CASIA OpenIR  > 中国科学院分子影像重点实验室
Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer
Sun, Mengmeng1; Liu, Fei1; Zhu, Yukun2; Wang, Wansheng1; Hu, Jin1; Liu, Jing1; Dai, Zhifei3,4; Wang, Kun2; Wei, Yen5; Bai, Jing1; Gao, Weiping1
2016
发表期刊NANOSCALE
卷号8期号:8页码:4452-4457
文章类型Article
摘要The challenge in photothermal therapy (PTT) is to develop bio-compatible photothermal transducers that can absorb and convert near-infrared (NIR) light into heat with high efficiency. Herein, we report salt-induced aggregation of gold nanoparticles (GNPs) in biological media to form highly efficient and biocompatible NIR photothermal transducers for PTT and photothermal/photoacoustic (PT/PA) imaging of cancer. The GNP depots in situ formed by salt-induced aggregation of GNPs show strong NIR absorption induced by plasmonic coupling between adjacent GNPs and very high photothermal conversion efficiency (52%), enabling photothermal destruction of tumor cells. More interestingly, GNPs in situ aggregate in tumors to form GNP depots, enabling simultaneous PT/PA imaging and PTT of the tumors. These findings may provide a simple and effective way to develop a new class of intelligent and biocompatible NIR photothermal transducers with high efficiency for PT/PA imaging and PTT.
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1039/c6nr00056h
关键词[WOS]PH-INDUCED AGGREGATION ; IN-VIVO ; ORGANIC NANOPARTICLES ; ABLATION ; CELLS ; AGENT ; NANOVESICLES ; NANOSHEETS ; RESONANCE ; SELENIDE
收录类别SCI
语种英语
项目资助者National Natural Science Foundation of China(21274043 ; National Basic Research Program of China (973)(2011CB707701) ; 21534006 ; 81227901)
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000371117900004
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/11360
专题中国科学院分子影像重点实验室
作者单位1.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
5.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
推荐引用方式
GB/T 7714
Sun, Mengmeng,Liu, Fei,Zhu, Yukun,et al. Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer[J]. NANOSCALE,2016,8(8):4452-4457.
APA Sun, Mengmeng.,Liu, Fei.,Zhu, Yukun.,Wang, Wansheng.,Hu, Jin.,...&Gao, Weiping.(2016).Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer.NANOSCALE,8(8),4452-4457.
MLA Sun, Mengmeng,et al."Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer".NANOSCALE 8.8(2016):4452-4457.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
sun2016.pdf(1870KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Sun, Mengmeng]的文章
[Liu, Fei]的文章
[Zhu, Yukun]的文章
百度学术
百度学术中相似的文章
[Sun, Mengmeng]的文章
[Liu, Fei]的文章
[Zhu, Yukun]的文章
必应学术
必应学术中相似的文章
[Sun, Mengmeng]的文章
[Liu, Fei]的文章
[Zhu, Yukun]的文章
相关权益政策
暂无数据
收藏/分享
文件名: sun2016.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。