Knowledge Commons of Institute of Automation,CAS
Functional disintegration in paranoid schizophrenia using resting-state fMRI | |
Zhou, Yuan2; Liang, Meng2; Tian, Lixia2; Wang, Kun2; Hao, Yihui1; Liu, Haihong1; Liu, Zhening1; Jiang, Tianzi2 | |
发表期刊 | SCHIZOPHRENIA RESEARCH |
2007-12-01 | |
卷号 | 97期号:1-3页码:194-205 |
文章类型 | Article |
摘要 | Functional disintegration has been observed in schizophrenia during task performance. We sought to investigate functional disintegration during rest because an intrinsic functional brain organization, including, both '' task-negative '' (i.e., '' default mode '') and '' task-positive '' networks, has been suggested to play an important role in integrating ongoing information processing. Additionally, the brain regions that are involved in the intrinsic organization are believed to be abnormal in schizophrenia. Patients with paranoid schizophrenia (N= 18) and healthy volunteers (N= 18) underwent a resting-state fMRI scan. Functional connectivity analysis was used to identify the connectivity between each pair of brain regions within this intrinsic organization, and differences were examined in patients versus healthy volunteers. Compared to healthy volunteers, patients showed significant differences in connectivity within networks and between networks, most notably in the connectivities associated with the bilateral dorsal medial prefrontal cortex, the lateral parietal region, the inferior temporal gyros of the '' task-negative '' network and with the right dorsolateral prefrontal cortex and the right dorsal premotor cortex of the '' task-positive '' network. These results suggested that the interregional functional connectivities in the intrinsic organization are altered in patients with paranoid schizophrenia. These abnormalities could be the source of abnormalities in the coordination of and competition between information processing activities in the resting brain of paranoid patients. (c) 2007 Elsevier B.V. All rights reserved. |
关键词 | Schizophrenia Fmri Resting-state Functional Connectivity |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
关键词[WOS] | ALTERED EFFECTIVE CONNECTIVITY ; DEFAULT MODE ; HUMAN BRAIN ; AUDITORY HALLUCINATIONS ; DATA SETS ; CORTEX ; HYPOTHESIS ; FLUCTUATIONS ; ATTENTION ; SINGLE |
收录类别 | SCI ; SSCI |
语种 | 英语 |
WOS研究方向 | Psychiatry |
WOS类目 | Psychiatry |
WOS记录号 | WOS:000251742000022 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/9495 |
专题 | 09年以前成果 |
作者单位 | 1.Cent S Univ, Xiangya Hosp 2, Inst Mental Hlth, Changsha 410011, Hunan, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China |
第一作者单位 | 模式识别国家重点实验室 |
推荐引用方式 GB/T 7714 | Zhou, Yuan,Liang, Meng,Tian, Lixia,et al. Functional disintegration in paranoid schizophrenia using resting-state fMRI[J]. SCHIZOPHRENIA RESEARCH,2007,97(1-3):194-205. |
APA | Zhou, Yuan.,Liang, Meng.,Tian, Lixia.,Wang, Kun.,Hao, Yihui.,...&Jiang, Tianzi.(2007).Functional disintegration in paranoid schizophrenia using resting-state fMRI.SCHIZOPHRENIA RESEARCH,97(1-3),194-205. |
MLA | Zhou, Yuan,et al."Functional disintegration in paranoid schizophrenia using resting-state fMRI".SCHIZOPHRENIA RESEARCH 97.1-3(2007):194-205. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论