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Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI | |
Zhou, Yuan; Liang, Meng; Jiang, Tianzi; Tian, Lixia; Liu, Yong; Liu, Zhening; Liu, Haihong; Kuang, Fan | |
发表期刊 | NEUROSCIENCE LETTERS |
2007-05-07 | |
卷号 | 417期号:3页码:297-302 |
文章类型 | Article |
摘要 | The known regional abnormality of the dorsolateral prefrontal cortex (DLPFC) and its role in various neural circuits in schizophrenia has given prominence to its importance in studies on the dysconnection associated with schizophrenia. Abnormal functional connectivities of the DLPFC have been found during various goal-directed tasks; however, the occurrence of the abnormality during rest in patients with schizophrenia has rarely been reported. In the present study, we selected bilateral Brodmann's area 46 as region of interest and analyzed the differences in the DLPFC functional connectivity pattern between 17 patients with first-episode schizophrenia (FES) and 17 matched controls using resting-state fmRI. We found that the bilateral DLPFC showed reduced functional connectivities to the parietal lobe, posterior cingulate cortex, thalamus and striatum in FES patients. We also found enhanced functional connectivity between the left DLPFC and the left mid-posterior temporal lobe and the paralimbic regions in FES patients. Our results suggest that functional dysconnectivity associated with the DLPFC exists in schizophrenia during rest. This may be partially related to disturbance in the intrinsic brain activity. (c) 2007 Elsevier Ireland Ltd. All rights reserved. |
关键词 | Schizophrenia Fmri Dorsolateral Prefrontal Cortex Connectivity Resting State |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
关键词[WOS] | LOW-FREQUENCY ; DEFAULT MODE ; HUMAN BRAIN ; CONNECTIVITY ; DISCONNECTIVITY ; FLUCTUATIONS ; HYPOTHESIS ; HYPOFRONTALITY ; NETWORK |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neurosciences |
WOS记录号 | WOS:000246666500016 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/9408 |
专题 | 09年以前成果 |
作者单位 | 1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China 2.Cent S Univ, Xiangya Hosp 2, Inst Mental Hlth, Changsha 410011, Hunan, Peoples R China |
推荐引用方式 GB/T 7714 | Zhou, Yuan,Liang, Meng,Jiang, Tianzi,et al. Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI[J]. NEUROSCIENCE LETTERS,2007,417(3):297-302. |
APA | Zhou, Yuan.,Liang, Meng.,Jiang, Tianzi.,Tian, Lixia.,Liu, Yong.,...&Kuang, Fan.(2007).Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI.NEUROSCIENCE LETTERS,417(3),297-302. |
MLA | Zhou, Yuan,et al."Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI".NEUROSCIENCE LETTERS 417.3(2007):297-302. |
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