A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics

doi:10.1002/smll.201501266

	A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics
	Jiang, Qiao 1; Shi, Yuefeng 2; Zhang, Qian3 ; Li, Na1 ; Zhan, Pengfei 1; Song, Linlin 1; Dai, Luru 1; Tian, Jie 3; Du, Yang3 ; Cheng, Zhen 4; Ding, Baoquan 1
发表期刊	SMALL
	2015-10-14
卷号	11 期号:38 页码:5134-5141
文章类型	Article
摘要	A self-assembled DNA origami (DO)-gold nanorod (GNR) complex, which is a dual-functional nanotheranostics constructed by decorating GNRs onto the surface of DNA origami, is demonstrated. After 24 h incubation of two structured DO-GNR complexes with human MCF7 breast cancer cells, significant enhancement of cell uptake is achieved compared to bare GNRs by two-photon luminescence imaging. Particularly, the triangle shaped DO-GNR complex exhibits optimal cellular accumulation. Compared to GNRs, improved photothermolysis against tumor cells is accomplished for the triangle DO-GNR complex by two-photon laser or NIR laser irradiation. Moreover, the DO-GNR complex exhibits enhanced antitumor efficacy compared with bare GNRs in nude mice bearing breast tumor xenografts. The results demonstrate that the DO-GNR complex can achieve optimal two-photon cell imaging and photothermal effect, suggesting a promising candidate for cancer diagnosis and therapy both in vitro and in vivo.
关键词	None
WOS标题词	Science & Technology ; Physical Sciences ; Technology
DOI	10.1002/smll.201501266
关键词[WOS]	PHOTOTHERMAL THERAPY PPTT ; DRUG-DELIVERY ; NANOPARTICLES ; NANOSTRUCTURES ; NANOTECHNOLOGY ; CARCINOMA ; PLATFORM ; SHAPES ; CELLS ; MICE
收录类别	SCI
语种	英语
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS记录号	WOS:000362819700017
引用统计	被引频次：91[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/10334
专题	中国科学院分子影像重点实验室
作者单位	1.Natl Ctr NanoSci & Technol, CAS Key Lab Nanosyst & Hierarchial Fabricat, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Genet & Dev Biol, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 4.Stanford Univ, Dept Radiol, Lucas Ctr, Stanford, CA 94305 USA
推荐引用方式 GB/T 7714	Jiang, Qiao,Shi, Yuefeng,Zhang, Qian,et al. A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics[J]. SMALL,2015,11(38):5134-5141.
APA	Jiang, Qiao.,Shi, Yuefeng.,Zhang, Qian.,Li, Na.,Zhan, Pengfei.,...&Ding, Baoquan.(2015).A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics.SMALL,11(38),5134-5141.
MLA	Jiang, Qiao,et al."A Self-Assembled DNA Origami-Gold Nanorod Complex for Cancer Theranostics".SMALL 11.38(2015):5134-5141.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
Jiang_et_al-2015-Sma（2191KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载