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White matter integrity in young smokers: a tract-based spatial statistics study
Yu, Dahua1; Yuan, Kai3; Zhang, Baohua1; Liu, Jixin3; Dong, Minghao3; Jin, Chenwang4; Luo, Lin2; Zhai, Jinquan2; Zhao, Ling5; Zhao, Ying1; Gu, Yu1; Xue, Ting1; Liu, Xin1; Lu, Xiaoqi1; Qin, Wei3; Tian, Jie1,6
2016-05-01
发表期刊ADDICTION BIOLOGY
卷号21期号:3页码:679-687
文章类型Article
摘要Previous diffusion tensor imaging (DTI) studies revealed contradictory effects of smoking on fractional anisotropy (FA). Multiple DTI-derived indices may help to deduce the pathophysiological type of white matter (WM) changes and provide more specific biomarkers of WM neuropathology in the whole brain of young smokers. Twenty-three young smokers and 22 age-, education- and gender-matched healthy non-smoking controls participated in this study. Tract-based spatial statistics was employed to investigate the WM microstructure in young smokers by integrating multiple indices, including FA, mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD). Compared with healthy non-smoking controls, young smokers showed significantly increased FA with increased AD and decreased RD in several brain regions, while no difference in MD was observed. Specifically, the overlapped WM regions with increased FA, increased AD and decreased RD were found in the right posterior limb of the internal capsule, the right external capsule and the right superior corona radiata. Additionally, average FA and RD values in the WM regions mentioned earlier were significantly correlated with pack-years and Fagerstrom Test for Nicotine Dependence, while no correlation in AD was found. The WM tracts with increased FA may be more associated with RD, rather than AD in young smokers. We suggested that WM properties of several fibres in young smokers may be the biomarker as the cumulative effect and severity of nicotine dependence.
关键词Diffusion Tensor Imaging Smoking Tract-based Spatial Statistics
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1111/adb.12237
关键词[WOS]MICROSTRUCTURAL INTEGRITY ; CIGARETTE-SMOKING ; NICOTINE EXPOSURE ; ADOLESCENT BRAIN ; CORPUS-CALLOSUM ; TOBACCO-SMOKE ; DIFFUSION ; CORTEX ; MRI ; ABSTINENCE
收录类别SCI
语种英语
项目资助者Project for the National Key Basic Research and Development Program (973)(2014CB543203 ; National Natural Science Foundation of China(81301281 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ4118) ; Fundamental Research Funds for the Central Universities(8002-72125760 ; Natural Science Foundation of Inner Mongolia(2012MS0908) ; China Post- doctoral Science Foundation(2014M552416) ; Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region ; 2011CB707700 ; 61179019 ; 8002-72135767 ; 2012CB518501) ; 81101036 ; 8002-72145760) ; 81101108 ; 81471737 ; 81473603 ; 81401488 ; 81460279 ; 61261028 ; 81401478 ; 81271644 ; 81271546 ; 81227901 ; 31200837 ; 81030027)
WOS研究方向Biochemistry & Molecular Biology ; Substance Abuse
WOS类目Biochemistry & Molecular Biology ; Substance Abuse
WOS记录号WOS:000374486200013
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/12218
专题中国科学院分子影像重点实验室
通讯作者Yu, Dahua
作者单位1.Inner Mongolia Univ Sci & Technol, Inner Mongolia Key Lab Pattern Recognit & Intelli, Sch Informat Engn, 7 Arden St, Baotou 014010, Inner Mongolia, Peoples R China
2.Inner Mongolia Univ Sci & Technol, Dept Med Imaging, Baotou Med Coll, Affiliated Hosp 1, Baotou 014010, Inner Mongolia, Peoples R China
3.Xidian Univ, Sch Life Sci & Technol, Life Sci Res Ctr, 266 Xinglong Sect Xifeng Rd, Xian 710071, Shaanxi, Peoples R China
4.Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Med Imaging, Xian, Peoples R China
5.Chengdu Univ Tradit Chinese Med, Teaching Hosp 3, Chengdu, Peoples R China
6.Chinese Acad Sci, Inst Automat, Beijing 100864, Peoples R China
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GB/T 7714
Yu, Dahua,Yuan, Kai,Zhang, Baohua,et al. White matter integrity in young smokers: a tract-based spatial statistics study[J]. ADDICTION BIOLOGY,2016,21(3):679-687.
APA Yu, Dahua.,Yuan, Kai.,Zhang, Baohua.,Liu, Jixin.,Dong, Minghao.,...&Tian, Jie.(2016).White matter integrity in young smokers: a tract-based spatial statistics study.ADDICTION BIOLOGY,21(3),679-687.
MLA Yu, Dahua,et al."White matter integrity in young smokers: a tract-based spatial statistics study".ADDICTION BIOLOGY 21.3(2016):679-687.
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