Knowledge Commons of Institute of Automation,CAS
Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI | |
Wang, Kun; Jiang, Tianzi![]() | |
发表期刊 | MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2
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2006 | |
卷号 | 4191页码:340-347 |
文章类型 | Article |
摘要 | In this work, we proposed a discriminative model of Alzhei-mer's disease (AD) on the basis of multivariate pattern classification and functional magnetic resonance imaging (fMRI). This model used the correlation/anti-correlation coefficients of two intrinsically anti-correlated networks in resting brains, which have been suggested by two recent studies, as the feature of classification. Pseudo-Fisher Linear Discriminative Analysis (pFLDA) was then performed on the feature space and a linear classifier was generated. Using leave-one-out (LOO) cross validation, our results showed a correct classification rate of 83%. We also compared the proposed model with another one based on the whole brain functional connectivity. Our proposed model outperformed the other one significantly, and this implied that the two intrinsically anti-correlated networks may be a more susceptible part of the whole brain network in the early stage of AD. |
WOS标题词 | Science & Technology ; Technology ; Life Sciences & Biomedicine |
关键词[WOS] | FUNCTIONAL CONNECTIVITY ; BRAIN-FUNCTION ; FLUCTUATIONS ; RESOURCES ; ATTENTION ; SINGLE ; MEMORY |
收录类别 | ISTP ; SCI |
语种 | 英语 |
WOS研究方向 | Computer Science ; Engineering ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Computer Science, Interdisciplinary Applications ; Computer Science, Theory & Methods ; Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000241556700042 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/9353 |
专题 | 09年以前成果 |
作者单位 | 1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China 2.Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 3.CEnt S Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha 410011, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Kun,Jiang, Tianzi,Liang, Meng,et al. Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI[J]. MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2,2006,4191:340-347. |
APA | Wang, Kun.,Jiang, Tianzi.,Liang, Meng.,Wang, Liang.,Tian, Lixia.,...&Sporring, J.(2006).Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI.MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2,4191,340-347. |
MLA | Wang, Kun,et al."Discriminative analysis of early Alzheimer's disease based on two intrinsically anti-correlated networks with resting-state fMRI".MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2006, PT 2 4191(2006):340-347. |
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