Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| A tantalum oxide-based core/shell nanoparticle for triple-modality image-guided chemo-thermal synergetic therapy of esophageal carcinoma | |
Jin, Yushen1,2 ; Ma, Xibo1,2; Zhang, Shuai3; Meng, Hui1; Xu, Min1,2; Yang, Xin1,2; Xu, Wanhai5; Tian, Jie1,2,4
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| 发表期刊 | CANCER LETTERS
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| 2017 | |
| 卷号 | 397期号:0页码:61-71 |
| 文章类型 | Article |
| 摘要 | Early detection and therapy of esophageal cancer is very important for improving the prognosis and survival rate of the patient. A theranostic agent that combines multimodal imaging with cancer therapy may be used for augmenting the visualization and treatment of the cancer. Herein, we report the synthesis of a hollow tantalum oxide (TaOx) nanoparticle that was successfully engineered by encapsulation of polypyrrole (PPy) and doxorubicin (DOX) in the core and conjugation with a near infrared fluorescence dye (NIRDye800) on the shell of the hollow TaOx nanoparticles. The as-prepared core/shell nanoparticles showed multimodal imaging features including computed tomography (CT) (for the preliminary location of the tumor), photoacoustic (for the anatomical localization of the tumor), and fluorescence imaging (for real-time monitoring of the tumor margin) and pH- and thermal-sensitive drug release. Because the early esophageal carcinoma is a type of superficial cancer, a subcutaneous model in the thigh was used for the in vivo study. The core/shell nanoparticles shows high imaging contrast between the tumor and the adjacent tissues and controllable photothermal therapy (PTT) and chemotherapy. Our results indicated that the obtained core/shell nanoparticles had significant potential in the triple-modality imaging guided precisely chemo-thermal synergetic therapy of esophageal cancer. In addition, after aerosol administration, our nanoparticles also exhibited comparable therapeutic efficacy with the intravenous administration, which is more suitable for clinical therapy of esophageal carcinoma. (C) 2017 Elsevier B.V. All rights reserved. |
| 关键词 | Tantalum Oxide Triggered Drug Release Chemo-thermal Synergetic Therapy Triple-modality Imaging Esophageal Carcinoma |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| DOI | 10.1016/j.canlet.2017.03.030 |
| 关键词[WOS] | IN-VIVO ; GOLD NANOPARTICLES ; TUMOR-THERAPY ; DRUG-RELEASE ; LIVING MICE ; CANCER ; FLUORESCENCE ; NANOPLATFORM ; TOMOGRAPHY ; ABLATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| 项目资助者 | National Key Research and Development Program of China(2016YFA0201401) ; National Natural Science Foundation of China(81227901 ; National Key Research Program of China(2016YFA0100900) ; Scientific Research and Equipment Development Project of Chinese Academy of Sciences(YZ201457) ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; 81527805 ; 81471739 ; 61231004) |
| WOS研究方向 | Oncology |
| WOS类目 | Oncology |
| WOS记录号 | WOS:000401382000007 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/15105 |
| 专题 | 中国科学院分子影像重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Shandong Univ, Dept Control Sci & Engn, Jinan 250061, Peoples R China 4.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 5.Harbin Med Univ, Dept Urol Surg, Hosp 4, Harbin 150001, Peoples R China |
| 第一作者单位 | 中国科学院分子影像重点实验室 |
| 推荐引用方式 GB/T 7714 | Jin, Yushen,Ma, Xibo,Zhang, Shuai,et al. A tantalum oxide-based core/shell nanoparticle for triple-modality image-guided chemo-thermal synergetic therapy of esophageal carcinoma[J]. CANCER LETTERS,2017,397(0):61-71. |
| APA | Jin, Yushen.,Ma, Xibo.,Zhang, Shuai.,Meng, Hui.,Xu, Min.,...&Tian, Jie.(2017).A tantalum oxide-based core/shell nanoparticle for triple-modality image-guided chemo-thermal synergetic therapy of esophageal carcinoma.CANCER LETTERS,397(0),61-71. |
| MLA | Jin, Yushen,et al."A tantalum oxide-based core/shell nanoparticle for triple-modality image-guided chemo-thermal synergetic therapy of esophageal carcinoma".CANCER LETTERS 397.0(2017):61-71. |
| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
| A tantalum oxide-bas（4716KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 浏览 | |
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