zhang, Xinqing; Li, Kuncheng; Liu, Zhening; Larsen, R; Nielsen, M; Sporring, J
2006
发表期刊MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2
卷号4191页码:340-347
文章类型Article
摘要In this work, we proposed a discriminative model of Alzhei-mer's disease (AD) on the basis of multivariate pattern classification and functional magnetic resonance imaging (fMRI). This model used the correlation/anti-correlation coefficients of two intrinsically anti-correlated networks in resting brains, which have been suggested by two recent studies, as the feature of classification. Pseudo-Fisher Linear Discriminative Analysis (pFLDA) was then performed on the feature space and a linear classifier was generated. Using leave-one-out (LOO) cross validation, our results showed a correct classification rate of 83%. We also compared the proposed model with another one based on the whole brain functional connectivity. Our proposed model outperformed the other one significantly, and this implied that the two intrinsically anti-correlated networks may be a more susceptible part of the whole brain network in the early stage of AD.
WOS标题词Science & Technology ; Technology ; Life Sciences & Biomedicine
关键词[WOS]FUNCTIONAL CONNECTIVITY ; BRAIN-FUNCTION ; FLUCTUATIONS ; RESOURCES ; ATTENTION ; SINGLE ; MEMORY
收录类别ISTP ; SCI
语种英语
WOS研究方向Computer Science ; Engineering ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Computer Science, Interdisciplinary Applications ; Computer Science, Theory & Methods ; Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000241556700042
引用统计
被引频次:54[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9353
专题09年以前成果
作者单位1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
2.Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China
3.CEnt S Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha 410011, Peoples R China
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Wang, Kun,Jiang, Tianzi,Liang, Meng,et al. Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI[J]. MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2,2006,4191:340-347.
APA Wang, Kun.,Jiang, Tianzi.,Liang, Meng.,Wang, Liang.,Tian, Lixia.,...&Sporring, J.(2006).Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI.MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2,4191,340-347.
MLA Wang, Kun,et al."Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI".MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2 4191(2006):340-347.
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