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Modularity in the genetic disease-phenotype network
Jiang, Xingpeng; Liu, Bing; Jiang, Jiefeng; Zhao, Huizhi; Fan, Ming; Zhang, Jing; Fan, Zhenjie; Jiang, Tianzi
Source PublicationFEBS LETTERS
2008-07-23
Volume582Issue:17Pages:2549-2554
SubtypeArticle
AbstractSimilar disease phenotypes are engendered as a result of the modular nature of gene networks; thus we hypothesized that all human genetic disease phenotypes appear in similar modular styles. Network representations of phenotypes make it possible to explore this hypothesis. We investigated the modularity of a network of genetic disease phenotypes. We computationally extracted phenotype modules and found that the modularity is well correlated with a physiological classi. cation of human diseases. We also found correlations between the modularity and functional genomics as well as its connection to drug- target associations. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
KeywordModularity Phenotype/genotype Relation Classification Systems Biology
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordHUMAN PHENOME ; DISORDERS ; KNOWLEDGEBASE ; INTERACTOME ; PREDICTION ; DATABASE ; PROJECT ; TISSUES
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS SubjectBiochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS IDWOS:000258112000014
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9703
Collection09年以前成果
AffiliationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Jiang, Xingpeng,Liu, Bing,Jiang, Jiefeng,et al. Modularity in the genetic disease-phenotype network[J]. FEBS LETTERS,2008,582(17):2549-2554.
APA Jiang, Xingpeng.,Liu, Bing.,Jiang, Jiefeng.,Zhao, Huizhi.,Fan, Ming.,...&Jiang, Tianzi.(2008).Modularity in the genetic disease-phenotype network.FEBS LETTERS,582(17),2549-2554.
MLA Jiang, Xingpeng,et al."Modularity in the genetic disease-phenotype network".FEBS LETTERS 582.17(2008):2549-2554.
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