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Theranostic imaging of liver cancer using targeted optical/MRI dual-modal probes
Chen, Qingshan1,2; Shang, Wenting2,3; Zeng, Chaoting1,2; Wang, Kun2,3; Liang, Xiaoyuan2,3; Chi, Chongwei2,3; Liang, Xiao2,3; Yang, Jian1,2; Fang, Chihua1; Tian, Jie2,3
2017-05-16
发表期刊ONCOTARGET
卷号8期号:20页码:32741-32751
文章类型Article
摘要The accurate preoperative detection and intraoperative navigation afforded by imaging techniques have had significant impact on the success of liver cancer surgeries. However, it is difficult to achieve satisfactory performance in both diagnosis and surgical treatment processes using any single modality imaging method. Here, we report the synthesis and characteristics of a novel dual-modality magnetic resonance imaging (MRI) and near-infrared fluorescence (NIRF) probe and verify its feasibility in nude mouse models with liver cancer. The probes are comprised of superparamagnetic iron oxide (SPIO) nanoparticles coated with liposomes to which a tumor-targeted agent, Arg-Gly-Asp peptides (RGD), and a NIRF dye (indocyanine green, ICG) have been conjugated. Specific targeting, biodistribution, and the imaging ability of the probes for MRI-NIRF were examined. Furthermore, we applied the dual-modality methodology toward the preoperative diagnosis and intraoperative guidance of radical resection in mouse models with both orthotopic liver tumors and intrahepatic tumor metastasis. The study demonstrated that both MRI and fluorescent images showed clear tumor delineation after probe injection (SPIO@Liposome-ICG-RGD). The contrast-to-noise ratio obtained from MRI was 31.9 +/- 25.4 at post-injection for the preoperative diagnosis, which is helpful for detecting small tumors (0.9 +/- 0.5 mm). The maximum tumor to background ratio of NIRF imaging was 2.5 +/- 0.3 at 72 h post- injection for effectively capturing miniscule tumor lesions (0.6 +/- 0.3 mm) intraoperatively. The novel MRI- NIRF dual modality probes are promising for the achievement of more accurate liver tumor detection and resection.
关键词Liver Cancer Mri/optical Preoperative Diagnosis Intraoperative Navigation Dual-modality
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.18632/oncotarget.15642
关键词[WOS]MRI CONTRAST AGENTS ; HEPATOCELLULAR-CARCINOMA ; INDOCYANINE GREEN ; NANOPARTICLES ; MAGNETOLIPOSOMES ; FLUORESCENCE ; ANGIOGENESIS ; THERAPY
收录类别SCI
语种英语
项目资助者National Basic Research Program of China (973 Program)(2015CB755500) ; National Natural Science Foundation of China(81227901 ; National High Technology Research and Development Program of China (863 Program)(2012AA021105) ; National Natural Science Foundation of China-Guangdong United Funds(U1401254) ; "Climbing Program" Special Funds: Guangdong province science and technology plan(pdjh2016a0090 ; Digital Theranostic Equipment Research Special program of The "13th five-year" National Key Research Plan(2016YFC0106500) ; Major Instrument Project of National Natural Science Fund(81627805) ; Science and Technology Plan Project of Guangzhou(201604020144) ; 61231004 ; pdjh2016b0103 ; 81501540 ; 2016A020220013) ; 61401462 ; 61501462 ; 81527805 ; 81470083)
WOS研究方向Oncology ; Cell Biology
WOS类目Oncology ; Cell Biology
WOS记录号WOS:000401767700030
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15102
专题中国科学院分子影像重点实验室
作者单位1.Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510280, Guangdong, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
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Chen, Qingshan,Shang, Wenting,Zeng, Chaoting,et al. Theranostic imaging of liver cancer using targeted optical/MRI dual-modal probes[J]. ONCOTARGET,2017,8(20):32741-32751.
APA Chen, Qingshan.,Shang, Wenting.,Zeng, Chaoting.,Wang, Kun.,Liang, Xiaoyuan.,...&Tian, Jie.(2017).Theranostic imaging of liver cancer using targeted optical/MRI dual-modal probes.ONCOTARGET,8(20),32741-32751.
MLA Chen, Qingshan,et al."Theranostic imaging of liver cancer using targeted optical/MRI dual-modal probes".ONCOTARGET 8.20(2017):32741-32751.
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