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Modularity in the genetic disease-phenotype network
Jiang, Xingpeng; Liu, Bing; Jiang, Jiefeng; Zhao, Huizhi; Fan, Ming; Zhang, Jing; Fan, Zhenjie; Jiang, Tianzi
2008-07-23
发表期刊FEBS LETTERS
卷号582期号:17页码:2549-2554
文章类型Article
摘要Similar disease phenotypes are engendered as a result of the modular nature of gene networks; thus we hypothesized that all human genetic disease phenotypes appear in similar modular styles. Network representations of phenotypes make it possible to explore this hypothesis. We investigated the modularity of a network of genetic disease phenotypes. We computationally extracted phenotype modules and found that the modularity is well correlated with a physiological classi. cation of human diseases. We also found correlations between the modularity and functional genomics as well as its connection to drug- target associations. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
关键词Modularity Phenotype/genotype Relation Classification Systems Biology
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]HUMAN PHENOME ; DISORDERS ; KNOWLEDGEBASE ; INTERACTOME ; PREDICTION ; DATABASE ; PROJECT ; TISSUES
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS类目Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
WOS记录号WOS:000258112000014
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9703
专题09年以前成果
作者单位Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
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GB/T 7714
Jiang, Xingpeng,Liu, Bing,Jiang, Jiefeng,et al. Modularity in the genetic disease-phenotype network[J]. FEBS LETTERS,2008,582(17):2549-2554.
APA Jiang, Xingpeng.,Liu, Bing.,Jiang, Jiefeng.,Zhao, Huizhi.,Fan, Ming.,...&Jiang, Tianzi.(2008).Modularity in the genetic disease-phenotype network.FEBS LETTERS,582(17),2549-2554.
MLA Jiang, Xingpeng,et al."Modularity in the genetic disease-phenotype network".FEBS LETTERS 582.17(2008):2549-2554.
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