CASIA OpenIR  > 09年以前成果
Functional disintegration in paranoid schizophrenia using resting-state fMRI
Zhou, Yuan2; Liang, Meng2; Tian, Lixia2; Wang, Kun2; Hao, Yihui1; Liu, Haihong1; Liu, Zhening1; Jiang, Tianzi2
Source PublicationSCHIZOPHRENIA RESEARCH
2007-12-01
Volume97Issue:1-3Pages:194-205
SubtypeArticle
AbstractFunctional disintegration has been observed in schizophrenia during task performance. We sought to investigate functional disintegration during rest because an intrinsic functional brain organization, including, both '' task-negative '' (i.e., '' default mode '') and '' task-positive '' networks, has been suggested to play an important role in integrating ongoing information processing. Additionally, the brain regions that are involved in the intrinsic organization are believed to be abnormal in schizophrenia. Patients with paranoid schizophrenia (N= 18) and healthy volunteers (N= 18) underwent a resting-state fMRI scan. Functional connectivity analysis was used to identify the connectivity between each pair of brain regions within this intrinsic organization, and differences were examined in patients versus healthy volunteers. Compared to healthy volunteers, patients showed significant differences in connectivity within networks and between networks, most notably in the connectivities associated with the bilateral dorsal medial prefrontal cortex, the lateral parietal region, the inferior temporal gyros of the '' task-negative '' network and with the right dorsolateral prefrontal cortex and the right dorsal premotor cortex of the '' task-positive '' network. These results suggested that the interregional functional connectivities in the intrinsic organization are altered in patients with paranoid schizophrenia. These abnormalities could be the source of abnormalities in the coordination of and competition between information processing activities in the resting brain of paranoid patients. (c) 2007 Elsevier B.V. All rights reserved.
KeywordSchizophrenia Fmri Resting-state Functional Connectivity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordALTERED EFFECTIVE CONNECTIVITY ; DEFAULT MODE ; HUMAN BRAIN ; AUDITORY HALLUCINATIONS ; DATA SETS ; CORTEX ; HYPOTHESIS ; FLUCTUATIONS ; ATTENTION ; SINGLE
Indexed BySCI ; SSCI
Language英语
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000251742000022
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9495
Collection09年以前成果
Affiliation1.Cent S Univ, Xiangya Hosp 2, Inst Mental Hlth, Changsha 410011, Hunan, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Yuan,Liang, Meng,Tian, Lixia,et al. Functional disintegration in paranoid schizophrenia using resting-state fMRI[J]. SCHIZOPHRENIA RESEARCH,2007,97(1-3):194-205.
APA Zhou, Yuan.,Liang, Meng.,Tian, Lixia.,Wang, Kun.,Hao, Yihui.,...&Jiang, Tianzi.(2007).Functional disintegration in paranoid schizophrenia using resting-state fMRI.SCHIZOPHRENIA RESEARCH,97(1-3),194-205.
MLA Zhou, Yuan,et al."Functional disintegration in paranoid schizophrenia using resting-state fMRI".SCHIZOPHRENIA RESEARCH 97.1-3(2007):194-205.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhou, Yuan]'s Articles
[Liang, Meng]'s Articles
[Tian, Lixia]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhou, Yuan]'s Articles
[Liang, Meng]'s Articles
[Tian, Lixia]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhou, Yuan]'s Articles
[Liang, Meng]'s Articles
[Tian, Lixia]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.