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A tantalum oxide-based core/shell nanoparticle for triple-modality image-guided chemo-thermal synergetic therapy of esophageal carcinoma
Jin, Yushen1,2; Ma, Xibo1,2; Zhang, Shuai3; Meng, Hui1; Xu, Min1,2; Yang, Xin1,2; Xu, Wanhai5; Tian, Jie1,2,4
发表期刊CANCER LETTERS
2017
卷号397期号:0页码:61-71
文章类型Article
摘要Early detection and therapy of esophageal cancer is very important for improving the prognosis and survival rate of the patient. A theranostic agent that combines multimodal imaging with cancer therapy may be used for augmenting the visualization and treatment of the cancer. Herein, we report the synthesis of a hollow tantalum oxide (TaOx) nanoparticle that was successfully engineered by encapsulation of polypyrrole (PPy) and doxorubicin (DOX) in the core and conjugation with a near infrared fluorescence dye (NIRDye800) on the shell of the hollow TaOx nanoparticles. The as-prepared core/shell nanoparticles showed multimodal imaging features including computed tomography (CT) (for the preliminary location of the tumor), photoacoustic (for the anatomical localization of the tumor), and fluorescence imaging (for real-time monitoring of the tumor margin) and pH- and thermal-sensitive drug release. Because the early esophageal carcinoma is a type of superficial cancer, a subcutaneous model in the thigh was used for the in vivo study. The core/shell nanoparticles shows high imaging contrast between the tumor and the adjacent tissues and controllable photothermal therapy (PTT) and chemotherapy. Our results indicated that the obtained core/shell nanoparticles had significant potential in the triple-modality imaging guided precisely chemo-thermal synergetic therapy of esophageal cancer. In addition, after aerosol administration, our nanoparticles also exhibited comparable therapeutic efficacy with the intravenous administration, which is more suitable for clinical therapy of esophageal carcinoma. (C) 2017 Elsevier B.V. All rights reserved.
关键词Tantalum Oxide Triggered Drug Release Chemo-thermal Synergetic Therapy Triple-modality Imaging Esophageal Carcinoma
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.canlet.2017.03.030
关键词[WOS]IN-VIVO ; GOLD NANOPARTICLES ; TUMOR-THERAPY ; DRUG-RELEASE ; LIVING MICE ; CANCER ; FLUORESCENCE ; NANOPLATFORM ; TOMOGRAPHY ; ABLATION
收录类别SCI
语种英语
项目资助者National Key Research and Development Program of China(2016YFA0201401) ; National Natural Science Foundation of China(81227901 ; National Key Research Program of China(2016YFA0100900) ; Scientific Research and Equipment Development Project of Chinese Academy of Sciences(YZ201457) ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; 81527805 ; 81471739 ; 61231004)
WOS研究方向Oncology
WOS类目Oncology
WOS记录号WOS:000401382000007
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/15105
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Shandong Univ, Dept Control Sci & Engn, Jinan 250061, Peoples R China
4.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
5.Harbin Med Univ, Dept Urol Surg, Hosp 4, Harbin 150001, Peoples R China
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GB/T 7714
Jin, Yushen,Ma, Xibo,Zhang, Shuai,et al. A tantalum oxide-based core/shell nanoparticle for triple-modality image-guided chemo-thermal synergetic therapy of esophageal carcinoma[J]. CANCER LETTERS,2017,397(0):61-71.
APA Jin, Yushen.,Ma, Xibo.,Zhang, Shuai.,Meng, Hui.,Xu, Min.,...&Tian, Jie.(2017).A tantalum oxide-based core/shell nanoparticle for triple-modality image-guided chemo-thermal synergetic therapy of esophageal carcinoma.CANCER LETTERS,397(0),61-71.
MLA Jin, Yushen,et al."A tantalum oxide-based core/shell nanoparticle for triple-modality image-guided chemo-thermal synergetic therapy of esophageal carcinoma".CANCER LETTERS 397.0(2017):61-71.
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