Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery

doi:10.1016/j.nano.2017.01.005

	Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery
	Hu, Zhenhua1,2 ; Chi, Chongwei1 ; Liu, Muhan 1; Guo, Hongbo 1; Zhang, Zeyu1 ; Zeng, Chaoting 1; Ye, Jinzuo1 ; Wang, Jing 3; Tian, Jie 1,2; Yang, Weidong 3; Xu, Wanhai 4
发表期刊	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
	2017-05-01
卷号	13 期号:4 页码:1323-1331
文章类型	Article
摘要	Fluorescent molecular imaging technique has been actively explored for optical image-guided cancer surgery in pre-clinical and clinical research and has attracted many attentions. However, the efficacy of the fluorescent image-guided cancer surgery can be compromised by the low signal-to-noise ratio caused by the external light excitation. This study presents a novel nanoparticle-mediated radiopharmaceutical-excited fluorescent (REF) image-guided cancer surgery strategy, which employs the internal dual-excitation of europium oxide nanoparticles through both gamma rays and Cerenkov luminescence emitted from radiopharmaceuticals. The performance of the novel image-guided surgery technique was systematically evaluated using subcutaneous breast cancer 4 T1 tumor models, orthotropic and orthotropic-ectopic hepatocellular carcinoma tumor-bearingmice. The results reveal that the novel REF image-guided cancer surgery technique exhibits high performance of detecting invisible ultra-small size tumor (even less than 1 mm) and residual tumor tissue. Our study demonstrates the high potential of the novel image-guided cancer surgery for precise tumor resection. (C) 2017 Elsevier Inc. All rights reserved.
关键词	Radiopharmaceutical-excited Fluorescence Imaging (Refi) Cerenkov Luminescence Imaging (Cli) Radionuclides Hepatocellular Carcinoma (Hcc) Positron Emitting Tomography (Pet)
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.nano.2017.01.005
关键词[WOS]	CERENKOV LUMINESCENCE ENDOSCOPY ; INDOCYANINE GREEN ; CANCER ; METASTASES ; TOMOGRAPHY ; NAVIGATION ; RESECTION ; F-18-FDG ; BIOPSY ; MODEL
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China(81227901 ; National Key Research and Development Program of China(2016YFC0102600) ; 61622117 ; 81671759 ; 81371594 ; 61302024)
WOS研究方向	Science & Technology - Other Topics ; Research & Experimental Medicine
WOS类目	Nanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS记录号	WOS:000402678800002
引用统计	被引频次：35[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/15116
专题	中国科学院分子影像重点实验室
作者单位	1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China 3.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Peoples R China 4.Harbin Med Univ, Affiliated Hosp 4, Dept Urinary Surg, Harbin 150001, Peoples R China
第一作者单位	中国科学院自动化研究所
推荐引用方式 GB/T 7714	Hu, Zhenhua,Chi, Chongwei,Liu, Muhan,et al. Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2017,13(4):1323-1331.
APA	Hu, Zhenhua.,Chi, Chongwei.,Liu, Muhan.,Guo, Hongbo.,Zhang, Zeyu.,...&Xu, Wanhai.(2017).Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,13(4),1323-1331.
MLA	Hu, Zhenhua,et al."Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 13.4(2017):1323-1331.

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