Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study

CASIA OpenIR > 09年以前成果

	Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study
	Wang, Kun ; Liang, Meng ; Wang, Liang ; Tian, Lixia ; Zhang, Xinqing ; Li, Kuncheng ; Jiang, Tianzi
发表期刊	HUMAN BRAIN MAPPING
	2007-10-01
卷号	28 期号:10 页码:967-978
文章类型	Article
摘要	Previous studies have led to the proposal that patients with Alzheimer's disease (AD) may have disturbed functional connectivity between different brain regions. Furthermore, recent resting-state functional magnetic resonance imaging (fMRI) studies have also shown that low-frequency (< 0.08 Hz) fluctuations (LFF) of the blood oxygenation level-dependent signals were abnormal in several brain areas of AD patients. However, few studies have investigated disturbed LFF connectivity in AD patients. By using resting-state fMRI, this study sought to investigate the abnormal functional connectivities throughout the entire brain of early AD patients, and analyze the global distribution of these abnormalities. For this purpose, the authors divided the whole brain into 116 regions and identified abnormal connectivities by comparing the correlation coefficients of each pair. Compared with healthy controls, AD patients had decreased positive correlations between the prefrontal and parietal lobes, but increased positive correlations within the prefrontal lobe, parietal lobe, and occipital lobe. The AD patients also had decreased negative correlations (closer to zero) between two intrinsically anti-correlated networks that had previously been found in the resting brain. By using resting-state FVRI, our results supported previous studies that have reported an anterior-posterior disconnection phenomenon and increased within-lobe functional connectivity in AD patients. In addition, the results also suggest that AD may disturb the correlation/anti-correlation effect in the two intrinsically anti-correlated networks.
关键词	Alzheimer's Disease Fmri Resting-state Low-frequency Blood Oxygenation Level-dependent Fluctuations Functional Connectivity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	MILD COGNITIVE IMPAIRMENT ; STAGE ALZHEIMER-DISEASE ; GLUCOSE METABOLIC RATES ; DEFAULT-MODE ; HUMAN BRAIN ; NETWORK ANALYSIS ; LOW-FREQUENCY ; DEMENTIA ; MRI ; TASK
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000249990700006
引用统计	被引频次：572[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/9457
专题	09年以前成果
作者单位	1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China 2.Univ Med Sci, Xuanwu Hosp Capital, Dept Radiol, Beijing 100053, Peoples R China 3.Univ Med Sci, Xuanwu Hosp Capital, Dept Neurol, Beijing 100053, Peoples R China
推荐引用方式 GB/T 7714	Wang, Kun,Liang, Meng,Wang, Liang,et al. Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study[J]. HUMAN BRAIN MAPPING,2007,28(10):967-978.
APA	Wang, Kun.,Liang, Meng.,Wang, Liang.,Tian, Lixia.,Zhang, Xinqing.,...&Jiang, Tianzi.(2007).Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study.HUMAN BRAIN MAPPING,28(10),967-978.
MLA	Wang, Kun,et al."Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study".HUMAN BRAIN MAPPING 28.10(2007):967-978.