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Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia | |
Fang, Xiaojing1; Wang, Yulin2; Cheng, Luqi1; Zhang, Yuanchao1; Zhou, Yuan3,4![]() ![]() | |
发表期刊 | BRAIN IMAGING AND BEHAVIOR
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2018-04-01 | |
卷号 | 12期号:2页码:335-344 |
文章类型 | Article |
摘要 | Working memory (WM) deficit is a core feature of schizophrenia and is characterized by abnormal functional integration in the prefrontal cortex, including the dorsolateral prefrontal cortex (dLPFC), dorsal anterior cingulate cortex (dACC), and ventrolateral prefrontal cortex (vLPFC). However, the specific mechanism by which the abnormal neuronal circuits that involve these brain regions contribute to this deficit is still unclear. Therefore, this study focused on these regions and sought to answer which abnormal causal relationships in these regions can be linked to impaired WM in schizophrenia. We used spectral dynamic causal modeling to estimate directed (effective) connectivity between these regions based on resting-state functional magnetic resonance imaging data from healthy control (HC) subjects and patients with first-episode schizophrenia (FES). By comparing these effective connections in the controls and patients, we found that the effective connectivity from the dACC to the dLPFC and from the right dLPFC to the left vLPFC was weaker in the FES group than in the HC group. Furthermore, these effective connections displayed a positive correlation with WM performance in the HCs. However, in the FES patients, the effective connectivity from the dACC to the dLPFC was not correlated with WM performance, and the effective connectivity from the right dLPFC to the left vLPFC was negatively correlated with WM performance. These results could be explained by an aberrant top-down mechanism of WM processing and provide new evidence for the dysconnectivity hypothesis of schizophrenia. |
关键词 | Resting-state Fmri Effective Connectivity Schizophrenia Spectral Dynamic Causal Modeling Working Memory Deficit |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
DOI | 10.1007/s11682-017-9692-0 |
关键词[WOS] | ALTERED EFFECTIVE CONNECTIVITY ; FUNCTIONAL CONNECTIVITY ; COGNITIVE CONTROL ; SYNAPTIC PLASTICITY ; CORTEX ; FMRI ; NETWORK ; DISCONNECTION ; DYSFUNCTION ; ACTIVATION |
收录类别 | SCI ; SSCI |
语种 | 英语 |
项目资助者 | National Basic Research Program of China(2011CB707800) ; National Natural Science Foundation of China(91132301) ; Youth Innovation Promotion Association of Chinese Academy of Sciences(2012075) ; Plan A of Science and Technology Support Program from Science and Technology Department of Sichuan Province(2014SZ0014) ; Natural Science Foundation of Hubei Province(2014CFB732) |
WOS研究方向 | Neurosciences & Neurology |
WOS类目 | Neuroimaging |
WOS记录号 | WOS:000429029000004 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/20323 |
专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
作者单位 | 1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Sichuan, Peoples R China 2.Vrije Univ Brussel, Fac Psychol & Educ Sci, Dept Expt & Appl Psychol, Res Grp Biol Psychol, Brussels, Belgium 3.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing, Peoples R China 5.Wuhan Univ, Dept Psychiat, Renmin Hosp, Wuhan, Hubei, Peoples R China 6.Wuhan Univ, Dept Radiol, Renmin Hosp, Wuhan, Hubei, Peoples R China 7.Hubei Prov Key Lab Dev Originated Dis, Wuhan, Hubei, Peoples R China 8.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 9.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 10.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci, Beijing, Peoples R China 11.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia |
推荐引用方式 GB/T 7714 | Fang, Xiaojing,Wang, Yulin,Cheng, Luqi,et al. Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia[J]. BRAIN IMAGING AND BEHAVIOR,2018,12(2):335-344. |
APA | Fang, Xiaojing.,Wang, Yulin.,Cheng, Luqi.,Zhang, Yuanchao.,Zhou, Yuan.,...&Jiang, Tianzi.(2018).Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia.BRAIN IMAGING AND BEHAVIOR,12(2),335-344. |
MLA | Fang, Xiaojing,et al."Prefrontal dysconnectivity links to working memory deficit in first-episode schizophrenia".BRAIN IMAGING AND BEHAVIOR 12.2(2018):335-344. |
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