Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas | |
Fan, Xing1,2; Wang, Yinyan1,2; Liu, Yong3; Liu, Xing1; Zhang, Chuanbao2; Wang, Lei1; Li, Shaowu4; Ma, Jun5; Jiang, Tao1,2,6 | |
发表期刊 | JOURNAL OF NEURO-ONCOLOGY |
2016-07-01 | |
卷号 | 128期号:3页码:455-462 |
文章类型 | Article |
摘要 | Human telomerase reverse transcriptase (TERT) promoter mutations are important genetic alterations in many kinds of human malignancies, including glioma. The current study aimed to investigate the anatomical specificity of TERT promoter mutations in glioblastomas (GBMs). Clinical information and preoperative magnetic resonance images of 203 patients with GBMs were reviewed. TERT promoter mutation status was assessed by Sanger sequencing in all cases. Tumor lesions were manually segmented and then registered to a standard brain atlas. Then the specific brain regions associated with TERT promoter mutation status were subsequently identified by voxel-based regression analysis. TERT promoter mutations were detected in 94 (46.3 %) of the 203 patients. Voxel-based statistical analysis demonstrated that GBMs with TERT promoter mutations were much more likely to locate in the right temporal lobe, while those with wild-type TERT promoters were more likely to occur in the anterior region of the right lateral ventricle. No significant difference was found in the lesion volumes of the T2-identified tumor or in the contrast enhancement areas between the two groups. The current study demonstrated the anatomic specificity of TERT promoter mutation status in GBM. These findings may provide new insight into the molecular classification of GBM and further our understanding of the associations between tumor-specific molecular alterations and tumor location. |
关键词 | Glioblastoma Telomerase Reverse Transcriptase Anatomical Specificity Voxel-based Mapping |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1007/s11060-016-2132-y |
关键词[WOS] | TERT PROMOTER ; ADJUVANT TEMOZOLOMIDE ; MALIGNANT GLIOMAS ; GENETIC PATHWAYS ; TUMORS ; EXPRESSION ; MULTIFORME ; RADIOTHERAPY ; NEUROANATOMY ; CONCOMITANT |
收录类别 | SCI |
语种 | 英语 |
项目资助者 | National 973 Programs(2015CB755500 ; 2011CB707804) |
WOS研究方向 | Oncology ; Neurosciences & Neurology |
WOS类目 | Oncology ; Clinical Neurology |
WOS记录号 | WOS:000377915200010 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/12049 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
作者单位 | 1.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China 2.Capital Med Univ, Beijing Neurosurg Inst, Dept Neuropathol, 6 Tiantanxili, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 4.Capital Med Univ, Beijing Neurosurg Inst, Dept Funct Neuroradiol, Beijing 100050, Peoples R China 5.Capital Med Univ, Beijing Tiantan Hosp, Dept Neuroradiol, Beijing 100050, Peoples R China 6.Beijing Inst Brain Disorders, Ctr Brain Tumor, Beijing 100069, Peoples R China |
推荐引用方式 GB/T 7714 | Fan, Xing,Wang, Yinyan,Liu, Yong,et al. Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas[J]. JOURNAL OF NEURO-ONCOLOGY,2016,128(3):455-462. |
APA | Fan, Xing.,Wang, Yinyan.,Liu, Yong.,Liu, Xing.,Zhang, Chuanbao.,...&Jiang, Tao.(2016).Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas.JOURNAL OF NEURO-ONCOLOGY,128(3),455-462. |
MLA | Fan, Xing,et al."Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas".JOURNAL OF NEURO-ONCOLOGY 128.3(2016):455-462. |
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