CASIA OpenIR  > 中国科学院分子影像重点实验室
Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery
Hu, Zhenhua1,2; Chi, Chongwei1; Liu, Muhan1; Guo, Hongbo1; Zhang, Zeyu1; Zeng, Chaoting1; Ye, Jinzuo1; Wang, Jing3; Tian, Jie1,2; Yang, Weidong3; Xu, Wanhai4
Source PublicationNANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
2017-05-01
Volume13Issue:4Pages:1323-1331
SubtypeArticle
AbstractFluorescent molecular imaging technique has been actively explored for optical image-guided cancer surgery in pre-clinical and clinical research and has attracted many attentions. However, the efficacy of the fluorescent image-guided cancer surgery can be compromised by the low signal-to-noise ratio caused by the external light excitation. This study presents a novel nanoparticle-mediated radiopharmaceutical-excited fluorescent (REF) image-guided cancer surgery strategy, which employs the internal dual-excitation of europium oxide nanoparticles through both gamma rays and Cerenkov luminescence emitted from radiopharmaceuticals. The performance of the novel image-guided surgery technique was systematically evaluated using subcutaneous breast cancer 4 T1 tumor models, orthotropic and orthotropic-ectopic hepatocellular carcinoma tumor-bearingmice. The results reveal that the novel REF image-guided cancer surgery technique exhibits high performance of detecting invisible ultra-small size tumor (even less than 1 mm) and residual tumor tissue. Our study demonstrates the high potential of the novel image-guided cancer surgery for precise tumor resection. (C) 2017 Elsevier Inc. All rights reserved.
KeywordRadiopharmaceutical-excited Fluorescence Imaging (Refi) Cerenkov Luminescence Imaging (Cli) Radionuclides Hepatocellular Carcinoma (Hcc) Positron Emitting Tomography (Pet)
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.nano.2017.01.005
WOS KeywordCERENKOV LUMINESCENCE ENDOSCOPY ; INDOCYANINE GREEN ; CANCER ; METASTASES ; TOMOGRAPHY ; NAVIGATION ; RESECTION ; F-18-FDG ; BIOPSY ; MODEL
Indexed BySCI
Language英语
Funding OrganizationNational Natural Science Foundation of China(81227901 ; National Key Research and Development Program of China(2016YFC0102600) ; 61622117 ; 81671759 ; 81371594 ; 61302024)
WOS Research AreaScience & Technology - Other Topics ; Research & Experimental Medicine
WOS SubjectNanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS IDWOS:000402678800002
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/15116
Collection中国科学院分子影像重点实验室
Affiliation1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
3.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Peoples R China
4.Harbin Med Univ, Affiliated Hosp 4, Dept Urinary Surg, Harbin 150001, Peoples R China
Recommended Citation
GB/T 7714
Hu, Zhenhua,Chi, Chongwei,Liu, Muhan,et al. Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2017,13(4):1323-1331.
APA Hu, Zhenhua.,Chi, Chongwei.,Liu, Muhan.,Guo, Hongbo.,Zhang, Zeyu.,...&Xu, Wanhai.(2017).Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,13(4),1323-1331.
MLA Hu, Zhenhua,et al."Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 13.4(2017):1323-1331.
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