Cerenkov luminescence imaging on evaluation of early response to chemotherapy of drug-resistant gastric cancer

doi:10.1016/j.nano.2017.10.001

	Cerenkov luminescence imaging on evaluation of early response to chemotherapy of drug-resistant gastric cancer
	Liu, Muhan 1,2,3,4; Zheng, Sheng 5; Zhang, Xiaojun 6; Guo, Hongbo 3,4,7; Shi, Xiaojing3,4,8 ; Kang, Xiaoyu 9; Qu, Yawei 5; Hu, Zhenhua3,4,8,10 ; Tian, Jie 1,2,3,4,8
发表期刊	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
	2018
卷号	14 期号:1 页码:205-213
文章类型	Article
摘要	Apoptosis imaging enables a timely and specific assessment of treatment response in cancer patients. In this study, we applied a probe for positron emission tomography (PET), which served as an optical biomaterial emitting Cerenkov photons, to in vivo optical imaging of tumor apoptosis, in order to evaluate early response to chemotherapy of drug-resistant gastric cancer. Ga-68-DOTA-Annexin V was prepared as the apoptosis targeting probe. Wild type human gastric adenocarcinoma cell line SGC7901/WT and drug vincristine-resistant variant SGC7901/VCR were used to establish normal and vincristine-resistant xenografts to simulate treatment decision situation. Vincristine-resistance of SGC7901/VCR and apoptosis-induction ability of vincristine and cisplatin were verified. In vitro and in vivo CLI of apoptosis was performed. Stronger signals of apoptosis of CLI correlated with confirmed higher levels of apoptosis and subsequent changes in tumor sizes. Our study suggests that CLI is a promising technique for in vivo imaging of apoptosis with radiopharmaceutical-labeled biomaterials. (C) 2017 Elsevier Inc. All rights reserved.
关键词	Apoptosis Cerenkov Luminescence Imaging Vincristine-resistance Gastric Cancer Cisplatin
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
DOI	10.1016/j.nano.2017.10.001
关键词[WOS]	APOPTOSIS ; TOMOGRAPHY ; EMISSION ; MODEL ; RADIOTRACER ; MICE ; A5
收录类别	SCI
语种	英语
项目资助者	National Natural Science Foundation of China (NSFC)(81227901 ; National Key Research and Development Program of China(2016YFC0102600) ; Strategic Priority Research Program from Chinese Academy of Sciences(XDB02060010) ; International Innovation Team of CAS(20140491524) ; Beijing Municipal Science & Technology Commission(Z161100002616022) ; Scientific Instrument Developing Project of the Chinese Academy of Sciences(YZ201672) ; 81527805 ; 61231004 ; 61622117 ; 81671759 ; 61302024)
WOS研究方向	Science & Technology - Other Topics ; Research & Experimental Medicine
WOS类目	Nanoscience & Nanotechnology ; Medicine, Research & Experimental
WOS记录号	WOS:000423842300020
引用统计	被引频次：30[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/19549
专题	中国科学院分子影像重点实验室
作者单位	1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian, Shaanxi, Peoples R China 2.Xidian Univ, Sch Life Sci & Technol, Xian, Shaanxi, Peoples R China 3.Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China 4.Beijing Key Lab Mol Imaging, Beijing, Peoples R China 5.Chinese Peoples Armed Police Forces, Dept Gastroenterol, Gen Hosp, Beijing, Peoples R China 6.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing, Peoples R China 7.Northwest Univ, Sch Informat Sci & Technol, Xian, Shaanxi, Peoples R China 8.Univ Chinese Acad Sci, Beijing, Peoples R China 9.Fourth Mil Med Univ, Xijing Hosp Digest Dis, State Key Lab Canc Biol, Xian, Shaanxi, Peoples R China 10.State Key Lab Management & Control Complex Syst, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Liu, Muhan,Zheng, Sheng,Zhang, Xiaojun,et al. Cerenkov luminescence imaging on evaluation of early response to chemotherapy of drug-resistant gastric cancer[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2018,14(1):205-213.
APA	Liu, Muhan.,Zheng, Sheng.,Zhang, Xiaojun.,Guo, Hongbo.,Shi, Xiaojing.,...&Tian, Jie.(2018).Cerenkov luminescence imaging on evaluation of early response to chemotherapy of drug-resistant gastric cancer.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,14(1),205-213.
MLA	Liu, Muhan,et al."Cerenkov luminescence imaging on evaluation of early response to chemotherapy of drug-resistant gastric cancer".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 14.1(2018):205-213.

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