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Functional disintegration in paranoid schizophrenia using resting-state fMRI
Zhou, Yuan2; Liang, Meng2; Tian, Lixia2; Wang, Kun2; Hao, Yihui1; Liu, Haihong1; Liu, Zhening1; Jiang, Tianzi2
2007-12-01
发表期刊SCHIZOPHRENIA RESEARCH
卷号97期号:1-3页码:194-205
文章类型Article
摘要Functional disintegration has been observed in schizophrenia during task performance. We sought to investigate functional disintegration during rest because an intrinsic functional brain organization, including, both '' task-negative '' (i.e., '' default mode '') and '' task-positive '' networks, has been suggested to play an important role in integrating ongoing information processing. Additionally, the brain regions that are involved in the intrinsic organization are believed to be abnormal in schizophrenia. Patients with paranoid schizophrenia (N= 18) and healthy volunteers (N= 18) underwent a resting-state fMRI scan. Functional connectivity analysis was used to identify the connectivity between each pair of brain regions within this intrinsic organization, and differences were examined in patients versus healthy volunteers. Compared to healthy volunteers, patients showed significant differences in connectivity within networks and between networks, most notably in the connectivities associated with the bilateral dorsal medial prefrontal cortex, the lateral parietal region, the inferior temporal gyros of the '' task-negative '' network and with the right dorsolateral prefrontal cortex and the right dorsal premotor cortex of the '' task-positive '' network. These results suggested that the interregional functional connectivities in the intrinsic organization are altered in patients with paranoid schizophrenia. These abnormalities could be the source of abnormalities in the coordination of and competition between information processing activities in the resting brain of paranoid patients. (c) 2007 Elsevier B.V. All rights reserved.
关键词Schizophrenia Fmri Resting-state Functional Connectivity
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ALTERED EFFECTIVE CONNECTIVITY ; DEFAULT MODE ; HUMAN BRAIN ; AUDITORY HALLUCINATIONS ; DATA SETS ; CORTEX ; HYPOTHESIS ; FLUCTUATIONS ; ATTENTION ; SINGLE
收录类别SCI ; SSCI
语种英语
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000251742000022
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被引频次:246[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9495
专题09年以前成果
作者单位1.Cent S Univ, Xiangya Hosp 2, Inst Mental Hlth, Changsha 410011, Hunan, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
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Zhou, Yuan,Liang, Meng,Tian, Lixia,et al. Functional disintegration in paranoid schizophrenia using resting-state fMRI[J]. SCHIZOPHRENIA RESEARCH,2007,97(1-3):194-205.
APA Zhou, Yuan.,Liang, Meng.,Tian, Lixia.,Wang, Kun.,Hao, Yihui.,...&Jiang, Tianzi.(2007).Functional disintegration in paranoid schizophrenia using resting-state fMRI.SCHIZOPHRENIA RESEARCH,97(1-3),194-205.
MLA Zhou, Yuan,et al."Functional disintegration in paranoid schizophrenia using resting-state fMRI".SCHIZOPHRENIA RESEARCH 97.1-3(2007):194-205.
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