CASIA OpenIR  > 中国科学院分子影像重点实验室
Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer
Sun, Mengmeng1; Liu, Fei1; Zhu, Yukun2; Wang, Wansheng1; Hu, Jin1; Liu, Jing1; Dai, Zhifei3,4; Wang, Kun2; Wei, Yen5; Bai, Jing1; Gao, Weiping1
Source PublicationNANOSCALE
2016
Volume8Issue:8Pages:4452-4457
SubtypeArticle
AbstractThe challenge in photothermal therapy (PTT) is to develop bio-compatible photothermal transducers that can absorb and convert near-infrared (NIR) light into heat with high efficiency. Herein, we report salt-induced aggregation of gold nanoparticles (GNPs) in biological media to form highly efficient and biocompatible NIR photothermal transducers for PTT and photothermal/photoacoustic (PT/PA) imaging of cancer. The GNP depots in situ formed by salt-induced aggregation of GNPs show strong NIR absorption induced by plasmonic coupling between adjacent GNPs and very high photothermal conversion efficiency (52%), enabling photothermal destruction of tumor cells. More interestingly, GNPs in situ aggregate in tumors to form GNP depots, enabling simultaneous PT/PA imaging and PTT of the tumors. These findings may provide a simple and effective way to develop a new class of intelligent and biocompatible NIR photothermal transducers with high efficiency for PT/PA imaging and PTT.
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1039/c6nr00056h
WOS KeywordPH-INDUCED AGGREGATION ; IN-VIVO ; ORGANIC NANOPARTICLES ; ABLATION ; CELLS ; AGENT ; NANOVESICLES ; NANOSHEETS ; RESONANCE ; SELENIDE
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(21274043 ; National Basic Research Program of China (973)(2011CB707701) ; 21534006 ; 81227901)
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000371117900004
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/11360
Collection中国科学院分子影像重点实验室
Affiliation1.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
5.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Sun, Mengmeng,Liu, Fei,Zhu, Yukun,et al. Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer[J]. NANOSCALE,2016,8(8):4452-4457.
APA Sun, Mengmeng.,Liu, Fei.,Zhu, Yukun.,Wang, Wansheng.,Hu, Jin.,...&Gao, Weiping.(2016).Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer.NANOSCALE,8(8),4452-4457.
MLA Sun, Mengmeng,et al."Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer".NANOSCALE 8.8(2016):4452-4457.
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