Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer

doi:10.1039/c6nr00056h

	Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer
	Sun, Mengmeng 1; Liu, Fei1 ; Zhu, Yukun 2; Wang, Wansheng 1; Hu, Jin 1; Liu, Jing 1; Dai, Zhifei 3,4; Wang, Kun2 ; Wei, Yen 5; Bai, Jing 1; Gao, Weiping 1
发表期刊	NANOSCALE
	2016
卷号	8 期号:8 页码:4452-4457
文章类型	Article
摘要	The challenge in photothermal therapy (PTT) is to develop bio-compatible photothermal transducers that can absorb and convert near-infrared (NIR) light into heat with high efficiency. Herein, we report salt-induced aggregation of gold nanoparticles (GNPs) in biological media to form highly efficient and biocompatible NIR photothermal transducers for PTT and photothermal/photoacoustic (PT/PA) imaging of cancer. The GNP depots in situ formed by salt-induced aggregation of GNPs show strong NIR absorption induced by plasmonic coupling between adjacent GNPs and very high photothermal conversion efficiency (52%), enabling photothermal destruction of tumor cells. More interestingly, GNPs in situ aggregate in tumors to form GNP depots, enabling simultaneous PT/PA imaging and PTT of the tumors. These findings may provide a simple and effective way to develop a new class of intelligent and biocompatible NIR photothermal transducers with high efficiency for PT/PA imaging and PTT.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
DOI	10.1039/c6nr00056h
关键词[WOS]	PH-INDUCED AGGREGATION ; IN-VIVO ; ORGANIC NANOPARTICLES ; ABLATION ; CELLS ; AGENT ; NANOVESICLES ; NANOSHEETS ; RESONANCE ; SELENIDE
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(21274043 ; National Basic Research Program of China (973)(2011CB707701) ; 21534006 ; 81227901)
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号	WOS:000371117900004
引用统计	被引频次：110[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/11360
专题	中国科学院分子影像重点实验室
作者单位	1.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Peking Univ, Coll Engn, Beijing 100871, Peoples R China 4.Peking Univ, Hosp 3, Beijing 100871, Peoples R China 5.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
推荐引用方式 GB/T 7714	Sun, Mengmeng,Liu, Fei,Zhu, Yukun,et al. Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer[J]. NANOSCALE,2016,8(8):4452-4457.
APA	Sun, Mengmeng.,Liu, Fei.,Zhu, Yukun.,Wang, Wansheng.,Hu, Jin.,...&Gao, Weiping.(2016).Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer.NANOSCALE,8(8),4452-4457.
MLA	Sun, Mengmeng,et al."Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer".NANOSCALE 8.8(2016):4452-4457.

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